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  1. The use of machine learning (ML) techniques in healthcare encompasses an emerging concept that envisages vast contributions to the tackling of rare diseases. In this scenario, amyotrophic lateral sclerosis (AL...

    Authors: Felipe Fernandes, Ingridy Barbalho, Daniele Barros, Ricardo Valentim, César Teixeira, Jorge Henriques, Paulo Gil and Mário Dourado Júnior

    Citation: BioMedical Engineering OnLine 2021 20:61

    Content type: Review

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  2. Peripheral nerve injury can cause significant impairment, and the current methods for facilitating repair, particularly over distances greater than approximately 1 mm, are not entirely effective. Allografts, a...

    Authors: Julia Towne, Nicklaus Carter and David J. Neivandt

    Citation: BioMedical Engineering OnLine 2021 20:60

    Content type: Research

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  3. Nebulizers are medical devices that deliver aerosolized medication directly to lungs to treat a variety of respiratory diseases. However, breathing patterns, respiration rates, airway diameters, and amounts of...

    Authors: Hyun Mok Park, Kyung Hwa Chang, Sang-Hyub Moon, Bong Joo Park, Sun Kook Yoo and Ki Chang Nam

    Citation: BioMedical Engineering OnLine 2021 20:59

    Content type: Research

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  4. To explore the analgesic efficacy of extracorporeal shock wave (ESW) combined with percutaneous vertebroplasty (PVP) after reduction in overextension position in the treatment of osteoporotic thoracolumbar com...

    Authors: Xiaowei Liu, Hui Wang, Yang Zhang, Mingling Wang, Yujin Qiu, Xiaodong Sun and Sheng Wang

    Citation: BioMedical Engineering OnLine 2021 20:58

    Content type: Research

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  5. Breast cancer is one of the most serious diseases threatening women’s health. Early screening based on ultrasound can help to detect and treat tumours in the early stage. However, due to the lack of radiologis...

    Authors: Xiaoyan Shen, He Ma, Ruibo Liu, Hong Li, Jiachuan He and Xinran Wu

    Citation: BioMedical Engineering OnLine 2021 20:57

    Content type: Research

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  6. The spinal nerve ligation (SNL) rat is well known as the most common rodent model of neuropathic pain without motor deficit. Researchers have performed analyses using only the von Frey and thermal withdrawal t...

    Authors: Takayuki Seto, Hidenori Suzuki, Tomoya Okazaki, Yasuaki Imajo, Norihiro Nishida, Masahiro Funaba, Tsukasa Kanchiku, Toshihiko Taguchi and Takashi Sakai

    Citation: BioMedical Engineering OnLine 2021 20:55

    Content type: Research

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  7. To develop a novel subjective–objective-combined (SOC) grading standard for auto-segmentation for each organ at risk (OAR) in the thorax.

    Authors: Yanchen Ying, Hao Wang, Hua Chen, Jianfan Cheng, Hengle Gu, Yan Shao, Yanhua Duan, Aihui Feng, Wen Feng, Xiaolong Fu, Hong Quan and Zhiyong Xu

    Citation: BioMedical Engineering OnLine 2021 20:54

    Content type: Research

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  8. Active human body models (AHBM) consider musculoskeletal movement and joint stiffness via active muscle truss elements in the finite element (FE) codes in dynamic application. In the latest models, such as THU...

    Authors: Niclas Trube, Werner Riedel and Matthias Boljen

    Citation: BioMedical Engineering OnLine 2021 20:53

    Content type: Research

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  9. Establishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an indep...

    Authors: Jingshu Ni, Haiou Hong, Yang Zhang, Shiqi Tang, Yongsheng Han, Zhaohui Fang, Yuanzhi Zhang, Nan Zhou, Quanfu Wang, Yong Liu, Zhongsheng Li, YiKun Wang and Meili Dong

    Citation: BioMedical Engineering OnLine 2021 20:52

    Content type: Research

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  10. Early detection of laryngeal masses without periodic visits to hospitals is essential for improving the possibility of full recovery and the long-term survival ratio after prompt treatment, as well as reducing...

    Authors: Gun Ho Kim, Eui-Suk Sung and Kyoung Won Nam

    Citation: BioMedical Engineering OnLine 2021 20:51

    Content type: Research

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  11. Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances. The correct diagn...

    Authors: Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade and Adriano Alves Pereira

    Citation: BioMedical Engineering OnLine 2021 20:50

    Content type: Research

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  12. Effective maintenance management of medical equipment is one of the major issues for quality of care, for providing cost-effective health services and for saving scarce resources. This study aimed to develop a...

    Authors: Morteza Arab-Zozani, Ali Imani, Leila Doshmangir, Koustuv Dalal and Rona Bahreini

    Citation: BioMedical Engineering OnLine 2021 20:49

    Content type: Research

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  13. Research on the degradation of silk fibroin (SF) scaffolds in vivo lacks uniform and effective standards and experimental evaluation methods. This study aims to evaluate the application of ultrasound in assess...

    Authors: Lihui Cai, Nan Gao, TingYu Sun, Ke Bi, Xin Chen and Xia Zhao

    Citation: BioMedical Engineering OnLine 2021 20:48

    Content type: Research

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  14. Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in th...

    Authors: Michael Neidlin, Sam Liao, Zhiyong Li, Benjamin Simpson, David M. Kaye, Ulrich Steinseifer and Shaun Gregory

    Citation: BioMedical Engineering OnLine 2021 20:47

    Content type: Research

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  15. Coronary stents are routinely placed in the treatment and prophylaxis of coronary artery disease (CAD). Current coronary stent designs are prone to developing blockages: in-stent thrombosis (IST) and in-stent ...

    Authors: Joseph Robert Stevens, Ava Zamani, James Ian Atkins Osborne, Reza Zamani and Mohammad Akrami

    Citation: BioMedical Engineering OnLine 2021 20:46

    Content type: Review

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  16. Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by ...

    Authors: Zhaoke Pi, Mengke Wang, Haoming Lin, Yanrong Guo, Siping Chen, Xianfen Diao, Hui Xia, Guoqiang Liu, Jie Zeng, Xinyu Zhang and Xin Chen

    Citation: BioMedical Engineering OnLine 2021 20:45

    Content type: Research

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  17. Cerebrovascular disease, in particular stroke, is a major public health challenge. An important biomarker is cerebral hemodynamics. To measure and quantify cerebral hemodynamics, however, only invasive, potent...

    Authors: Dietmar Frey, Michelle Livne, Heiko Leppin, Ela M. Akay, Orhun U. Aydin, Jonas Behland, Jan Sobesky, Peter Vajkoczy and Vince I. Madai

    Citation: BioMedical Engineering OnLine 2021 20:44

    Content type: Research

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  18. Recognition of facial expressions (FEs) plays a crucial role in social interactions. Most studies on FE recognition use static (image) stimuli, even though real-life FEs are dynamic. FE processing is complex a...

    Authors: Tuba Aktürk, Tom A. de Graaf, Yasemin Abra, Sevilay Şahoğlu-Göktaş, Dilek Özkan, Aysun Kula and Bahar Güntekin

    Citation: BioMedical Engineering OnLine 2021 20:41

    Content type: Research

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  19. Infertility is a significant problem of humanity. In vitro fertilisation is one of the most effective and frequently applied ART methods. The effectiveness IVF depends on the assessment and selection of gamete...

    Authors: Anna Targosz, Piotr Przystałka, Ryszard Wiaderkiewicz and Grzegorz Mrugacz

    Citation: BioMedical Engineering OnLine 2021 20:40

    Content type: Research

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  20. Small-incision lenticule extraction (SMILE) is a surgical procedure for the refractive correction of myopia and astigmatism, which has been reported as safe and effective. However, over- and under-correction s...

    Authors: Seungbin Park, Hannah Kim, Laehyun Kim, Jin-kuk Kim, In Sik Lee, Ik Hee Ryu and Youngjun Kim

    Citation: BioMedical Engineering OnLine 2021 20:38

    Content type: Research

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  21. Low-dose X-ray images have become increasingly popular in the last decades, due to the need to guarantee the lowest reasonable patient’s exposure. Dose reduction causes a substantial increase of quantum noise,...

    Authors: Emilio Andreozzi, Antonio Fratini, Daniele Esposito, Mario Cesarelli and Paolo Bifulco

    Citation: BioMedical Engineering OnLine 2021 20:36

    Content type: Research

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  22. Coronary plaque vulnerability prediction is difficult because plaque vulnerability is non-trivial to quantify, clinically available medical image modality is not enough to quantify thin cap thickness, predicti...

    Authors: Xiaoya Guo, Akiko Maehara, Mitsuaki Matsumura, Liang Wang, Jie Zheng, Habib Samady, Gary S. Mintz, Don P. Giddens and Dalin Tang

    Citation: BioMedical Engineering OnLine 2021 20:34

    Content type: Research

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  23. MXene is a recently emerged multifaceted two-dimensional (2D) material that is made up of surface-modified carbide, providing its flexibility and variable composition. They consist of layers of early transitio...

    Authors: Adibah Zamhuri, Gim Pao Lim, Nyuk Ling Ma, Kian Sek Tee and Chin Fhong Soon

    Citation: BioMedical Engineering OnLine 2021 20:33

    Content type: Review

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  24. Unified Parkinson Disease Rating Scale-part III (UPDRS III) is part of the standard clinical examination performed to track the severity of Parkinson’s disease (PD) motor complications. Wearable technologies c...

    Authors: Murtadha D. Hssayeni, Joohi Jimenez-Shahed, Michelle A. Burack and Behnaz Ghoraani

    Citation: BioMedical Engineering OnLine 2021 20:32

    Content type: Research

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  25. The use of machine learning (ML) methods would improve the diagnosis of respiratory changes in systemic sclerosis (SSc). This paper evaluates the performance of several ML algorithms associated with the respir...

    Authors: Domingos S. M. Andrade, Luigi Maciel Ribeiro, Agnaldo J. Lopes, Jorge L. M. Amaral and Pedro L. Melo

    Citation: BioMedical Engineering OnLine 2021 20:31

    Content type: Research

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  26. The regulation and control of pressure stimuli is useful for many studies of pain and nociception especially those in the visceral pain field. In many in vivo experiments, distinct air and liquid stimuli at va...

    Authors: Michael DeLong, Mauricio Gil-Silva, Veronica Minsu Hong, Olivia Babyok and Benedict J. Kolber

    Citation: BioMedical Engineering OnLine 2021 20:30

    Content type: Research

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  27. As an object’s electrical passive property, the electrical conductivity is proportional to the mobility and concentration of charged carriers that reflect the brain micro-structures. The measured multi-b diffusio...

    Authors: Mun Bae Lee, Hyung Joong Kim and Oh In Kwon

    Citation: BioMedical Engineering OnLine 2021 20:29

    Content type: Research

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  28. The structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contra...

    Authors: Qiang Tao, Chenchen Gao, Xuehong Tong, Shizhen Yuan and Jingdong Xu

    Citation: BioMedical Engineering OnLine 2021 20:28

    Content type: Research

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  29. Lung ultrasound (LUS) can be an important imaging tool for the diagnosis and assessment of lung involvement. Ultrasound sonograms have been confirmed to illustrate damage to a person’s lungs, which means that ...

    Authors: Zhaoyu Hu, Zhenhua Liu, Yijie Dong, Jianjian Liu, Bin Huang, Aihua Liu, Jingjing Huang, Xujuan Pu, Xia Shi, Jinhua Yu, Yang Xiao, Hui Zhang and Jianqiao Zhou

    Citation: BioMedical Engineering OnLine 2021 20:27

    Content type: Research

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  30. Fresh stillbirths (FSB) and very early neonatal deaths (VEND) are important global challenges with 2.6 million deaths annually. The vast majority of these deaths occur in low- and low-middle income countries. ...

    Authors: Jarle Urdal, Kjersti Engan, Trygve Eftestøl, Solveig H. Haaland, Benjamin Kamala, Paschal Mdoe, Hussein Kidanto and Hege Ersdal

    Citation: BioMedical Engineering OnLine 2021 20:26

    Content type: Research

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  31. Electrical pulse stimulations have been applied in brain for treating certain diseases such as movement disorders. High-frequency stimulations (HFS) of biphasic pulses have been used in clinic stimulations, su...

    Authors: Yue Yuan, Lvpiao Zheng, Zhouyan Feng and Gangsheng Yang

    Citation: BioMedical Engineering OnLine 2021 20:25

    Content type: Research

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  32. Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extr...

    Authors: Xin Zhao, Qirui Wu, Xiuqing Gong, Jinfeng Liu and Yujie Ma

    Citation: BioMedical Engineering OnLine 2021 20:24

    Content type: Review

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  33. Precise visualization of meshes and their position would greatly aid in mesh shrinkage evaluation, hernia recurrence risk assessment, and the preoperative planning of salvage repair. Lightweight (LW) meshes ar...

    Authors: Jiting Yang, Haiyan Li, Jun Wu, Liang Sun, Dan Xu, Yuanyuan Wang, Yufeng Zhang, Yue Chen and Lin Chen

    Citation: BioMedical Engineering OnLine 2021 20:23

    Content type: Research

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  34. The detection and dissection of epidermal subgroups could lead to an improved understanding of skin homeostasis and wound healing. Flow cytometric analysis provides an effective method to detect the surface ma...

    Authors: Lidan Zhang, Ying Cen, Qiaorong Huang, Huifang Li, Xianming Mo, Wentong Meng and Junjie Chen

    Citation: BioMedical Engineering OnLine 2021 20:22

    Content type: Research

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  35. Over the last decades, microRNAs (miRNAs) have emerged as important molecules associated with the regulation of gene expression in humans and other organisms, expanding the strategies available to diagnose and...

    Authors: Leonardo J. Galvão-Lima, Antonio H. F. Morais, Ricardo A. M. Valentim and Elio J. S. S. Barreto

    Citation: BioMedical Engineering OnLine 2021 20:21

    Content type: Review

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  36. Self-esteem is the individual evaluation of oneself. People with high self-esteem grade have mental health and can bravely cope with the threats from the environment. With the development of neuroimaging techn...

    Authors: Bo Peng, Gaofeng Pang, Aditya Saxena, Yan Liu, Baohua Hu, Suhong Wang and Yakang Dai

    Citation: BioMedical Engineering OnLine 2021 20:20

    Content type: Research

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  37. Cone-shaped vena cava filters (VCFs) are widely used to treat venous thromboembolism. However, in the long term, the problem of occlusion persists even after the filter is deployed. A previous study hypothesiz...

    Authors: Ying Chen, Zaipin Xu, Xiaoyan Deng, Shibo Yang, Wenchang Tan, Yubo Fan, Yong Han and Yubin Xing

    Citation: BioMedical Engineering OnLine 2021 20:19

    Content type: Research

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  38. Advances in regenerative medicine technologies have been strongly proposed in the management of thyroid diseases. Mechanistically, the adoption of thyroid bioengineering requires a scaffold that shares a simil...

    Authors: Jie Weng, Bi Chen, Mengying Xie, Xinlong Wan, Peng Wang, Xiaoming Zhou, Zhiliang Zhou, Jin Mei, Liang Wang, Duping Huang, Zhibin Wang, Zhiyi Wang and Chan Chen

    Citation: BioMedical Engineering OnLine 2021 20:18

    Content type: Research

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  39. The tongue and hard palate play an essential role in the production of sound during continuous speech. Appropriate tongue and hard palate contacts will ensure proper sound production. Electropalatography, also...

    Authors: Syatirah Mat Zin, S. Z. Md Rasib, Fatanah M. Suhaimi and M. Mariatti

    Citation: BioMedical Engineering OnLine 2021 20:17

    Content type: Review

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  40. Intravascular ultrasound (IVUS) is the golden standard in accessing the coronary lesions, stenosis, and atherosclerosis plaques. In this paper, a fully automatic approach by an 8-layer U-Net is developed to se...

    Authors: Liang Dong, Wenbing Jiang, Wei Lu, Jun Jiang, Ya Zhao, Xiangfen Song, Xiaochang Leng, Hang Zhao, Jian’an Wang, Changling Li and Jianping Xiang

    Citation: BioMedical Engineering OnLine 2021 20:16

    Content type: Research

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  41. The objective of the study was to validate biomechanical characteristics of a 3D-printed, novel-designated fixation plate for treating mandibular angle fracture, and compare it with two commonly used fixation ...

    Authors: Xu Xu, Kang-jie Cheng, Yun-feng Liu, Ying-ying Fan, Joanne H. Wang, Russell Wang, Dale A. Baur, Xian-feng Jiang and Xing-tao Dong

    Citation: BioMedical Engineering OnLine 2021 20:15

    Content type: Research

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  42. The lower extremities of the body often suffer from impaired microcirculation, particularly in the elderly or people with underlying conditions such as diabetes. Especially for people suffering from peripheral...

    Authors: Weiyan Ren, Liqiang Xu, Xuan Zheng, Fang Pu, Deyu Li and Yubo Fan

    Citation: BioMedical Engineering OnLine 2021 20:14

    Content type: Research

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  43. Recently, error-related negativity (ERN) signals are proposed to develop an assist-as-needed robotic stroke rehabilitation program. Stroke patients’ state-of-mind, such as motivation to participate and active ...

    Authors: Akshay Kumar, Qiang Fang and Elena Pirogova

    Citation: BioMedical Engineering OnLine 2021 20:13

    Content type: Research

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  44. Atrial fibrillation (AF) represents the most common arrhythmia worldwide, related to increased risk of ischemic stroke or systemic embolism. It is critical to screen and diagnose AF for the benefits of better ...

    Authors: Fangfang Jiang, Chuhang Hong, Tianqing Cheng, Haoqian Wang, Bowen Xu and Biyong Zhang

    Citation: BioMedical Engineering OnLine 2021 20:12

    Content type: Research

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