Articles

Multi-tissue and multi-scale approach for nuclei segmentation in H&E stained images

Accurate nuclei detection and segmentation in histological images is essential for many clinical purposes. While manual annotations are time-consuming and operator-dependent, full automated segmentation remain...

Authors: Massimo Salvi and Filippo Molinari

Surface functionalization of TiO₂ nanotubes with minocycline and its in vitro biological effects on Schwann cells

Minocycline has been widely used in central nervous system disease. However, the effect of minocycline on the repairing of nerve fibers around dental implants had not been previously investigated. The aim of t...

Authors: Lan A, Wenzhou Xu, Jinghui Zhao, Chunyan Li, Manlin Qi, Xue Li, Lin Wang and Yanmin Zhou

In vivo degradation and neovascularization of silk fibroin implants monitored by multiple modes ultrasound for surgical applications

In this paper we aimed to investigate the neovascularization and biodegradation of the silk fibroin in vivo using multiple modes ultrasound, including two-dimensional, three-dimensional and contrast-enhanced u...

Authors: Shouqiang Li, Dandan Yu, Huan Ji, Baocun Zhao, Lili Ji and Xiaoping Leng

A new approach to the intracardiac inverse problem using Laplacian distance kernel

The inverse problem in electrophysiology consists of the accurate estimation of the intracardiac electrical sources from a reduced set of electrodes at short distances and from outside the heart. This estimati...

Authors: Raúl Caulier-Cisterna, Sergio Muñoz-Romero, Margarita Sanromán-Junquera, Arcadi García-Alberola and José Luis Rojo-Álvarez

Hemodynamic performance within crossed stent grafts: computational and experimental study on the effect of cross position and angle

The crossed limbs stent graft technique is regularly employed to treat abdominal aortic aneurysm patients with unfavorable aneurysm necks or widely splayed common iliac arteries. This article numerically evalu...

Authors: Ming Liu, Anqiang Sun and Xiaoyan Deng

Estimation of the variations in mechanical impedance between the actuator and the chest, and the power delivered to the chest during cardiopulmonary resuscitation using machine-embedded sensors

To reduce the risk of patient damage and complications during the cardiopulmonary resuscitation (CPR) process in emergency situations, it is necessary to monitor the status of the patient and the quality of CP...

Authors: Seong Wook Choi, Do Yeon Lee and Kyoung Won Nam

Comparison of synthetic aperture architectures for miniaturised ultrasound imaging front-ends

Point of care ultrasonography has been the focus of extensive research over the past few decades. Miniaturised, wireless systems have been envisaged for new application areas, such as capsule endoscopy, implan...

Authors: Graham Peyton, Martyn G. Boutelle and Emmanuel M. Drakakis

A novel TIRADS of US classification

Thyroid imaging reporting and data system (TIRADS) is the assessment of a risk stratification of thyroid nodules, usually using a score. However, there is no consensus as to the version of TIRADS for reporting...

Authors: Yan Zhuang, Cheng Li, Zhan Hua, Ke Chen and Jiang Li Lin

Novel blood pressure and pulse pressure estimation based on pulse transit time and stroke volume approximation

Non-invasive continuous blood pressure monitors are of great interest to the medical community due to their value in hypertension management. Recently, studies have shown the potential of pulse pressure as a ...

Authors: Joonnyong Lee, JangJay Sohn, Jonghyun Park, SeungMan Yang, Saram Lee and Hee Chan Kim

Numerical study of gene electrotransfer efficiency based on electroporation volume and electrophoretic movement of plasmid DNA

The efficiency of gene electrotransfer, an electroporation-based method for delivery of pDNA into target tissues, depends on several processes. The method relies on application of electric pulses with appropri...

Authors: Tadeja Forjanič and Damijan Miklavčič

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments...

Authors: Da Un Jeong and Ki Moo Lim

Semiautomatic intermittent pneumatic compression device applied to deep vein thrombosis in major orthopedic surgery

To investigate the effect of additional semiautomatic intermittent pneumatic compression device (IPCD) in the prevention of deep vein thrombosis (DVT) of lower extremity in these patients undergoing major orth...

Authors: Dapeng Wang, Fuqin Bao, Qiang Li, Yugang Teng and Jianjun Li

Combining SENSE and reduced field-of-view for high-resolution diffusion weighted magnetic resonance imaging

In diffusion-weighted magnetic resonance imaging (DWI) using single-shot echo planar imaging (ss-EPI), both reduced field-of-view (FOV) excitation and sensitivity encoding (SENSE) alone can increase in-plane r...

Authors: Jisu Hu, Ming Li, Yakang Dai, Chen Geng, Baotong Tong, Zhiyong Zhou, Xue Liang, Wen Yang and Bing Zhang

Blind blur assessment of MRI images using parallel multiscale difference of Gaussian filters

Rician noise, bias fields and blur are the common distortions that degrade MRI images during acquisition. Blur is unique in comparison to Rician noise and bias fields because it can be introduced into an image...

Authors: Michael E. Osadebey, Marius Pedersen, Douglas L. Arnold and Katrina E. Wendel-Mitoraj

Noninvasive assessment of age-related stiffness of crystalline lenses in a rabbit model using ultrasound elastography

The pathological or physiological changes of a crystalline lens directly affect the eye accommodation and transmittance, and then they increase the risk of presbyopia and cataracts for people in the middle and...

Authors: Xinyu Zhang, Qingmin Wang, Zhen Lyu, Xuehua Gao, Pengpeng Zhang, Haoming Lin, Yanrong Guo, Tianfu Wang, Siping Chen and Xin Chen

Automatic hand phantom map generation and detection using decomposition support vector machines

There is a need for providing sensory feedback for myoelectric prosthesis users. Providing tactile feedback can improve object manipulation abilities, enhance the perceptual embodiment of myoelectric prosthese...

Authors: Huaiqi Huang, Claudio Bruschini, Christian Antfolk, Christian Enz, Tao Li, Jörn Justiz and Volker M. Koch

GPU based parallel acceleration for fast C-arm cone-beam CT reconstruction

With the introduction of Flat Panel Detector technology, cone-beam CT (CBCT) has become a novel image modality, and widely applied in clinical practices. C-arm mounted CBCT has shown extra suitability in image...

Authors: Ken Chen, Cheng Wang, Jing Xiong and Yaoqin Xie

Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

Air ions are molecules of air that have become ionized—that is, they have either lost or gained an electrical charge. Past speculation has suggested that exposure to positive air ions may be harmful to one’s h...

Authors: William H. Bailey, Amy Lavin Williams and Megan Jeanne Leonhard

Electrical exposure analysis of galvanic-coupled intra-body communication based on the empirical arm models

Intra-body communication (IBC) is one of the highlights in studies of body area networks. The existing IBC studies mainly focus on human channel characteristics of the physical layer, transceiver design for th...

Authors: Yue-Ming Gao, Heng-fei Zhang, Shi Lin, Rui-Xin Jiang, Zhi-Ying Chen, Željka Lučev Vasić, Mang-I Vai, Min Du, Mario Cifrek and Sio-Hang Pun

A pilot study of short T2* measurements with ultrashort echo time imaging at 0.35 T

Ultrashort echo time (UTE) sequences play a key role in imaging and quantifying short T2 species. However, almost all of the relevant studies was conducted at relatively high fields. The purpose of this work w...

Authors: Xiuyuan Chen and Bensheng Qiu

Dysphagia and its effects on swallowing sounds and vibrations in adults

To utilize cervical auscultation as a means of screening for risk of dysphagia, we must first determine how the signal differs between healthy subjects and subjects with swallowing disorders.

Authors: Joshua M. Dudik, Atsuko Kurosu, James L. Coyle and Ervin Sejdić

Computer-aided analysis of micro-morphological structure of porous membranes

The paper presents an approach and computer-aided method of numerical evaluation of the quality of porous membranes used as scaffolds for cultivation of chondrocytes in regeneration of biological tissues.

Authors: Juliusz L. Kulikowski, Malgorzata Przytulska and Andrzej Chwojnowski

Numerical analysis of the pressure drop across highly-eccentric coronary stenoses: application to the calculation of the fractional flow reserve

Fractional flow reverse (FFR) is the gold standard assessment of the hemodynamic significance of coronary stenoses. However, it requires the catheterization of the coronary artery to determine the pressure wav...

Authors: R. Agujetas, M. R. González-Fernández, J. M. Nogales-Asensio and J. M. Montanero

The effect of inlet and outlet boundary conditions in image-based CFD modeling of aortic flow

Computational modeling of cardiovascular flow is a growing and useful field, but such simulations usually require the researcher to guess the flow’s inlet and outlet conditions since they are difficult and exp...

Authors: Sudharsan Madhavan and Erica M. Cherry Kemmerling

Automatic liver segmentation in computed tomography using general-purpose shape modeling methods

Liver segmentation in computed tomography is required in many clinical applications. The segmentation methods used can be classified according to a number of criteria. One important criterion for method select...

Authors: Dominik Spinczyk and Agata Krasoń

Augmented reality-based electrode guidance system for reliable electroencephalography

In longitudinal electroencephalography (EEG) studies, repeatable electrode positioning is essential for reliable EEG assessment. Conventional methods use anatomical landmarks as fiducial locations for the elec...

Authors: Chanho Song, Sangseo Jeon, Seongpung Lee, Ho-Gun Ha, Jonghyun Kim and Jaesung Hong

Automated chest screening based on a hybrid model of transfer learning and convolutional sparse denoising autoencoder

In this paper, we aim to investigate the effect of computer-aided triage system, which is implemented for the health checkup of lung lesions involving tens of thousands of chest X-rays (CXRs) that are required...

Authors: Changmiao Wang, Ahmed Elazab, Fucang Jia, Jianhuang Wu and Qingmao Hu

The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study

Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of...

Authors: Jun I. K. Park, Aulia Khamas Heikhmakhtiar, Chang Hyun Kim, Yoo Seok Kim, Seong Wook Choi, Kwang Soup Song and Ki Moo Lim

Peripheral vascular disease assessment in the lower limb: a review of current and emerging non-invasive diagnostic methods

Worldwide, at least 200 million people are affected by peripheral vascular diseases (PVDs), including peripheral arterial disease (PAD), chronic venous insufficiency (CVI) and deep vein thrombosis (DVT). The h...

Authors: Elham Shabani Varaki, Gaetano D. Gargiulo, Stefania Penkala and Paul P. Breen

Blood hyperviscosity identification with reflective spectroscopy of tongue tip based on principal component analysis combining artificial neural network

With spectral methods, noninvasive determination of blood hyperviscosity in vivo is very potential and meaningful in clinical diagnosis. In this study, 67 male subjects (41 health, and 26 hyperviscosity accord...

Authors: Ming Liu, Jing Zhao, XiaoZuo Lu, Gang Li, Taixia Wu and LiFu Zhang

Hemodynamic effects of perfusion level of peripheral ECMO on cardiovascular system

Peripheral ECMO is an effective cardiopulmonary support in clinical. The perfusion level could directly influence the performances and complications. However, there are few studies on the effects of the perfus...

Authors: Kaiyun Gu, Zhe Zhang, Bin Gao, Yu Chang and Feng Wan

Estimation of spatio-temporal parameters of gait from magneto-inertial measurement units: multicenter validation among Parkinson, mildly cognitively impaired and healthy older adults

The use of miniaturized magneto-inertial measurement units (MIMUs) allows for an objective evaluation of gait and a quantitative assessment of clinical outcomes. Spatial and temporal parameters are generally r...

Authors: Matilde Bertoli, Andrea Cereatti, Diana Trojaniello, Laura Avanzino, Elisa Pelosin, Silvia Del Din, Lynn Rochester, Pieter Ginis, Esther M. J. Bekkers, Anat Mirelman, Jeffrey M. Hausdorff and Ugo Della Croce

The roles of mid-myocardial and epicardial cells in T-wave alternans development: a simulation study

The occurrence of T-wave alternans in electrocardiographic signals was recently linked to susceptibility to ventricular arrhythmias and sudden cardiac death. Thus, by detecting and comprehending the origins of...

Authors: D. Janusek, J. Svehlikova, J. Zelinka, W. Weigl, R. Zaczek, G. Opolski, M. Tysler and R. Maniewski

Mobile GPU-based implementation of automatic analysis method for long-term ECG

Long-term electrocardiogram (ECG) is one of the important diagnostic assistant approaches in capturing intermittent cardiac arrhythmias. Combination of miniaturized wearable holters and healthcare platforms en...

Authors: Xiaomao Fan, Qihang Yao, Ye Li, Runge Chen and Yunpeng Cai

Anti-deception: reliable EEG-based biometrics with real-time capability from the neural response of face rapid serial visual presentation

The electroencephalogram (EEG) signal represents a subject’s specific brain activity patterns and is considered as an ideal biometric given its superior invisibility, non-clonality, and non-coercion. In order ...

Authors: Qunjian Wu, Bin Yan, Ying Zeng, Chi Zhang and Li Tong

A new approach for analysis of heart rate variability and QT variability in long-term ECG recording

With the emergence of long-term electrocardiogram (ECG) recordings that extend several days beyond the typical 24–48 h, the development of new tools to measure heart rate variability (HRV) and QT variability i...

Authors: Hau-Tieng Wu and Elsayed Z. Soliman

Clinical validation and assessment of aortic hemodynamics using computational fluid dynamics simulations from computed tomography angiography

Hemodynamic information including peak systolic pressure (PSP) and peak systolic velocity (PSV) carry an important role in evaluation and diagnosis of congenital heart disease (CHD). Since MDCTA cannot evaluat...

Authors: Yulei Zhu, Rui Chen, Yu-Hsiang Juan, He Li, Jingjing Wang, Zhuliang Yu and Hui Liu

Simulation as a preoperative planning approach in advanced heart failure patients. A retrospective clinical analysis

Modelling and simulation may become clinically applicable tools for detailed evaluation of the cardiovascular system and clinical decision-making to guide therapeutic intervention. Models based on pressure–vol...

Authors: Massimo Capoccia, Silvia Marconi, Sanjeet Avtaar Singh, Domenico M. Pisanelli and Claudio De Lazzari

Proprioceptive impairments in high fall risk older adults: the effect of mechanical calf vibration on postural balance

Impairments in proprioceptive mechanism with aging has been observed and associated with fall risk. The purpose of the current study was to assess proprioceptive deficits among high fall risk individuals in co...

Authors: Nima Toosizadeh, Hossein Ehsani, Marco Miramonte and Jane Mohler

The primary stability of different implants for intra-articular calcaneal fractures: an in vitro study

Calcaneal fractures account for around 2% of all fractures and most of them are intra-articular fractures. Many implants have been used in the fixation of calcaneal fractures, but their biomechanical stability...

Authors: Ming Ni, Jiong Mei, Kun Li, Wenxin Niu and Ming Zhang

Localized instance fusion of MRI data of Alzheimer’s disease for classification based on instance transfer ensemble learning

Diagnosis of Alzheimer’s disease (AD) is very important, and MRI is an effective imaging mode of Alzheimer’s disease. There are many existing studies on the diagnosis of Alzheimer’s disease based on MRI data. ...

Authors: Xiaoheng Tan, Yuchuan Liu, Yongming Li, Pin Wang, Xiaoping Zeng, Fang Yan and Xinke Li

Relationship between movement time and hip moment impulse in the sagittal plane during sit-to-stand movement: a combined experimental and computer simulation study

The association between repetitive hip moment impulse and the progression of hip osteoarthritis is a recently recognized area of study. A sit-to-stand movement is essential for daily life and requires hip exte...

Authors: Takuma Inai, Tomoya Takabayashi, Mutsuaki Edama and Masayoshi Kubo

Biomechanical analysis of plate systems for proximal humerus fractures: a systematic literature review

Proximal humerus fractures are the third most common in the human body but their management remains controversial. Open reduction and internal fixation with plates is one of the leading modes of operative trea...

Authors: Ali Jabran, Chris Peach and Lei Ren

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in...

Authors: Chong Ning, Hui-Min David Wang, Rong Gao, Yu-Chia Chang, Fengqing Hu, Xianjun Meng and Shi-Ying Huang

Gamma rays excited radioluminescence tomographic imaging

Radionuclide-excited luminescence imaging is an optical radionuclide imaging strategy to reveal the distributions of radioluminescent nanophosphors (RLNPs) inside small animals, which uses radioluminescence em...

Authors: Xuanxuan Zhang, Shouping Zhu, Yang Li, Yonghua Zhan, Xueli Chen, Fei Kang, Jing Wang and Xu Cao

Dynamic characteristics of oxygen consumption

Authors: Lin Ye, Ahmadreza Argha, Hairong Yu, Branko G. Celler, Hung T. Nguyen and Steven Su

Should fluid dynamics be included in computer models of RF cardiac ablation by irrigated-tip electrodes?

Although accurate modeling of the thermal performance of irrigated-tip electrodes in radiofrequency cardiac ablation requires the solution of a triple coupled problem involving simultaneous electrical conducti...

Authors: Ana González-Suárez, Juan J. Pérez and Enrique Berjano

An extended OpenSim knee model for analysis of strains of connective tissues

OpenSim musculoskeletal models provide an accurate simulation environment that eases limitations of in vivo and in vitro studies. In this work, a biomechanical knee model was formulated with femoral articular ...

Authors: M. Marieswaran, Arnab Sikidar, Anu Goel, Deepak Joshi and Dinesh Kalyanasundaram

Simulation of phase contrast angiography for renal arterial models

With the development of versatile magnetic resonance acquisition techniques there arises a need for more advanced imaging simulation tools to enable adequate image appearance prediction, measurement sequence d...

Authors: Artur Klepaczko, Piotr Szczypiński, Michał Strzelecki and Ludomir Stefańczyk

Technologies to monitor the health of loaded skin tissues

There are many situations where the skin and underlying soft tissues are compromised by mechanical loading in the form or pressure, or pressure in combination with shear. If sustained, this can lead to damage ...

Authors: Dan L. Bader and Peter R. Worsley