Articles

The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019

Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation of the epidemiological c...

Authors: Yiyi Yao, Xiangjie Lin, Fenglin Li, Jie Jin and Huafeng Wang

Functionalization of screw implants with superelastic structured Nitinol anchoring elements

Demographic change is leading to an increase in the number of osteoporotic patients, so a rethink is required in implantology in order to be able to guarantee adequate anchoring stability in the bone. The func...

Authors: Isabell Hamann, Stefan Schleifenbaum, Christian Rotsch, Welf-Guntram Drossel, Christoph-Eckhard Heyde and Mario Leimert

Detection and analysis of long noncoding RNA expression profiles related to epithelial–mesenchymal transition in keloids

The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long noncoding RNAs (lncRNAs) govern a variety of biological processes, such as EMT...

Authors: Zhixiong Chen, Xi Chu and Jinghong Xu

Development of a bowel sound detector adapted to demonstrate the effect of food intake

Bowel sounds (BS) carry useful information about gastrointestinal condition and feeding status. Interest in computerized bowel sound-based analysis has grown recently and techniques have evolved rapidly. An im...

Authors: Ning Wang, Alison Testa and Barry J. Marshall

Evaluating effect of metallic ions on aggregation behavior of β-amyloid peptides by atomic force microscope and surface-enhanced Raman Scattering

Excessive aggregation of β-amyloid peptides (Aβ) is regarded as the hallmark of Alzheimer’s disease. Exploring the underlying mechanism regulating Aβ aggregation remains challenging and investigating aggregati...

Authors: Yang Xie, Lin Yu, Yuna Fu, Heng Sun and Jianhua Wang

Brain CT registration using hybrid supervised convolutional neural network

Image registration is an essential step in the automated interpretation of the brain computed tomography (CT) images of patients with acute cerebrovascular disease (ACVD). However, performing brain CT registra...

Authors: Hongmei Yuan, Minglei Yang, Shan Qian, Wenxin Wang, Xiaotian Jia and Feng Huang

Quantitative evaluation of ankle cartilage in asymptomatic adolescent football players after season by T2-mapping magnetic resonance imaging

Ankle sprain affects the structure and function of ankle cartilage. However, it is not clear whether the daily training and competition affect the ankle cartilage without acute injury. Changes in ankle cartila...

Authors: Sipin Luo, Yi Cao, Peng Hu, Nan Wang and Yeda Wan

Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma

Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRN...

Authors: Shumin Xie, Li Jin, Tuanfang Yin, Jihao Ren and Wei Liu

Correction to: Study on the methodology of striae gravidarum severity evaluation

Authors: Hongyan Dai, Yangyang Liu, Yan Zhu, Yun Yu and Lin Meng

LRSCnet: Local Reference Semantic Code learning for breast tumor classification in ultrasound images

This study proposed a novel Local Reference Semantic Code (LRSC) network for automatic breast ultrasound image classification with few labeled data.

Authors: Guang Zhang, Yanwei Ren, Xiaoming Xi, Delin Li, Jie Guo, Xiaofeng Li, Cuihuan Tian and Zunyi Xu

Design of bionic active–passive hybrid-driven prosthesis based on gait analysis and simulation of compound control method

The purpose of this paper is to design a prosthetic limb that is close to the motion characteristics of the normal human ankle joint.

Authors: Xinsheng Xu, Xiaoli Xu, Ying Liu, Kai Zhong and Haowei Zhang

Protective effects of wogonin on lipopolysaccharide-induced inflammation and apoptosis of lung epithelial cells and its possible mechanisms

Wogonin (5, 7-dihydroxy-8-methoxyflavone) is a natural di-hydroxyl flavonoid extracted from the root of Scutellaria baicalensis Georgi. This paper was intended to investigate the mechanism of action of wogonin in...

Authors: Jinlin Ge, Huanhuan Yang, Yufeng Zeng and Yunjie Liu

Public transcriptome database-based selection and validation of reliable reference genes for breast cancer research

Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) is the most sensitive technique for evaluating gene expression levels. Choosing appropriate reference genes (RGs) is critical for normaliz...

Authors: Qiang Song, Lu Dou, Wenjin Zhang, Yang Peng, Man Huang and Mengyuan Wang

Pulmonary lesion subtypes recognition of COVID-19 from radiomics data with three-dimensional texture characterization in computed tomography images

The COVID-19 disease is putting unprecedented pressure on the global healthcare system. The CT (computed tomography) examination as a auxiliary confirmed diagnostic method can help clinicians quickly detect le...

Authors: Wei Li, Yangyong Cao, Kun Yu, Yibo Cai, Feng Huang, Minglei Yang and Weidong Xie

Camera-based heart rate estimation for hospitalized newborns in the presence of motion artifacts

Heart rate (HR) is an important vital sign for evaluating the physiological condition of a newborn infant. Recently, for measuring HR, novel RGB camera-based non-contact techniques have demonstrated their specifi...

Authors: Qiong Chen, Yalin Wang, Xiangyu Liu, Xi Long, Bin Yin, Chen Chen and Wei Chen

Dysregulation of alternative splicing is associated with the pathogenesis of ulcerative colitis

Although numerous risk loci for ulcerative colitis (UC) have been identified in the human genome, the pathogenesis of UC remains unclear. Recently, multiple transcriptomic analyses have shown that aberrant gen...

Authors: Daowei Li and Yue Tan

Automated landmarking of bends in vascular structures: a comparative study with application to the internal carotid artery

Automated tools for landmarking the internal carotid artery (ICA) bends have the potential for efficient and objective medical image-based morphometric analysis. The two existing algorithms rely on numerical a...

Authors: Henrik A Kjeldsberg, Aslak W Bergersen and Kristian Valen-Sendstad

Effect of limb rotation on radiographic alignment measurement in mal-aligned knees

Long-leg-radiography (LLR) is commonly used for the measurement of lower limb alignment. However, limb rotations during radiography may interfere with the alignment measurement. This study examines the effect ...

Authors: Xiaoshu Sun, Bin Yang, Shengzhao Xiao, Yichen Yan, Zifan Liu, Liang Yuan, Xiaohua Wang, Bin Sun, Jie Yao and Yubo Fan

Long-term training on sand changes lower limb muscle activities during running in runners with over-pronated feet

Running on sand could be a promising exercise intervention for the treatment of over-pronated feet. However, there is a lack of knowledge about the effects of running on sand on muscle activities. Therefore, t...

Authors: AmirAli Jafarnezhadgero, Amir Fatollahi, Ali Sheykholeslami, Valdeci Carlos Dionisio and Mohammad Akrami

Identification of a novel prognosis-associated ceRNA network in lung adenocarcinoma via bioinformatics analysis

Lung adenocarcinoma (LUAD) is the most common subtype of nonsmall-cell lung cancer (NSCLC) and has a high incidence rate and mortality. The survival of LUAD patients has increased with the development of targe...

Authors: Yumiao Li, Xiaoxue Yu, Yuhao Zhang, Xiaofang Wang, Linshan Zhao, Dan Liu, Guofa Zhao, Xiangpeng Gao, Jiejun Fu, Aimin Zang and Youchao Jia

Characterization and in vitro assessment of three-dimensional extrusion Mg-Sr codoped SiO₂-complexed porous microhydroxyapatite whisker scaffolds for biomedical engineering

Large bone defects have always been a great challenge for orthopedic surgeons. The use of a good bone substitute obtained by bone tissue engineering (BTE) may be an effective treatment method. Artificial hydro...

Authors: Chengyong Li, Tingting Yan, Zhenkai Lou, Zhimin Jiang, Zhi Shi, Qinghua Chen, Zhiqiang Gong and Bing Wang

Effects of gold nanoparticles combined with human β-defensin 3 on the alveolar bone loss of periodontitis in rat

Nanomaterials of biomedicine and tissue engineering have been proposed for the treatment of periodontitis in recent years. This study aimed to investigate the effects of gold nanoparticles (AuNPs) combined wit...

Authors: Jing Zhou, Lingjun Li, Di Cui, Xiaoting Xie, Wenrong Yang and Fuhua Yan

A mobile-assisted voice condition analysis system for Parkinson’s disease: assessment of usability conditions

Automatic voice condition analysis systems to detect Parkinson’s disease (PD) are generally based on speech data recorded under acoustically controlled conditions and professional supervision. The performance ...

Authors: Javier Carrón, Yolanda Campos-Roca, Mario Madruga and Carlos J. Pérez

Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue

The corneal biomechanical properties with the prolongation of time after corneal refractive surgery are important for providing a mechanical basis for the occurrence of clinical phenomena such as iatrogenic ke...

Authors: Di Zhang, Xiao Qin, Haixia Zhang and Lin Li

Fus2Net: a novel Convolutional Neural Network for classification of benign and malignant breast tumor in ultrasound images

The rapid development of artificial intelligence technology has improved the capability of automatic breast cancer diagnosis, compared to traditional machine learning methods. Convolutional Neural Network (CNN...

Authors: He Ma, Ronghui Tian, Hong Li, Hang Sun, Guoxiu Lu, Ruibo Liu and Zhiguo Wang

Moderate-intensity treadmill running relieves motion-induced post-traumatic osteoarthritis mice by up-regulating the expression of lncRNA H19

The purpose of this study was to explore whether moderate-intensity exercise can alleviate motion-induced post-traumatic osteoarthritis (PTOA) and the expression change of lncRNA H19 during this progression.

Authors: Xuchang Zhou, Hong Cao, Miao Wang, Jun Zou and Wei Wu

Temperature-dependent tensile properties of polyamide 12 for the use in percutaneous transluminal coronary angioplasty balloon catheters

Percutaneous transluminal coronary angioplasty (PTCA) balloon catheters must withstand high pressures required for the lesion treatment, pushing loads during insertion, and pulling loads during withdrawal. The...

Authors: C. Amstutz, B. Weisse, S. Valet, A. Haeberlin, J. Burger and A. Zurbuchen

Study on the methodology of striae gravidarum severity evaluation

Striae gravidarum is a common occurrence in pregnancy and many women expect to prevent its development. At present, laser treatment has been used to improve the appearance of striae gravidarum, but the choice ...

Authors: Hongyan Dai, Yangyang Liu, Yan Zhu, Yun Yu and Lin Meng

Instantaneous radiated power of brain activity: application to prepulse inhibition and facilitation for body dysmorphic disorder

Global measures of neuronal activity embrace the advantage of a univariate, holistic and unique description of brain activity, reducing the spatial dimensions of electroencephalography (EEG) analysis at the co...

Authors: Anastasios E. Giannopoulos, Sotirios T. Spantideas, Christos Capsalis, Panos Papageorgiou, Nikolaos Kapsalis, Konstantinos Kontoangelos and Charalabos Papageorgiou

Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes

Psoriasis is a common chronic recurrent inflammatory skin disease. The pathogenesis of psoriasis, such as other autoimmune diseases, is still unclear, which brings great difficulties to the treatment. This stu...

Authors: Xiaohui Sun and Pengfei Yang

Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy

Image-guided adaptive brachytherapy shows the ability to deliver high doses to tumors while sparing normal tissues. However, interfraction dose delivery introduces uncertainties to high dose estimation, which ...

Authors: Binbing Wang, Weibiao Hu, Guoping Shan and Xiaoxian Xu

Intraoperative serosal extracellular mapping of the human distal colon: a feasibility study

Cyclic motor patterns (CMP) are the predominant motor pattern in the distal colon, and are important in both health and disease. Their origin, mechanism and relation to bioelectrical slow-waves remain incomple...

Authors: Anthony Y. Lin, Chris Varghese, Peng Du, Cameron I. Wells, Niranchan Paskaranandavadivel, Armen A. Gharibans, Jonathan C. Erickson, Ian P. Bissett and Greg O’Grady

Outdoor walking exhibits peak ankle and knee flexion differences compared to fixed and adaptive-speed treadmills in older adults

Walking mechanics recorded with a traditional treadmill may not be the same as the mechanics exhibited during activities of daily living due to constrained walking speeds. Adaptive-speed treadmills allow for u...

Authors: Sheridan M. Parker, Jeremy Crenshaw, Nathaniel H. Hunt, Christopher Burcal and Brian A. Knarr

Bugan Rongjin decoction alleviates inflammation and oxidative stress to treat the postmenopausal knee osteoarthritis through Wnt signaling pathway

Traditional Chinese medicine has been found effective for the therapy of knee osteoarthritis (KOA). This study was aimed at investigating the underlying mechanism of Bugan Rongjin decoction (BGRJ) in treating ...

Authors: Sheng Wang, Pei Ding, Xiaopeng Xia, Xuexian Chen, Daguo Mi, Shuijie Sheng, Fulong Gu, Zhongwei Li, Kelei Su and Yuwei Li

New epiretinal implant with integrated sensor chips for optical capturing shows a good biocompatibility profile in vitro and in vivo

Retinal degenerative diseases, e.g., retinitis pigmentosa, cause a severe decline of the visual function up to blindness. Treatment still remains difficult; however, implantation of retinal prostheses can help...

Authors: Kim Schaffrath, Tibor Lohmann, Jan Seifert, Claudia Ingensiep, Pascal Raffelberg, Florian Waschkowski, Reinhard Viga, Rainer Kokozinski, Wilfried Mokwa, Sandra Johnen and Peter Walter

Sharp loss: a new loss function for radiotherapy dose prediction based on fully convolutional networks

Neural-network methods have been widely used for the prediction of dose distributions in radiotherapy. However, the prediction accuracy of existing methods may be degraded by the problem of dose imbalance. In ...

Authors: Xue Bai, Jie Zhang, Binbing Wang, Shengye Wang, Yida Xiang and Qing Hou

Multiple overlapping stent-assisted coiling improves efficacy and safety of treatment for complex intracranial aneurysms: a randomized trial

Intracranial aneurysm rupture is the main cause of subarachnoid hemorrhage, leading to high disability and mortality. This study aimed to evaluate the clinical treatment effects of multiple overlapping stent-a...

Authors: Lingtong You, Jiaxin Huang, Jinning Zhang and Zhixian Jiang

Effects of lead exposure on blood electrical impedance spectroscopy of mice

Lead is a nonessential heavy metal, which can inhibit heme synthesis and has significant cytotoxic effects. Nevertheless, its effect on the electrical properties of red blood cells (RBCs) remains unclear. Cons...

Authors: Binying Yang, Jia Xu, Shao Hu, Boning You and Qing Ma

Influence of posterior pedicle screw fixation at L4–L5 level on biomechanics of the lumbar spine with and without fusion: a finite element method

Posterior pedicle screw (PS) fixation, a common treatment method for widespread low-back pain problems, has many uncertain aspects including stress concentration levels, effects on adjacent segments, and relat...

Authors: Emre Sengul, Ramazan Ozmen, Mesut Emre Yaman and Teyfik Demir

Changes in retinal multilayer thickness and vascular network of patients with Alzheimer’s disease

Retinal biomarkers of Alzheimer’s disease (AD) have been extensively investigated in recent decades. Retinal nervous and vascular parameters can reflect brain conditions, and they can facilitate early diagnosi...

Authors: Xi Mei, Conglong Qiu, Qi Zhou, Zhongming Chen, Yang Chen, Zemin Xu and Chenjun Zou

Structural geometries and mechanical properties of vertebral implant with honeycomb sandwich structure for vertebral compression fractures: a finite element analysis

Because of osteoporosis, traffic accidents, falling from high places, and other reasons, the vertebral body can be compressed and even collapse. Vertebral implants can be used for clinical treatment. Because o...

Authors: Yuan Guo, Jing Liu, Xushu Zhang, Zejun Xing, Weiyi Chen and Di Huang

Effect of guidewire insertion in fractional flow reserve procedure for real geometry using computational fluid dynamics

Coronary artery disease is an abnormal contraction of the heart supply blood vessel. It limits the oxygenated blood flow to the heart. Thus, diagnosing its severity helps physicians to select the appropriate t...

Authors: Yasser Abuouf, Muhamed AlBadawi, Shinichi Ookawara and Mahmoud Ahmed

A 2D–3D hybrid convolutional neural network for lung lobe auto-segmentation on standard slice thickness computed tomography of patients receiving radiotherapy

Accurate segmentation of lung lobe on routine computed tomography (CT) images of locally advanced stage lung cancer patients undergoing radiotherapy can help radiation oncologists to implement lobar-level trea...

Authors: Hengle Gu, Wutian Gan, Chenchen Zhang, Aihui Feng, Hao Wang, Ying Huang, Hua Chen, Yan Shao, Yanhua Duan and Zhiyong Xu

Extended classifier system with continuous real-coded variables for feature extraction of instantaneous pulse-rate variability and respiration of individuals with gaming disorder

Individuals with gaming disorder (GD) exhibit autonomic nervous system responses that indicate dysfunctional emotion regulation. Pulse rate variability (PRV) is a valuable biomarker for investigating the auton...

Authors: Hung-Ming Chi and Tzu-Chien Hsiao

Beam orientation optimization for coherent X-ray scattering from distributed deep targets

Amyloid deposits in the temporal and frontal lobes in patients with Alzheimer’s disease make them potential targets to aid in early diagnosis. Recently, spectral small-angle X-ray scattering techniques have be...

Authors: Sophya Breedlove and Aldo Badano

Effects of sub-atmospheric pressure and dissolved oxygen concentration on lesions generated in ex vivo tissues by high intensity focused ultrasound

Acoustic cavitation plays an important role in the medical treatment using high-intensity focused ultrasound (HIFU), but unnecessarily strong cavitation also could deform the morphology and enlarge the size of...

Authors: Min He, Zhiqiang Zhong, Deping Zeng, Xiaobo Gong, Zhibiao Wang and Faqi Li

Gait training with a wearable curara® robot for cerebellar ataxia: a single-arm study

Ataxic gait is one of the most common and disabling symptoms in people with degenerative cerebellar ataxia. Intensive and well-coordinated inpatient rehabilitation improves ataxic gait. In addition to therapis...

Authors: Akira Matsushima, Yoichi Maruyama, Noriaki Mizukami, Mikio Tetsuya, Minoru Hashimoto and Kunihiro Yoshida

Robotic devices for paediatric rehabilitation: a review of design features

Children with physical disabilities often have limited performance in daily activities, hindering their physical development, social development and mental health. Therefore, rehabilitation is essential to mit...

Authors: Alberto Gonzalez, Lorenzo Garcia, Jeff Kilby and Peter McNair

Hypoxia-inducible transcription factor-1α inhibition by topotecan protects against lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes

Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role of hy...

Authors: Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Meng Yan and Jun Xiao

Prediction of exercise sudden death in rabbit exhaustive swimming using deep neural network

Moderate exercise contributes to good health. However, excessive exercise may lead to cardiac fatigue, myocardial damage and even exercise sudden death. Monitoring the heart health has important implication to...

Authors: Yao Zhang, Yineng Zheng, Menglu Wang and Xingming Guo