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  1. Infertility and subfertility affect a significant proportion of humanity. Assisted reproductive technology has been proven capable of alleviating infertility issues. In vitro fertilisation is one such option w...

    Authors: Vidas Raudonis, Agne Paulauskaite-Taraseviciene, Kristina Sutiene and Domas Jonaitis

    Citation: BioMedical Engineering OnLine 2019 18:120

    Content type: Research

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  2. Bone scaffold is one of the most effective methods to treat bone defect. The ideal scaffold of bone tissue should not only provide space for bone tissue growth, but also have sufficient mechanical strength to ...

    Authors: Su Wang, Linlin Liu, Xin Zhou, Danfeng Yang, Zhang’ao Shi and Yongqiang Hao

    Citation: BioMedical Engineering OnLine 2019 18:119

    Content type: Research

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  3. The objective of this study was to develop a strategy to optimize medical health surveillance protocols for administrative employees using video display terminals (VDTs). A total of 2453 medical examinations w...

    Authors: Saki Gerassis, Alberto Abad, Javier Taboada, Ángeles Saavedra and Eduardo Giráldez

    Citation: BioMedical Engineering OnLine 2019 18:118

    Content type: Research

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  4. One of the major concerns in implantable optoelectronics is the heat generated by emitters such as light emitting diodes (LEDs). Such devices typically produce more heat than light, whereas medical regulations...

    Authors: Fahimeh Dehkhoda, Ahmed Soltan, Nikhil Ponon, Anthony O’Neill, Andrew Jackson and Patrick Degenaar

    Citation: BioMedical Engineering OnLine 2019 18:117

    Content type: Research

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  5. This paper investigates the benefits of data filtering via complex dual wavelet transform for metal artifact reduction (MAR). The advantage of using complex dual wavelet basis for MAR was studied on simulated ...

    Authors: Defne Us, Ulla Ruotsalainen and Sampsa Pursiainen

    Citation: BioMedical Engineering OnLine 2019 18:116

    Content type: Research

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  6. The Corvis® ST tonometer is an innovative device which, by combining a classic non-contact tonometer with an ultra-fast Scheimpflug camera, provides a number of parameters allowing for the assessment of corneal b...

    Authors: Magdalena Jędzierowska, Robert Koprowski, Sławomir Wilczyński and Katarzyna Krysik

    Citation: BioMedical Engineering OnLine 2019 18:115

    Content type: Research

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  7. The surgical success of cementless implants is determined by the evolution of the biomechanical properties of the bone–implant interface (BII). One difficulty to model the biomechanical behavior of the BII com...

    Authors: Maria Letizia Raffa, Vu-Hieu Nguyen and Guillaume Haiat

    Citation: BioMedical Engineering OnLine 2019 18:114

    Content type: Research

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  8. Magnetic induction tomography (MIT) is a tomographic imaging technique, which has potential applications in security, industry, and medicine. Typically, sensors form a closed structure around the object. Howev...

    Authors: Jia Chen, Li Ke, Qiang Du, Wanni Zu and Xiaodi Ding

    Citation: BioMedical Engineering OnLine 2019 18:113

    Content type: Research

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  9. Total motile sperm count (TMSC) and curvilinear velocity (VCL) are two important parameters in preliminary semen analysis for male infertility. Traditionally, both parameters are evaluated manually by embryolo...

    Authors: Sung-Yang Wei, Hsuan-Hao Chao, Han-Ping Huang, Chang Francis Hsu, Sheng-Hsiang Li and Long Hsu

    Citation: BioMedical Engineering OnLine 2019 18:112

    Content type: Research

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  10. Head-mounted displays (HMDs) and virtual reality (VR) have been frequently used in recent years, and a user’s experience and computation efficiency could be assessed by mounting eye-trackers. However, in addit...

    Authors: Yan Wang, Guangtao Zhai, Sichao Chen, Xiongkuo Min, Zhongpai Gao and Xuefei Song

    Citation: BioMedical Engineering OnLine 2019 18:111

    Content type: Research

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  11. An intracranial aneurysm is a cerebrovascular disorder that can result in various diseases. Clinically, diagnosis of an intracranial aneurysm utilizes digital subtraction angiography (DSA) modality as gold sta...

    Authors: Haihan Duan, Yunzhi Huang, Lunxin Liu, Huming Dai, Liangyin Chen and Liangxue Zhou

    Citation: BioMedical Engineering OnLine 2019 18:110

    Content type: Research

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  12. Currently, the mainstay of treatment in patients diagnosed with major depressive disorder (MDD) requiring medical attention is second generation anti-depressants. However, about 40% of patients treated with se...

    Authors: Naaz Kapadia, Vera Zivanovic, Bastien Moineau, Jonathan Downar, Jose Zariffa and Milos R. Popovic

    Citation: BioMedical Engineering OnLine 2019 18:109

    Content type: Research

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  13. Xenogeneic bone has been widely used in a variety of clinical bone-related disease to promote bone healing and restore bone defects. However, the adverse effects of immune system limit its application in the c...

    Authors: Xiaoxia Sun, Chenghu Liu, Yanping Shi, Chunling Li, Likui Sun, Li Hou and Xin Wang

    Citation: BioMedical Engineering OnLine 2019 18:108

    Content type: Research

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  14. The interplay between sleep structure and seizure probability has previously been studied using electroencephalography (EEG). Combining sleep assessment and detection of epileptic activity in ultralong-term EE...

    Authors: Sirin W. Gangstad, Kaare B. Mikkelsen, Preben Kidmose, Yousef R. Tabar, Sigge Weisdorf, Maja H. Lauritzen, Martin C. Hemmsen, Lars K. Hansen, Troels W. Kjaer and Jonas Duun-Henriksen

    Citation: BioMedical Engineering OnLine 2019 18:106

    Content type: Research

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  15. Pulmonary lobectomy has been a well-established curative treatment method for localized lung cancer. After left upper pulmonary lobectomy, the upward displacement of remaining lower lobe causes the distortion ...

    Authors: Qingtao Gu, Shouliang Qi, Yong Yue, Jing Shen, Baihua Zhang, Wei Sun, Wei Qian, Mohammad Saidul Islam, Suvash C. Saha and Jianlin Wu

    Citation: BioMedical Engineering OnLine 2019 18:105

    Content type: Research

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  16. The activation of stretch-activated channels (SACs) in cardiac myocytes, which changes the phases of action potential repolarization, is proven to be highly efficient for the conversion of atrial fibrillation....

    Authors: Heqing Zhan, Jingtao Zhang, Anquan Jiao and Qin Wang

    Citation: BioMedical Engineering OnLine 2019 18:104

    Content type: Research

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  17. The challenges of glycaemic control in critically ill patients have been debated for 20 years. While glycaemic control shows benefits inter- and intra-patient metabolic variability results in increased hypogly...

    Authors: Vincent Uyttendaele, Jennifer L. Knopp, Shaun Davidson, Thomas Desaive, Balazs Benyo, Geoffrey M. Shaw and J. Geoffrey Chase

    Citation: BioMedical Engineering OnLine 2019 18:102

    Content type: Research

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  18. Intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) are standard physical technologies of stereotactic body radiotherapy (SBRT) that are used for patients with non-small-cell lu...

    Authors: Xue Bai, Guoping Shan, Ming Chen and Binbing Wang

    Citation: BioMedical Engineering OnLine 2019 18:101

    Content type: Research

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  19. It is crucial to frequently inspect the proper operation of non-invasive electronic blood pressure monitors in various sites to prevent accidents from inaccurate blood pressure measurements, especially for lar...

    Authors: Young Jun Hwang, Gun Ho Kim, Sung Uk Yun and Kyoung Won Nam

    Citation: BioMedical Engineering OnLine 2019 18:100

    Content type: Research

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  20. Venous thromboembolism (VTE) is a major sequela after total knee arthroplasty (TKA). We prospectively compared the differences in the perioperative plasma d-dimer and fibrinogen levels between the individuals und...

    Authors: Ka-Kit Siu, Kwan-Ting Wu, Jih-Yang Ko, Feng-Sheng Wang, Wen-Yi Chou, Ching-Jen Wang and Shu-Jui Kuo

    Citation: BioMedical Engineering OnLine 2019 18:99

    Content type: Research

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  21. Conventional risk prediction techniques may not be the most suitable approach for personalized prediction for individual patients. Therefore, individualized predictive modeling based on similar patients has em...

    Authors: Ni Wang, Yanqun Huang, Honglei Liu, Xiaolu Fei, Lan Wei, Xiangkun Zhao and Hui Chen

    Citation: BioMedical Engineering OnLine 2019 18:98

    Content type: Research

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  22. Silk fibroin hydrogel, derived from Bombyx mori cocoons, has been shown to have potential effects on wound healing due to its excellent biocompatibility and less immunogenic and biodegradable properties. Many stu...

    Authors: Sirong He, Dan Shi, Zhigang Han, Zhaoming Dong, Yajun Xie, Fengmei Zhang, WenXin Zeng and Qiying Yi

    Citation: BioMedical Engineering OnLine 2019 18:97

    Content type: Research

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  23. Considering the clinical importance of the ventricular fibrillation and that the most used therapy to reverse it has a critical side effect on the cardiac tissue, it is desirable to optimize defibrillation par...

    Authors: Priscila C. Antoneli, Jair T. Goulart, Isabella Bonilha, Daniela D. de Carvalho and Pedro X. de Oliveira

    Citation: BioMedical Engineering OnLine 2019 18:96

    Content type: Research

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  24. Improving imaging quality is a fundamental problem in ultrasound contrast agent imaging (UCAI) research. Plane wave imaging (PWI) has been deemed as a potential method for UCAI due to its’ high frame rate and ...

    Authors: Meng Dai, Shuying Li, Yuanyuan Wang, Qi Zhang and Jinhua Yu

    Citation: BioMedical Engineering OnLine 2019 18:95

    Content type: Research

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  25. Quantum noise intrinsically limits the quality of fluoroscopic images. The lower is the X-ray dose the higher is the noise. Fluoroscopy video processing can enhance image quality and allows further patient’s d...

    Authors: A. Sarno, E. Andreozzi, D. De Caro, G. Di Meo, A. G. M. Strollo, M. Cesarelli and P. Bifulco

    Citation: BioMedical Engineering OnLine 2019 18:94

    Content type: Research

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  26. As the only arterial structure of which two main arteries merged into one, the vertebro-basilar (VA-BA) system is one of the favorite sites of cerebral atherosclerotic plaques. The aim of this study was to inv...

    Authors: Guangyu Zhu, Yuan Wei, Qi Yuan, Jian Yang and Joon Hock Yeo

    Citation: BioMedical Engineering OnLine 2019 18:93

    Content type: Research

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  27. Sleep problem or disturbance often exists in pain or neurological/psychiatric diseases. However, sleep scoring is a time-consuming tedious labor. Very few studies discuss the 5-stage (wake/NREM1/NREM2/transiti...

    Authors: Ting-Ying Wei, Chung-Ping Young, Yu-Ting Liu, Jia-Hao Xu, Sheng-Fu Liang, Fu-Zen Shaw and Chin-En Kuo

    Citation: BioMedical Engineering OnLine 2019 18:92

    Content type: Research

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  28. Enhanced external counterpulsation (EECP) is an effective method for treating patients with cerebral ischemic stroke, while hemodynamics is the major contributing factor in the treatment of EECP. Different cou...

    Authors: Bao Li, Wenxin Wang, Boyan Mao, Yahui Zhang, Sihan Chen, Haisheng Yang, Haijun Niu, Jianhang Du, Xiaoling Li and Youjun Liu

    Citation: BioMedical Engineering OnLine 2019 18:91

    Content type: Research

    Published on:

  29. Stroke-related sensory and motor deficits often steal away the independent mobility and balance from stroke survivors. Often, this compels the stroke survivors to rely heavily on their non-paretic leg during w...

    Authors: Deepesh Kumar, Nirvik Sinha, Anirban Dutta and Uttama Lahiri

    Citation: BioMedical Engineering OnLine 2019 18:90

    Content type: Research

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  30. Treadmill exercise is commonly used as an alternative to over-ground walking or running. Increasing evidence indicated the kinetics of treadmill exercise is different from that of over-ground. Biomechanics of ...

    Authors: Jie Yao, Ning Guo, Yanqiu Xiao, Zhili Li, Yinghui Li, Fang Pu and Yubo Fan

    Citation: BioMedical Engineering OnLine 2019 18:89

    Content type: Research

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  31. Carotid artery geometry is important for recapitulating a pathophysiological microenvironment to study wall shear stress (WSS)-induced endothelial dysfunction in atherosclerosis. Endothelial cells (ECs) cultur...

    Authors: Ruomeng Chen, Bo Wang, Yaxiong Liu, Jiankang He, Rong Lin and Dichen Li

    Citation: BioMedical Engineering OnLine 2019 18:87

    Content type: Research

    Published on:

  32. Microelectrode arrays play an important role in prosthetic implants for neural signal recording or applying electrical pulses stimulation to target nerve system. Safety and long-term reliability are essential ...

    Authors: Hongyan Cui, Xiaobo Xie, Shengpu Xu, Leanne L. H. Chan and Yong Hu

    Citation: BioMedical Engineering OnLine 2019 18:86

    Content type: Research

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  33. Ratcheting strain is produced due to the repeated accumulation of compressive strain in cartilage and may be a precursor to osteoarthritis. The aim of this study was to investigate the ratcheting behaviors of ...

    Authors: Li-Lan Gao, Xiang-Long Lin, Dong-Dong Liu, Ling Chen, Chun-Qiu Zhang and Hong Gao

    Citation: BioMedical Engineering OnLine 2019 18:85

    Content type: Research

    Published on:

  34. Electrical impedance tomography (EIT) is a noninvasive, radiation-free, and low-cost imaging modality for monitoring the conductivity distribution inside a patient. Nowadays, time-difference EIT (tdEIT) is use...

    Authors: Lu Cao, Haoting Li, Canhua Xu, Meng Dai, Zhenyu Ji, Xuetao Shi, Xiuzhen Dong, Feng Fu and Bin Yang

    Citation: BioMedical Engineering OnLine 2019 18:84

    Content type: Research

    Published on:

  35. Electrical impedance tomography (EIT) has been used for functional lung imaging of regional air distributions during mechanical ventilation in intensive care units (ICU). From numerous clinical and animal stud...

    Authors: Geuk Young Jang, Ghazal Ayoub, Young Eun Kim, Tong In Oh, Chi Ryang Chung, Gee Young Suh and Eung Je Woo

    Citation: BioMedical Engineering OnLine 2019 18:83

    Content type: Research

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  36. The use of flow-diverters for non-saccular cerebral posterior circulation aneurysms requires complex deployment techniques and is associated with high mortality and morbidity. Therefore, further studies are re...

    Authors: Sergey Sindeev, Jan Stephan Kirschke, Sascha Prothmann, Sergey Frolov, Dieter Liepsch, Philipp Berg, Claus Zimmer and Benjamin Friedrich

    Citation: BioMedical Engineering OnLine 2019 18:82

    Content type: Research

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  37. The future of biomedical engineering is exciting, and prospects for biomedical engineering journals are rapidly growing. In this editorial, a brief history of Biomedical Engineering Online is outlined, along with...

    Authors: Ervin Sejdić and Fong-Chin Su

    Citation: BioMedical Engineering OnLine 2019 18:81

    Content type: Editorial

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  38. It was highlighted that the original article [1] had an omission in the Abstract. This Correction article shows the omitted sentence: “This article [1] was awarded the SIAMOC Best Methodological Paper 2018”.

    Authors: Ilaria Arcolin, Stefano Corna, Marica Giardini, Andrea Giordano, Antonio Nardone and Marco Godi

    Citation: BioMedical Engineering OnLine 2019 18:80

    Content type: Correction

    Published on:

    The original article was published in BioMedical Engineering OnLine 2019 18:70

  39. Deep brain stimulation (DBS) has a good prospect for treating many brain diseases. Recent studies have shown that axonal activation induced by pulse stimulations may play an important role in DBS therapies thr...

    Authors: Chen Qiu, Zhouyan Feng, Lvpiao Zheng and Weijian Ma

    Citation: BioMedical Engineering OnLine 2019 18:79

    Content type: Research

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  40. Hemodialysis mainly relies on the “artificial kidney,” which plays a very important role in temporarily or permanently substituting for the kidney to carry out the exchange of waste and discharge of water. Nev...

    Authors: An-Jin Shie, Kuei-Hsing Lo, Wen-Tsann Lin, Chi-Wen Juan and Yung-Tsan Jou

    Citation: BioMedical Engineering OnLine 2019 18:78

    Content type: Research

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  41. Temperature monitoring during high-intensity focused ultrasound (HIFU) therapy on tissue is essential to regulate the degree of thermal coagulation and to achieve the desired treatment outcomes eventually. The...

    Authors: Suhyun Park, Ngot Thi Pham, Huu-Toan Huynh and Hyun Wook Kang

    Citation: BioMedical Engineering OnLine 2019 18:77

    Content type: Research

    Published on:

  42. Several countries encourage the practice of football for rehabilitation and social inclusion purposes. For visually impaired people, football is purely sound-based, where the ball and the players are constantl...

    Authors: Francisco Yandun, Fernando A. Auat Cheein, Daniela Lorca, Omar Acevedo and Cecilia Auat Cheein

    Citation: BioMedical Engineering OnLine 2019 18:76

    Content type: Research

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  43. Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general ...

    Authors: René van Es, Maurits K. Konings, Bastiaan C. Du Pré, Kars Neven, Harry van Wessel, Vincent J. H. M. van Driel, Albert H. Westra, Pieter A. F. Doevendans and Fred H. M. Wittkampf

    Citation: BioMedical Engineering OnLine 2019 18:75

    Content type: Research

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  44. Human brain models and pharmacological models of brain diseases are in high demand for drug screening because animal models have been found to be less than ideal for fully representing the human brain and are ...

    Authors: Ao Fang, Dichen Li, Zhiyan Hao, Ling Wang, Binglei Pan, Lin Gao, Xiaoli Qu and Jiankang He

    Citation: BioMedical Engineering OnLine 2019 18:74

    Content type: Research

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    The Correction to this article has been published in BioMedical Engineering OnLine 2019 18:88

  45. Patients with end-stage heart failure must receive treatment to recover cardiac function, and the current primary therapy, heart transplantation, is plagued by the limited supply of donor hearts. Bioengineered...

    Authors: Cailing Tong, Cheng Li, Baiyi Xie, Minghui Li, Xianguo Li, Zhongquan Qi and Junjie Xia

    Citation: BioMedical Engineering OnLine 2019 18:71

    Content type: Research

    Published on: