Ultrasound (US) therapy may improve osteoarthritis symptoms. We investigated the effects of US on the synovial fluid (SF) proteome in a rabbit knee osteoarthritis (KOA) model to explore its therapeutic mechani...
Authors: Qinglu Luo, Shuangquan Ji, Zhimi Li, Tao Huang, Siqin Fan and Qin Xi
Non-contact tonometers based on the method using air puff and Scheimpflug’s fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of...
Authors: Magdalena Jędzierowska and Robert Koprowski
Cervical cancer is preventable if effective screening measures are in place. Pap-smear is the commonest technique used for early screening and diagnosis of cervical cancer. However, the manual analysis of the ...
Authors: Wasswa William, Andrew Ware, Annabella Habinka Basaza-Ejiri and Johnes Obungoloch
Serial electrocardiography aims to contribute to electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made ECG in the same individual. Here, we present a novel algorithm...
Authors: Agnese Sbrollini, Marjolein C. De Jongh, C. Cato Ter Haar, Roderick W. Treskes, Sumche Man, Laura Burattini and Cees A. Swenne
While spontaneous robotic arm control using motor imagery has been reported, most previous successful cases have used invasive approaches with advantages in spatial resolution. However, still many researchers ...
Authors: Yoon Jae Kim, Hyung Seok Nam, Woo Hyung Lee, Han Gil Seo, Ja-Ho Leigh, Byung-Mo Oh, Moon Suk Bang and Sungwan Kim
My Diabetes My Way (MDMW) is the National Health Service (NHS) Scotland website for people with diabetes and their carers. It consists of an interactive information website and an electronic personal health re...
Authors: Scott Gordon Cunningham, Massimo Brillante, Brian Allardice, Nicholas Conway, Ritchie Robert McAlpine and Deborah Jane Wake
Arterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measu...
Authors: Yang Liu, Ze Wang, Ruihua Liang, Zhengrong Liang and Hongbing Lu
Docetaxel (DTX) is an anticancer drug that is currently formulated with polysorbate 80 and ethanol (50:50, v/v) in clinical use. Unfortunately, this formulation causes hypersensitivity reactions, leading to se...
Authors: Na Qu, Yating Sun, Yujing Li, Fei Hao, Pengyu Qiu, Lesheng Teng, Jing Xie and Yin Gao
Simulation of a left ventricle has become a critical facet of evaluating therapies and operations that interact with cardiac performance. The ability to simulate a wide range of possible conditions, changes in...
Authors: Jacob M. King, Clint A. Bergeron and Charles E. Taylor
Acute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways r...
Authors: Zhihua Liu, Chenguang Ma, Junhua Gu and Ming Yu
Quantizing the Breast Imaging Reporting and Data System (BI-RADS) criteria into different categories with the single ultrasound modality has always been a challenge. To achieve this, we proposed a two-stage gr...
Ultrasound computed tomography (USCT) is usually realized with a ring array. It can provide better imaging performance and more tissue information by emitting and receiving the ultrasound signal in different d...
Authors: Xinming Jiang, Yang Xiao, Yuanyuan Wang, Jinhua Yu and Hairong Zheng
Segmenting the hippocampal subfields accurately from brain magnetic resonance (MR) images is a challenging task in medical image analysis. Due to the small structural size and the morphological complexity of t...
Prolonged static sitting in wheelchairs increases the risk of pressure ulcers. This exploratory study proposed three dynamic sitting techniques in order to reduce the risk of developing pressure ulcer during w...
Authors: Chun-Ting Li, Yen-Nien Chen, Yen-Ting Tseng and Kuen-Horng Tsai
A direct blow to the knee is one way to injure the anterior cruciate ligament (ACL), e.g., during a football or traffic accident. Robot-assisted therapy (RAT) rehabilitation, simulating regular walking, improv...
Authors: Juan C. Yepes, Mario A. Portela, Álvaro J. Saldarriaga, Vera Z. Pérez and Manuel J. Betancur
Lung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma...
Authors: Mingjie Xu, Shouliang Qi, Yong Yue, Yueyang Teng, Lisheng Xu, Yudong Yao and Wei Qian
There exists a growing need for a cost-effective, reliable, and portable pulsation simulator that can generate a wide variety of pulses depending on age and cardiovascular disease. For constructing compact pul...
Authors: Tae-Heon Yang, Gwanghyun Jo, Jeong-Hoi Koo, Sam-Yong Woo, Jaeuk U. Kim and Young-Min Kim
Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescen...
Authors: Kedi Zhou, Yichen Ding, Ivan Vuletic, Yonglu Tian, Jun Li, Jinghao Liu, Yixing Huang, Hongfang Sun, Changhui Li, Qiushi Ren and Yanye Lu
Electrical impedance tomography (EIT) is an emerging imaging technology that has been used to monitor brain injury and detect acute stroke. The time and frequency properties of electrode–skin contact impedance...
Authors: Lin Yang, Heng Li, Junjie Ding, Weichen Li, Xiuzhen Dong, Zhihong Wen and Xuetao Shi
Detection and quantification of cyclic alternating patterns (CAP) components has the potential to serve as a disease bio-marker. Few methods exist to discriminate all the different CAP components, they do not ...
Authors: Fátima Machado, Francisco Sales, Clara Santos, António Dourado and C. A. Teixeira
Phase-rectified signal averaging (PRSA) was often applied to assess the cardiac vagal modulation. Despite its broad use, this method suffers from the confounding effects of anomalous variants of sinus rhythm. ...
Authors: Hongyun Liu, Ping Zhan, Jinlong Shi, Guojing Wang, Buqing Wang and Weidong Wang
Mobile health apps (mHealth apps) are increasing in popularity and utility for the management of many chronic diseases. Although the current reimbursement structure for mHealth apps is lagging behind the rapid...
Authors: Alice Lan, Alexandra Lee, Kristin Munroe, Cameron McRae, Linda Kaleis, Karim Keshavjee and Aziz Guergachi
Myocardial deformation measured by strain is used to detect electro-mechanical abnormalities in cardiac tissue. Estimation of myocardial properties from regional strain patterns when multiple pathologies are p...
Authors: Borut Kirn, John Walmsley and Joost Lumens
Imbalanced data classification is an inevitable problem in medical intelligent diagnosis. Most of real-world biomedical datasets are usually along with limited samples and high-dimensional feature. This seriou...
Authors: Liyuan Zhang, Huamin Yang and Zhengang Jiang
The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction of hemodynamic responses (HRs...
Authors: Hoang-Dung Nguyen, So-Hyeon Yoo, M. Raheel Bhutta and Keum-Shik Hong
The purpose of this study is to explore the potential of phase contrast imaging to detect fibrotic progress in its early stage; to investigate the feasibility of texture features for quantified diagnosis of li...
Authors: Jing Wang, Ming Wang, Song Gao and Hui Li
Sit-to-stand movements are a necessary part of daily life, and excessive mechanical stress on the articular cartilage has been reported to encourage the progression of osteoarthritis. Although a change in hip ...
Authors: Takuma Inai, Tomoya Takabayashi, Mutsuaki Edama and Masayoshi Kubo
This paper presents a novel method for early detection of hematomas using highly sensitive optical fNIR imaging methods based on broadband photon migration. The NIR experimental measurements of inhomogeneous m...
Authors: E. Sultan, A. H. Gandjbakhche, K. Pourrezaei and A. S. Daryoush
Cervical cancer is the fifth most common cancer among women, which is the third leading cause of cancer death in women worldwide. Brachytherapy is the most effective treatment for cervical cancer. For brachyth...
Authors: Xia Huang, Jian Wang, Fan Tang, Tao Zhong and Yu Zhang
A number of various techniques were proposed to stabilized ankle arthrodesis, among them external and internal fixation. Appropriate balance and adequate distribution of lower limb loads determine normal biome...
Authors: Piotr Morasiewicz, Grzegorz Konieczny, Maciej Dejnek, Leszek Morasiewicz, Wiktor Urbański, Mirosław Kulej, Szymon Łukasz Dragan, Szymon Feliks Dragan and Łukasz Pawik
Preparation of a uniform angle of walls is essential for making an ideal convergence angle in fixed prosthodontics. We developed a de novo detachable angle-correction apparatus for dental handpiece drills that...
The periodontal ligament (PDL) plays a key role in alveolar bone remodeling and resorption during tooth movements. The prediction of tooth mobility under functional dental loads requires a deep understanding o...
Authors: Bin Wu, Yipeng Fu, Haotian Shi, Bin Yan, Ruxin Lu, Songyun Ma and Bernd Markert
This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical di...
Authors: Shaun Davidson, Chris Pretty, Joel Balmer, Thomas Desaive and J. Geoffrey Chase
Robot-assisted minimally invasive surgery (RMIS) is promising for improving surgical accuracy and dexterity. As the end effector of the robotic arm, the remote centre of motion mechanism is one of the requisit...
Authors: Xiaoqin Zhou, Haijun Zhang, Mei Feng, Ji Zhao and Yili Fu
Extracting fundamental information from data, thus underlining hidden structures or removing noisy information, is one of the most important aims in different scientific fields especially in biological and med...
Authors: Nicola Amoroso, Domenico Diacono, Marianna La Rocca, Roberto Bellotti and Sabina Tangaro
In case of significant imperfections on the cornea, data acquisition is difficult and a significant level of missing data could require the interpolation of important areas of the cornea, resulting in a very a...
Authors: Francisco Cavas-Martínez, Daniel G. Fernández-Pacheco, Dolores Parras, Francisco J. F. Cañavate, Laurent Bataille and Jorge Alió
Like other scientific fields, such as cosmology, high-energy physics, or even the life sciences, medicine and healthcare face the challenge of an extremely quick transformation into data-driven sciences. This ...
Authors: Alfredo Vellido, Vicent Ribas, Carles Morales, Adolfo Ruiz Sanmartín and Juan Carlos Ruiz Rodríguez
Laboratory rats play a critical role in research because they provide a biological model that can be used for evaluating the affectation of diseases and injuries, and for the evaluation of the effectiveness of...
Authors: S. Ivvan Valdez, Josué González-Sandoval, Sergio Dueñas-Jiménez, Nancy Elizabeth Franco Rodríguez, Sulema Torres-Ramos and Gerardo Mendizabal-Ruiz
Pseudomonas aeruginosa is a common bacterium which is recognized for its association with hospital-acquired infections and its advanced antibiotic resistance mechanisms. Tuberculosis, one of the major causes of m...
The human activity monitoring technology is one of the most important technologies for ambient assisted living, surveillance-based security, sport and fitness activities, healthcare of elderly people. The acti...
Authors: Giorgio Biagetti, Paolo Crippa, Laura Falaschetti, Simone Orcioni and Claudio Turchetti
This paper studies the temporal consistency of health care expenditures in a large state Medicaid program. Predictive machine learning models were used to forecast the expenditures, especially for the high-cos...
Authors: Chengliang Yang, Chris Delcher, Elizabeth Shenkman and Sanjay Ranka
Mechanical ventilation is an essential therapy to support critically ill respiratory failure patients. Current standards of care consist of generalised approaches, such as the use of positive end expiratory pr...
Authors: Vincent J. Major, Yeong Shiong Chiew, Geoffrey M. Shaw and J. Geoffrey Chase
The main objective of this paper is to develop and test the ability of the Leap Motion controller (LMC) to assess the motor dysfunction in patients with Parkinson disease (PwPD) based on the MDS-UPDRSIII exerc...
Authors: A. H. Butt, E. Rovini, C. Dolciotti, G. De Petris, P. Bongioanni, M. C. Carboncini and F. Cavallo
After publication, it was highlighted that the original publication [1] contained a spelling mistake in the first name of Marcelo Gattas. This was incorrectly captured as Marelo Gattass in the original article...
Authors: Alex M. Santos, Anselmo C. Paiva, Adriana P. M. Santos, Steve A. T. Mpinda, Daniel L. Gomes Jr., Aristófanes C. Silva, Geraldo Braz Jr., João Dallyson S. de Almeida and Marcelo Gattas
Biomedical named entity recognition (Bio-NER) is a fundamental task in handling biomedical text terms, such as RNA, protein, cell type, cell line, and DNA. Bio-NER is one of the most elementary and core tasks ...
Authors: Hye-Jeong Song, Byeong-Cheol Jo, Chan-Young Park, Jong-Dae Kim and Yu-Seop Kim
In this paper, we propose a system for data monitoring and control of polymerase chain reaction (PCR) externally. PCR is a technique for amplifying a desired DNA molecule by repeatedly synthesizing a specific ...
Authors: Jong-Dae Kim, So-Yeon Lee, Yu-Seop Kim, Hye-Jeong Song and Chan-Young Park
In general, the image analysis of nucleic acid for detecting DNA is dependent on the gel documentation system. These experiments may deal with harmful staining agents and are time consuming. To address these i...
Authors: Deuk-Ju Lee, Jong-Dae Kim, Yu-Seop Kim, Hye-Jeong Song and Chan-Young Park
The accuracy and precision of liquid handling can be altered by several causes including wearing or failure of parts, and human error. The last cause is crucial since point-of-care testing (POCT) devices can b...
Authors: Chan-Young Park, Jun Yeon, Hye-Jeong Song, Yu-Seop Kim, Ki-Bong Nahm and Jong-Dae Kim
