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  1. Acoustic cavitation plays an important role in the medical treatment using high-intensity focused ultrasound (HIFU), but unnecessarily strong cavitation also could deform the morphology and enlarge the size of...

    Authors: Min He, Zhiqiang Zhong, Deping Zeng, Xiaobo Gong, Zhibiao Wang and Faqi Li

    Citation: BioMedical Engineering OnLine 2021 20:91

    Content type: Research

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  2. Ataxic gait is one of the most common and disabling symptoms in people with degenerative cerebellar ataxia. Intensive and well-coordinated inpatient rehabilitation improves ataxic gait. In addition to therapis...

    Authors: Akira Matsushima, Yoichi Maruyama, Noriaki Mizukami, Mikio Tetsuya, Minoru Hashimoto and Kunihiro Yoshida

    Citation: BioMedical Engineering OnLine 2021 20:90

    Content type: Research

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  3. Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role of hy...

    Authors: Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Meng Yan and Jun Xiao

    Citation: BioMedical Engineering OnLine 2021 20:88

    Content type: Research

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  4. Ovarian cancer is one of the most common gynecological malignancies with the high morbidity and mortality. This study was aimed to explore the role of non-structure maintenance of chromosomes condensin I compl...

    Authors: Yingying Qi, Kexin Mo and Ting Zhang

    Citation: BioMedical Engineering OnLine 2021 20:83

    Content type: Research

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  5. The effect of the COVID-19 pandemic on higher education has been felt worldwide. There are many lessons to be learned about teaching and learning in the digital age. While we evaluate the full impact and prepa...

    Authors: Seema Biswas, Oren Dahan, Evgeny Solomonov, Igor Waksman and Orit Braun Benyamin

    Citation: BioMedical Engineering OnLine 2021 20:82

    Content type: Review

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  6. Knee osteoarthritis (KOA) is a common cause of disability among the elderly. We aimed to explore the effects of aldehyde dehydrogenase (ALDH) 2 on the progression of KOA and identifying the potential mechanisms.

    Authors: Lingxiao Pan, Wei Ding, Jie Li, Kaifeng Gan, Yandong Shen, Junxiang Xu and Minzhe Zheng

    Citation: BioMedical Engineering OnLine 2021 20:80

    Content type: Research

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  7. Anterior resection syndrome (ARS) is characterized by the diverse and interchangeable evacuatory symptoms that may occur following distal colorectal resection. We aimed to investigate the effect and potential ...

    Authors: Wei Zhang, Meng Wu, Peng Chen, Jiamin Zhang, Jiaze Ma, Yile Cheng, Xiaoliu Li, Junjie Hu, Wanli Li, Yuxin Du, Kang Ding and Zhimin Fan

    Citation: BioMedical Engineering OnLine 2021 20:79

    Content type: Research

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  8. Fractional flow reserve (FFR) is a widely used gold standard to evaluate ischemia-causing lesions. A new method of non-invasive approach, termed as AccuFFRct, for calculating FFR based on coronary computed tomogr...

    Authors: Wenbing Jiang, Yibin Pan, Yumeng Hu, Xiaochang Leng, Jun Jiang, Li Feng, Yongqing Xia, Yong Sun, Jian’an Wang, Jianping Xiang and Changling Li

    Citation: BioMedical Engineering OnLine 2021 20:77

    Content type: Research

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  9. Phytochemical agents such as thymoquinone (TQ) have osteogenic property. This study aimed to investigate the synergic impact of TQ and hydroxyapatite on mesenchymal stem cell differentiation. Alginate was also...

    Authors: Ebrahim Rahmani-Moghadam, Tahereh Talaei-Khozani, Vahideh Zarrin and Zahra Vojdani

    Citation: BioMedical Engineering OnLine 2021 20:76

    Content type: Research

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  10. Schizophrenia is a chronic and severe mental disease, which largely influences the daily life and work of patients. Clinically, schizophrenia with negative symptoms is usually misdiagnosed. The diagnosis is al...

    Authors: Jia Fu, Sen Yang, Fei He, Ling He, Yuanyuan Li, Jing Zhang and Xi Xiong

    Citation: BioMedical Engineering OnLine 2021 20:75

    Content type: Research

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  11. Cerebral edema is a common condition secondary to any type of neurological injury. The early diagnosis and monitoring of cerebral edema is of great importance to improve the prognosis. In this article, a flexi...

    Authors: Jingbo Chen, Gen Li, Huayou Liang, Shuanglin Zhao, Jian Sun and Mingxin Qin

    Citation: BioMedical Engineering OnLine 2021 20:74

    Content type: Research

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  12. Using Ambient Assisted Living sensors to detect acute stress could help people mitigate the harmful effects of everyday stressful situations. This would help both the healthy and those affected more by sudden ...

    Authors: Benedek Szakonyi, István Vassányi, Edit Schumacher and István Kósa

    Citation: BioMedical Engineering OnLine 2021 20:73

    Content type: Research

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  13. The visualization and analysis of brain data such as white matter diffusion tractography and magnetic resonance imaging (MRI) volumes is commonly used by neuro-specialist and researchers to help the understand...

    Authors: Ignacio Osorio, Miguel Guevara, Danilo Bonometti, Diego Carrasco, Maxime Descoteaux, Cyril Poupon, Jean-François Mangin, Cecilia Hernández and Pamela Guevara

    Citation: BioMedical Engineering OnLine 2021 20:72

    Content type: Software

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  14. The classification of benign and malignant microcalcification clusters (MCs) is an important task for computer-aided diagnosis (CAD) of digital breast tomosynthesis (DBT) images. Influenced by imaging method, ...

    Authors: Bingbing Xiao, Haotian Sun, You Meng, Yunsong Peng, Xiaodong Yang, Shuangqing Chen, Zhuangzhi Yan and Jian Zheng

    Citation: BioMedical Engineering OnLine 2021 20:71

    Content type: Research

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  15. The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus impr...

    Authors: Jungang Li, Chaoqian Zhao, Chun Liu, Zhenyu Wang, Zeming Ling, Bin Lin, Bizhi Tan, Linquan Zhou, Yan Chen, Delong Liu, Xuenong Zou and Wenge Liu

    Citation: BioMedical Engineering OnLine 2021 20:70

    Content type: Research

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  16. Hypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement fibrosis, impaired contractility, and elevated filling pressures. These var...

    Authors: Ekaterina Kovacheva, Tobias Gerach, Steffen Schuler, Marco Ochs, Olaf Dössel and Axel Loewe

    Citation: BioMedical Engineering OnLine 2021 20:69

    Content type: Research

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  17. Continuous long-term electrocardiography monitoring has been increasingly recognized for early diagnosis and management of different types of cardiovascular diseases. To find an alternative to Ag/AgCl gel elec...

    Authors: Milad Alizadeh-Meghrazi, Binbin Ying, Alessandra Schlums, Emily Lam, Ladan Eskandarian, Farhana Abbas, Gurjant Sidhu, Amin Mahnam, Bastien Moineau and Milos R. Popovic

    Citation: BioMedical Engineering OnLine 2021 20:68

    Content type: Research

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  18. Hepatocellular carcinoma (HCC) is currently the sixth most common malignancy and the second major cause of tumor-related deaths in the world. This study aimed to investigate the role of cleavage and polyadenyl...

    Authors: Yang Liu, Hongbo Zou, Qichao Xie, Lan Zou, Rui Kong and Bijing Mao

    Citation: BioMedical Engineering OnLine 2021 20:67

    Content type: Research

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  19. To provide surgical support for corrective osteotomy, we developed an image fusion system for three-dimensional (3D) preoperative planning and fluoroscopy. To assess the utility of this image fusion system, we...

    Authors: Yuichi Yoshii, Takeshi Ogawa, Yuki Hara, Yasukazu Totoki and Tomoo Ishii

    Citation: BioMedical Engineering OnLine 2021 20:66

    Content type: Research

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  20. This study used machine learning classification of texture features from MRI of breast tumor and peri-tumor at multiple treatment time points in conjunction with molecular subtypes to predict eventual patholog...

    Authors: Lal Hussain, Pauline Huang, Tony Nguyen, Kashif J. Lone, Amjad Ali, Muhammad Salman Khan, Haifang Li, Doug Young Suh and Tim Q. Duong

    Citation: BioMedical Engineering OnLine 2021 20:63

    Content type: Research

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  21. Pathological gaits of children may lead to terrible diseases, such as osteoarthritis or scoliosis. By monitoring the gait pattern of a child, proper therapeutic measures can be recommended to avoid the terribl...

    Authors: Linghui Xu, Jiansong Chen, Fei Wang, Yuting Chen, Wei Yang and Canjun Yang

    Citation: BioMedical Engineering OnLine 2021 20:62

    Content type: Research

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  22. The use of machine learning (ML) techniques in healthcare encompasses an emerging concept that envisages vast contributions to the tackling of rare diseases. In this scenario, amyotrophic lateral sclerosis (AL...

    Authors: Felipe Fernandes, Ingridy Barbalho, Daniele Barros, Ricardo Valentim, César Teixeira, Jorge Henriques, Paulo Gil and Mário Dourado Júnior

    Citation: BioMedical Engineering OnLine 2021 20:61

    Content type: Review

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  23. Peripheral nerve injury can cause significant impairment, and the current methods for facilitating repair, particularly over distances greater than approximately 1 mm, are not entirely effective. Allografts, a...

    Authors: Julia Towne, Nicklaus Carter and David J. Neivandt

    Citation: BioMedical Engineering OnLine 2021 20:60

    Content type: Research

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  24. Nebulizers are medical devices that deliver aerosolized medication directly to lungs to treat a variety of respiratory diseases. However, breathing patterns, respiration rates, airway diameters, and amounts of...

    Authors: Hyun Mok Park, Kyung Hwa Chang, Sang-Hyub Moon, Bong Joo Park, Sun Kook Yoo and Ki Chang Nam

    Citation: BioMedical Engineering OnLine 2021 20:59

    Content type: Research

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  25. To explore the analgesic efficacy of extracorporeal shock wave (ESW) combined with percutaneous vertebroplasty (PVP) after reduction in overextension position in the treatment of osteoporotic thoracolumbar com...

    Authors: Xiaowei Liu, Hui Wang, Yang Zhang, Mingling Wang, Yujin Qiu, Xiaodong Sun and Sheng Wang

    Citation: BioMedical Engineering OnLine 2021 20:58

    Content type: Research

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  26. Breast cancer is one of the most serious diseases threatening women’s health. Early screening based on ultrasound can help to detect and treat tumours in the early stage. However, due to the lack of radiologis...

    Authors: Xiaoyan Shen, He Ma, Ruibo Liu, Hong Li, Jiachuan He and Xinran Wu

    Citation: BioMedical Engineering OnLine 2021 20:57

    Content type: Research

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  27. The spinal nerve ligation (SNL) rat is well known as the most common rodent model of neuropathic pain without motor deficit. Researchers have performed analyses using only the von Frey and thermal withdrawal t...

    Authors: Takayuki Seto, Hidenori Suzuki, Tomoya Okazaki, Yasuaki Imajo, Norihiro Nishida, Masahiro Funaba, Tsukasa Kanchiku, Toshihiko Taguchi and Takashi Sakai

    Citation: BioMedical Engineering OnLine 2021 20:55

    Content type: Research

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  28. To develop a novel subjective–objective-combined (SOC) grading standard for auto-segmentation for each organ at risk (OAR) in the thorax.

    Authors: Yanchen Ying, Hao Wang, Hua Chen, Jianfan Cheng, Hengle Gu, Yan Shao, Yanhua Duan, Aihui Feng, Wen Feng, Xiaolong Fu, Hong Quan and Zhiyong Xu

    Citation: BioMedical Engineering OnLine 2021 20:54

    Content type: Research

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  29. Active human body models (AHBM) consider musculoskeletal movement and joint stiffness via active muscle truss elements in the finite element (FE) codes in dynamic application. In the latest models, such as THU...

    Authors: Niclas Trube, Werner Riedel and Matthias Boljen

    Citation: BioMedical Engineering OnLine 2021 20:53

    Content type: Research

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  30. Establishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an indep...

    Authors: Jingshu Ni, Haiou Hong, Yang Zhang, Shiqi Tang, Yongsheng Han, Zhaohui Fang, Yuanzhi Zhang, Nan Zhou, Quanfu Wang, Yong Liu, Zhongsheng Li, YiKun Wang and Meili Dong

    Citation: BioMedical Engineering OnLine 2021 20:52

    Content type: Research

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  31. Early detection of laryngeal masses without periodic visits to hospitals is essential for improving the possibility of full recovery and the long-term survival ratio after prompt treatment, as well as reducing...

    Authors: Gun Ho Kim, Eui-Suk Sung and Kyoung Won Nam

    Citation: BioMedical Engineering OnLine 2021 20:51

    Content type: Research

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  32. Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances. The correct diagn...

    Authors: Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade and Adriano Alves Pereira

    Citation: BioMedical Engineering OnLine 2021 20:50

    Content type: Research

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  33. Effective maintenance management of medical equipment is one of the major issues for quality of care, for providing cost-effective health services and for saving scarce resources. This study aimed to develop a...

    Authors: Morteza Arab-Zozani, Ali Imani, Leila Doshmangir, Koustuv Dalal and Rona Bahreini

    Citation: BioMedical Engineering OnLine 2021 20:49

    Content type: Research

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  34. Research on the degradation of silk fibroin (SF) scaffolds in vivo lacks uniform and effective standards and experimental evaluation methods. This study aims to evaluate the application of ultrasound in assess...

    Authors: Lihui Cai, Nan Gao, TingYu Sun, Ke Bi, Xin Chen and Xia Zhao

    Citation: BioMedical Engineering OnLine 2021 20:48

    Content type: Research

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  35. Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in th...

    Authors: Michael Neidlin, Sam Liao, Zhiyong Li, Benjamin Simpson, David M. Kaye, Ulrich Steinseifer and Shaun Gregory

    Citation: BioMedical Engineering OnLine 2021 20:47

    Content type: Research

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  36. Coronary stents are routinely placed in the treatment and prophylaxis of coronary artery disease (CAD). Current coronary stent designs are prone to developing blockages: in-stent thrombosis (IST) and in-stent ...

    Authors: Joseph Robert Stevens, Ava Zamani, James Ian Atkins Osborne, Reza Zamani and Mohammad Akrami

    Citation: BioMedical Engineering OnLine 2021 20:46

    Content type: Review

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  37. Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by ...

    Authors: Zhaoke Pi, Mengke Wang, Haoming Lin, Yanrong Guo, Siping Chen, Xianfen Diao, Hui Xia, Guoqiang Liu, Jie Zeng, Xinyu Zhang and Xin Chen

    Citation: BioMedical Engineering OnLine 2021 20:45

    Content type: Research

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  38. Cerebrovascular disease, in particular stroke, is a major public health challenge. An important biomarker is cerebral hemodynamics. To measure and quantify cerebral hemodynamics, however, only invasive, potent...

    Authors: Dietmar Frey, Michelle Livne, Heiko Leppin, Ela M. Akay, Orhun U. Aydin, Jonas Behland, Jan Sobesky, Peter Vajkoczy and Vince I. Madai

    Citation: BioMedical Engineering OnLine 2021 20:44

    Content type: Research

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