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  1. Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood....

    Authors: Hongyun Liu, Ping Zhan, Fangang Meng and Weidong Wang

    Citation: BioMedical Engineering OnLine 2020 19:40

    Content type: Research

    Published on:

  2. Radiotherapy treatment planning dose prediction can be used to ensure plan quality and guide automatic plan. One of the dose prediction methods is incorporating historical treatment planning data into algorith...

    Authors: Xue Bai, Binbing Wang, Shengye Wang, Zhangwen Wu, Chengjun Gou and Qing Hou

    Citation: BioMedical Engineering OnLine 2020 19:39

    Content type: Research

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  3. As the rupture of cerebral aneurysm may lead to fatal results, early detection of unruptured aneurysms may save lives. At present, the contrast-unenhanced time-of-flight magnetic resonance angiography is one o...

    Authors: Geng Chen, Xia Wei, Huang Lei, Yang Liqin, Li Yuxin, Dai Yakang and Geng Daoying

    Citation: BioMedical Engineering OnLine 2020 19:38

    Content type: Research

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  4. Vessel diseases are often accompanied by abnormalities related to vascular shape and size. Therefore, a clear visualization of vasculature is of high clinical significance. Ultrasound color flow imaging (CFI) ...

    Authors: Naiyuan Zhang, Md Ashikuzzaman and Hassan Rivaz

    Citation: BioMedical Engineering OnLine 2020 19:37

    Content type: Review

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  5. Pharyngeal fricative is one typical compensatory articulation error of cleft palate speech. It passively influences daily communication for people who suffer from it. The automatic detection of pharyngeal fric...

    Authors: Fei He, Xiyue Wang, Heng Yin, Han Zhang, Gang Yang and Ling He

    Citation: BioMedical Engineering OnLine 2020 19:36

    Content type: Research

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  6. Electrical conductivity of a biological tissue at low frequencies can be approximately expressed as a tensor. Noting that cross-sectional imaging of a low-frequency conductivity tensor distribution inside the ...

    Authors: Bup Kyung Choi, Nitish Katoch, Hyung Joong Kim, Ji Ae Park, In Ok Ko, Oh In Kwon and Eung Je Woo

    Citation: BioMedical Engineering OnLine 2020 19:35

    Content type: Research

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  7. Functional electrical stimulation is a technique to produce functional movements after paralysis. Electrical discharges are applied to a person’s muscles making them contract in a sequence that allows performi...

    Authors: Cesar Marquez-Chin and Milos R. Popovic

    Citation: BioMedical Engineering OnLine 2020 19:34

    Content type: Review

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  8. In the past years, robotic systems have become increasingly popular in upper limb rehabilitation. Nevertheless, clinical studies have so far not been able to confirm superior efficacy of robotic therapy over c...

    Authors: Christian Giang, Elvira Pirondini, Nawal Kinany, Camilla Pierella, Alessandro Panarese, Martina Coscia, Jenifer Miehlbradt, Cécile Magnin, Pierre Nicolo, Adrian Guggisberg and Silvestro Micera

    Citation: BioMedical Engineering OnLine 2020 19:33

    Content type: Research

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  9. Lung mechanics measurements provide clinically useful information about disease progression and lung health. Currently, there are no commonly practiced methods to non-invasively measure both resistive and elas...

    Authors: Sarah L. Howe, Melanie März, Sabine Krüger-Ziolek, Bernhard Laufer, Chris Pretty, Geoffery M. Shaw, Thomas Desaive, Knut Möller and J. Geoffrey Chase

    Citation: BioMedical Engineering OnLine 2020 19:32

    Content type: Research

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  10. Coarctation of the aorta is a common form of critical congenital heart disease that remains challenging to diagnose prior to clinical deterioration. Despite current screening methods, infants with coarctation ...

    Authors: Matthew W. Sorensen, Ismail Sadiq, Gari D. Clifford, Kevin O. Maher and Matthew E. Oster

    Citation: BioMedical Engineering OnLine 2020 19:31

    Content type: Research

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  11. With the development of wearable health-monitoring technologies, a variety of textile electrodes have been produced and applied by researchers. However, there are no universal and effective methods even testin...

    Authors: Jinzhong Song, Yu Zhang, Yijing Yang, Hao Liu, Tianshu Zhou, Kui Zhang, Fan Li, Zhi Xu, Qingjun Liu and Jingsong Li

    Citation: BioMedical Engineering OnLine 2020 19:30

    Content type: Research

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  12. Balance training improves postural control in Parkinson’s disease (PD). However, a systematic approach for the development of individualized, optimal training programs is still lacking, as the learning dynamic...

    Authors: Zahra Rahmati, Saeed Behzadipour, Alfred C. Schouten, Ghorban Taghizadeh and Keikhosrow Firoozbakhsh

    Citation: BioMedical Engineering OnLine 2020 19:29

    Content type: Research

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  13. Our group developed a rehabilitation robot to assist with repetitive, active reaching movement of a paretic upper extremity. The robot is equipped with a servo motor-controlled arm-weight support and works in ...

    Authors: Yumeko Amano, Tomokazu Noma, Seiji Etoh, Ryuji Miyata, Kentaro Kawamura and Megumi Shimodozono

    Citation: BioMedical Engineering OnLine 2020 19:28

    Content type: Research

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  14. Catheter ablation therapy involving isolation of pulmonary veins (PVs) from the left atrium is performed to terminate atrial fibrillation (AF). Unfortunately, standalone PV isolation procedure has shown to be ...

    Authors: Prasanth Ganesan, Elizabeth M. Cherry, David T. Huang, Arkady M. Pertsov and Behnaz Ghoraani

    Citation: BioMedical Engineering OnLine 2020 19:27

    Content type: Research

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  15. STAR is a model-based, personalised, risk-based dosing approach for glycaemic control (GC) in critically ill patients. STAR provides safe, effective control to nearly all patients, using 1–3 hourly measurement...

    Authors: Vincent Uyttendaele, Jennifer L. Knopp, Geoffrey M. Shaw, Thomas Desaive and J. Geoffrey Chase

    Citation: BioMedical Engineering OnLine 2020 19:26

    Content type: Research

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  16. Emerging sensing and communication technologies are contributing to the development of many motor rehabilitation programs outside the standard healthcare facilities. Nowadays, motor rehabilitation exercises ca...

    Authors: Bojan Milosevic, Alberto Leardini and Elisabetta Farella

    Citation: BioMedical Engineering OnLine 2020 19:25

    Content type: Research

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  17. Trigger finger is a common hand disease, which is caused by a mismatch in diameter between the tendon and the pulley. Ultrasound images are typically used to diagnose this disease, which are also used to guide...

    Authors: Chan-Pang Kuok, Tai-Hua Yang, Bo-Siang Tsai, I-Ming Jou, Ming-Huwi Horng, Fong-Chin Su and Yung-Nien Sun

    Citation: BioMedical Engineering OnLine 2020 19:24

    Content type: Research

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  18. Temporomandibular disorders (TMDs) are pathological conditions affecting the temporomandibular joint and/or masticatory muscles. The current diagnosis of TMDs is complex and multi-factorial, including question...

    Authors: Bruno Coelho Calil, Danilo Vieira da Cunha, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Daniel Antônio Furtado, Douglas Peres Bellomo Junior and Adriano Alves Pereira

    Citation: BioMedical Engineering OnLine 2020 19:22

    Content type: Research

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  19. As one of the major complications of diabetes, diabetic retinopathy (DR) is a leading cause of visual impairment and blindness due to delayed diagnosis and intervention. Microaneurysms appear as the earliest s...

    Authors: Shengchun Long, Jiali Chen, Ante Hu, Haipeng Liu, Zhiqing Chen and Dingchang Zheng

    Citation: BioMedical Engineering OnLine 2020 19:21

    Content type: Research

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  20. This is a systematic review on the main algorithms using machine learning (ML) in retinal image processing for glaucoma diagnosis and detection. ML has proven to be a significant tool for the development of co...

    Authors: Daniele M. S. Barros, Julio C. C. Moura, Cefas R. Freire, Alexandre C. Taleb, Ricardo A. M. Valentim and Philippi S. G. Morais

    Citation: BioMedical Engineering OnLine 2020 19:20

    Content type: Review

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  21. The His–Purkinje (HP) system provides a pathway for the time-synchronous contraction of the heart. His bundle (HB) of the HP system is gaining relevance as a pacing site for treating non-reversible bradyarrhyt...

    Authors: Ankur R. Shah, Muhammad S. Khan, Annie M. Hirahara, Matthias Lange, Ravi Ranjan and Derek J. Dosdall

    Citation: BioMedical Engineering OnLine 2020 19:19

    Content type: Research

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  22. The remineralization approach mechanically occludes the exposed dentinal tubules mechanically, reduces the permeability of dentinal tubules and eliminates the symptoms of dentin hypersensitivity. The aim of th...

    Authors: Zhou Zhou, Xingyun Ge, Minxia Bian, Tao Xu, Na Li, Jiamin Lu and Jinhua Yu

    Citation: BioMedical Engineering OnLine 2020 19:18

    Content type: Research

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  23. Distraction osteogenesis (DO) is an emerging method for bone tissue reconstruction. In oral and maxillofacial reconstruction applications, DO is playing an important role as a technique without the need of bon...

    Authors: Shahrokh Hatefi, Katayoun Hatefi, Francis Le Roux, Javad Alizargar, Zeinolabedin Behdadipour, Yimesker Yihun and Khaled Abou-El-Hossein

    Citation: BioMedical Engineering OnLine 2020 19:17

    Content type: Review

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  24. It was highlighted that the original article [1] contained an error in the Quantitative evaluation of Methods. A bracket was misplaced in the formula. This Correction article shows the incorrect and correct fo...

    Authors: Cuixia Feng, Hulin Zhao, Maoyu Tian, Miaomiao Lu and Junhai Wen

    Citation: BioMedical Engineering OnLine 2020 19:16

    Content type: Correction

    Published on:

    The original article was published in BioMedical Engineering OnLine 2020 19:13

  25. Previous in vitro studies demonstrated that suppression of microRNAs might protect cardiomyocytes and neurons against oxygen–glucose deprivation and reoxygenation (OGD/R)-induced cell apoptosis. However, wheth...

    Authors: Wei Hou, Xianting Zhu, Juan Liu and Jiaguo Map

    Citation: BioMedical Engineering OnLine 2020 19:15

    Content type: Research

    Published on:

  26. Reach–grasp movements are motor components commonly affected after stroke and directly related to the independence of these individuals. Evaluations of these activities can be performed using clinical instrume...

    Authors: Camila L. A. Gomes, Roberta O. Cacho, Viviane T. B. Nobrega, Ellen Marjorie de A. Confessor, Eyshila Emanuelle M. de Farias, José Leôncio F. Neto, Denise S. de Araújo, Ana Loyse de S. Medeiros, Rodrigo L. Barreto and Enio W. A. Cacho

    Citation: BioMedical Engineering OnLine 2020 19:14

    Content type: Research

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  27. Focal cortical dysplasia (FCD) is a neuronal migration disorder and is a major cause of drug-resistant epilepsy. However, many focal abnormalities remain undetected during routine visual inspection, and many p...

    Authors: Cuixia Feng, Hulin Zhao, Maoyu Tian, Miaomiao Lu and Junhai Wen

    Citation: BioMedical Engineering OnLine 2020 19:13

    Content type: Research

    Published on:

    The Correction to this article has been published in BioMedical Engineering OnLine 2020 19:16

  28. Bone defects are often combined with the risk of infection in the clinic, and artificial bone substitutes are often implanted to repair the defective bone. However, the implant materials are carriers for bacte...

    Authors: Rui Ma, Wei Wang, Pei Yang, Chunsheng Wang, Dagang Guo and Kunzheng Wang

    Citation: BioMedical Engineering OnLine 2020 19:12

    Content type: Research

    Published on:

  29. Randomized Controlled Trials (RCTs) are the best method to determine causal effects for treatments if they are well done and well reported. Good evidence about proposed treatments for obesity is needed, and Hs...

    Authors: Luis M. Mestre, Stephanie L. Dickinson, Lilian Golzarri-Arroyo, Andrew W. Brown and David B. Allison

    Citation: BioMedical Engineering OnLine 2020 19:11

    Content type: Letter to the Editor

    Published on:

  30. Epilepsy is one of the most common neurological disorders associated with disruption of brain activity. In the classification and detection of epileptic seizures, electroencephalography (EEG) measurements, whi...

    Authors: Ozlem Karabiber Cura, Sibel Kocaaslan Atli, Hatice Sabiha Türe and Aydin Akan

    Citation: BioMedical Engineering OnLine 2020 19:10

    Content type: Research

    Published on:

  31. The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering,...

    Authors: Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen and Xiuqing Gong

    Citation: BioMedical Engineering OnLine 2020 19:9

    Content type: Review

    Published on:

  32. Uniaxial/biaxial tensile stress has been employed to induce chondrocyte differentiation of mesenchymal stem cells. However, the effects of radial tensile stimuli on differentiation of MSCs into fibrocartilage ...

    Authors: Xuelian Su, Jizeng Wang, Hong Kang, Guangjie Bao and Lin Liu

    Citation: BioMedical Engineering OnLine 2020 19:8

    Content type: Research

    Published on:

  33. Cochlear implants (CIs) have become important for the treatment of severe-to-profound sensorineural hearing loss (SNHL). Meanwhile, electrically evoked compound action potentials (ECAPs) and electrically evoke...

    Authors: Tianhao Lu, Qiang Li, Chen Zhang, Min Chen, Zhengming Wang and Shufeng Li

    Citation: BioMedical Engineering OnLine 2020 19:7

    Content type: Research

    Published on:

  34. The Editors-in-Chief have retracted this article [1] because, after publication, concerns were raised regarding the study design and statistical analysis. Post-publication review has confirmed firstly that wit...

    Authors: Ching-Hsiu Hsieh, Chi-Chuan Tseng, Ju-Yu Shen and Pei-Ying Chuang

    Citation: BioMedical Engineering OnLine 2020 19:6

    Content type: Retraction Note

    Published on:

    The original article was published in BioMedical Engineering OnLine 2018 17:149

  35. Non-invasive discrimination between lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) subtypes of non-small-cell lung cancer (NSCLC) could be very beneficial to the patients unfit for the inva...

    Authors: Xing Tang, Xiaopan Xu, Zhiping Han, Guoyan Bai, Hong Wang, Yang Liu, Peng Du, Zhengrong Liang, Jian Zhang, Hongbing Lu and Hong Yin

    Citation: BioMedical Engineering OnLine 2020 19:5

    Content type: Research

    Published on:

  36. Site-specific variations are challenges for pooling analyses in multi-center studies. This work aims to propose an inter-site harmonization method based on dual generative adversarial networks (GANs) for diffu...

    Authors: Jie Zhong, Ying Wang, Jie Li, Xuetong Xue, Simin Liu, Miaomiao Wang, Xinbo Gao, Quan Wang, Jian Yang and Xianjun Li

    Citation: BioMedical Engineering OnLine 2020 19:4

    Content type: Research

    Published on:

  37. A lack of communication with people suffering from acquired brain injuries may lead to drawing erroneous conclusions regarding the diagnosis or therapy of patients. Information technology and neuroscience make...

    Authors: Andrzej Czyżewski, Adam Kurowski, Piotr Odya and Piotr Szczuko

    Citation: BioMedical Engineering OnLine 2020 19:2

    Content type: Research

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  38. The traditional navigation interface was intended only for two-dimensional observation by doctors; thus, this interface does not display the total spatial information for the lesion area. Surgical navigation s...

    Authors: Long Chen, Fengfeng Zhang, Wei Zhan, Minfeng Gan and Lining Sun

    Citation: BioMedical Engineering OnLine 2020 19:1

    Content type: Research

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  39. Hypertension increases the risk of angiocardiopathy and cognitive disorder. Blood pressure has four categories: normal, elevated, hypertension stage 1 and hypertension stage 2. The quantitative analysis of hyp...

    Authors: Xinying Yu, Bo Peng, Zeyu Xue, Hamidreza Saligheh Rad, Zhenlin Cai, Jun Shi, Jianbing Zhu and Yakang Dai

    Citation: BioMedical Engineering OnLine 2019 18:124

    Content type: Research

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  40. Bone is a hierarchically structured composite material, and different hierarchical levels exhibit diverse material properties and functions. The stress and strain distribution and fluid flow in bone play an im...

    Authors: WeiLun Yu, XiaoGang Wu, HaiPeng Cen, Yuan Guo, ChaoXin Li, YanQin Wang, YiXian Qin and WeiYi Chen

    Citation: BioMedical Engineering OnLine 2019 18:122

    Content type: Research

    Published on:

  41. An efficient and accurate approach to quantify the steatosis extent of liver is important for clinical practice. For the purpose, we propose a specific designed ultrasound shear wave sequence to estimate ultra...

    Authors: Xiudong Shi, Wen Ye, Fengjun Liu, Rengyin Zhang, Qinguo Hou, Chunzi Shi, Jinhua Yu and Yuxin Shi

    Citation: BioMedical Engineering OnLine 2019 18:121

    Content type: Research

    Published on:

  42. Infertility and subfertility affect a significant proportion of humanity. Assisted reproductive technology has been proven capable of alleviating infertility issues. In vitro fertilisation is one such option w...

    Authors: Vidas Raudonis, Agne Paulauskaite-Taraseviciene, Kristina Sutiene and Domas Jonaitis

    Citation: BioMedical Engineering OnLine 2019 18:120

    Content type: Research

    Published on:

  43. Bone scaffold is one of the most effective methods to treat bone defect. The ideal scaffold of bone tissue should not only provide space for bone tissue growth, but also have sufficient mechanical strength to ...

    Authors: Su Wang, Linlin Liu, Xin Zhou, Danfeng Yang, Zhang’ao Shi and Yongqiang Hao

    Citation: BioMedical Engineering OnLine 2019 18:119

    Content type: Research

    Published on:

  44. The objective of this study was to develop a strategy to optimize medical health surveillance protocols for administrative employees using video display terminals (VDTs). A total of 2453 medical examinations w...

    Authors: Saki Gerassis, Alberto Abad, Javier Taboada, Ángeles Saavedra and Eduardo Giráldez

    Citation: BioMedical Engineering OnLine 2019 18:118

    Content type: Research

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  45. One of the major concerns in implantable optoelectronics is the heat generated by emitters such as light emitting diodes (LEDs). Such devices typically produce more heat than light, whereas medical regulations...

    Authors: Fahimeh Dehkhoda, Ahmed Soltan, Nikhil Ponon, Anthony O’Neill, Andrew Jackson and Patrick Degenaar

    Citation: BioMedical Engineering OnLine 2019 18:117

    Content type: Research

    Published on:

  46. This paper investigates the benefits of data filtering via complex dual wavelet transform for metal artifact reduction (MAR). The advantage of using complex dual wavelet basis for MAR was studied on simulated ...

    Authors: Defne Us, Ulla Ruotsalainen and Sampsa Pursiainen

    Citation: BioMedical Engineering OnLine 2019 18:116

    Content type: Research

    Published on:

  47. The Corvis® ST tonometer is an innovative device which, by combining a classic non-contact tonometer with an ultra-fast Scheimpflug camera, provides a number of parameters allowing for the assessment of corneal b...

    Authors: Magdalena Jędzierowska, Robert Koprowski, Sławomir Wilczyński and Katarzyna Krysik

    Citation: BioMedical Engineering OnLine 2019 18:115

    Content type: Research

    Published on: