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  1. To reproduce anatomical reduction and appropriate implant placement/choices during osteosynthesis for elbow fractures, we developed a 3D preoperative planning system. To assess the utility of 3D digital preope...

    Authors: Yuichi Yoshii, Shin Teramura, Kazuki Oyama, Takeshi Ogawa, Yuki Hara and Tomoo Ishii

    Citation: BioMedical Engineering OnLine 2020 19:56

    Content type: Research

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  2. Three-dimensional (3D) printing is a promising technology, but the limitations are often poorly understood. We compare different 3D printing methods with conventional machining techniques in manufacturing meat...

    Authors: Michael Y. Chen, Jacob Skewes, Ryan Daley, Maria A. Woodruff and Nicholas J. Rukin

    Citation: BioMedical Engineering OnLine 2020 19:55

    Content type: Research

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  3. The objective of the study is to investigate the effect of catheter type and injection method on microsphere distributions, specifically vessel targeting accuracy.

    Authors: Shaphan R. Jernigan, Jason A. Osborne and Gregory D. Buckner

    Citation: BioMedical Engineering OnLine 2020 19:54

    Content type: Research

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  4. Anorexia nervosa is a clinical disorder syndrome of the wide spectrum without a fully recognized etiology. The necessary issue in the clinical diagnostic process is to detect the causes of this disease (e.g., ...

    Authors: Dominik Spinczyk, Mateusz Bas, Mariusz Dzieciątko, Michał Maćkowski, Katarzyna Rojewska and Stella Maćkowska

    Citation: BioMedical Engineering OnLine 2020 19:53

    Content type: Research

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  5. Colorectal cancer is the third leading cause of cancer-related deaths worldwide. Sonodynamic therapy (SDT) is an emerging cancer therapy, and in contrast to photodynamic therapy, could non-invasively reach dee...

    Authors: Yuanyuan Shen, Jianquan Ou, Xin Chen, Xiaojun Zeng, Lanhui Huang, Zhaoke Pi, Yaxin Hu, Siping Chen and Tie Chen

    Citation: BioMedical Engineering OnLine 2020 19:52

    Content type: Research

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  6. Image segmentation is an important part of computer-aided diagnosis (CAD), the segmentation of small ground glass opacity (GGO) pulmonary nodules is beneficial for the early detection of lung cancer. For the s...

    Authors: Shaorong Zhang, Xiangmeng Chen, Zhibin Zhu, Bao Feng, Yehang Chen and Wansheng Long

    Citation: BioMedical Engineering OnLine 2020 19:51

    Content type: Research

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  7. Advances in transcranial electrical stimulation (tES) are hampered by the conventional rubber electrodes manually attached to the head with rubber bands. This procedure limits montages to a few electrodes, is ...

    Authors: Alexander Hunold, Daniela Ortega, Klaus Schellhorn and Jens Haueisen

    Citation: BioMedical Engineering OnLine 2020 19:50

    Content type: Research

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  8. Heartbeat interval Lorenz plot (LP) imaging is a promising method for detecting atrial fibrillation (AF) in long-term monitoring, but the optimal segment window length for the LP images is unknown. We examined...

    Authors: Masaya Kisohara, Yuto Masuda, Emi Yuda, Norihiro Ueda and Junichiro Hayano

    Citation: BioMedical Engineering OnLine 2020 19:49

    Content type: Research

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  9. The development of wearable health monitoring systems is garnering tremendous interest in research, technology and commercial applications. Their ability of providing unique capabilities in continuous, real-ti...

    Authors: Milad Alizadeh Meghrazi, Yupeng Tian, Amin Mahnam, Presish Bhattachan, Ladan Eskandarian, Sara Taghizadeh Kakhki, Milos R. Popovic and Milad Lankarany

    Citation: BioMedical Engineering OnLine 2020 19:48

    Content type: Research

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  10. The safe and accurate placement of pedicle screws remains a critical step in open and minimally invasive spine surgery, emphasizing the need for intraoperative guidance techniques. Diffuse reflectance spectros...

    Authors: Akash Swamy, Jarich W. Spliethoff, Gustav Burström, Drazenko Babic, Christian Reich, Joanneke Groen, Erik Edström, Adrian Elmi-Terander, John M. Racadio, Jenny Dankelman and Benno H. W. Hendriks

    Citation: BioMedical Engineering OnLine 2020 19:47

    Content type: Research

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  11. Neurofeedback aids volitional control of one’s own brain activity using non-invasive recordings of brain activity. The applications of neurofeedback include improvement of cognitive performance and treatment o...

    Authors: Kunjan D. Rana, Sheraz Khan, Matti S. Hämäläinen and Lucia M. Vaina

    Citation: BioMedical Engineering OnLine 2020 19:45

    Content type: Research

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  12. Restenosis remains a challenge in the treatment of atherosclerosis due to damage to the endothelial layer and induced proliferation of smooth muscle cells. A novel radiofrequency (RF) heating strategy was prop...

    Authors: Shiqing Zhao, Jincheng Zou, Hongying Wang, Jinbao Qin, Xinwu Lu, Aili Zhang and Lisa X. Xu

    Citation: BioMedical Engineering OnLine 2020 19:44

    Content type: Research

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wei Hou, Xianting Zhu, Juan Liu and Jiaguo Ma

    Citation: BioMedical Engineering OnLine 2020 19:43

    Content type: Correction

    Published on:

    The original article was published in BioMedical Engineering OnLine 2020 19:15

  14. Diffusion MRI is the preferred non-invasive in vivo modality for the study of brain white matter connections. Tractography datasets contain 3D streamlines that can be analyzed to study the main brain white mat...

    Authors: Andrea Vázquez, Narciso López-López, Josselin Houenou, Cyril Poupon, Jean-François Mangin, Susana Ladra and Pamela Guevara

    Citation: BioMedical Engineering OnLine 2020 19:42

    Content type: Research

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  15. Skull stripping remains a challenge for neonatal brain MR image analysis. However, little is known about the accuracy of how skull stripping affects the neonatal brain tissue segmentation and subsequent networ...

    Authors: Geliang Wang, Yajie Hu, Xianjun Li, Miaomiao Wang, Congcong Liu, Jian Yang and Chao Jin

    Citation: BioMedical Engineering OnLine 2020 19:41

    Content type: Research

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  16. Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood....

    Authors: Hongyun Liu, Ping Zhan, Fangang Meng and Weidong Wang

    Citation: BioMedical Engineering OnLine 2020 19:40

    Content type: Research

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  17. Radiotherapy treatment planning dose prediction can be used to ensure plan quality and guide automatic plan. One of the dose prediction methods is incorporating historical treatment planning data into algorith...

    Authors: Xue Bai, Binbing Wang, Shengye Wang, Zhangwen Wu, Chengjun Gou and Qing Hou

    Citation: BioMedical Engineering OnLine 2020 19:39

    Content type: Research

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  18. As the rupture of cerebral aneurysm may lead to fatal results, early detection of unruptured aneurysms may save lives. At present, the contrast-unenhanced time-of-flight magnetic resonance angiography is one o...

    Authors: Geng Chen, Xia Wei, Huang Lei, Yang Liqin, Li Yuxin, Dai Yakang and Geng Daoying

    Citation: BioMedical Engineering OnLine 2020 19:38

    Content type: Research

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  19. Vessel diseases are often accompanied by abnormalities related to vascular shape and size. Therefore, a clear visualization of vasculature is of high clinical significance. Ultrasound color flow imaging (CFI) ...

    Authors: Naiyuan Zhang, Md Ashikuzzaman and Hassan Rivaz

    Citation: BioMedical Engineering OnLine 2020 19:37

    Content type: Review

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  20. Pharyngeal fricative is one typical compensatory articulation error of cleft palate speech. It passively influences daily communication for people who suffer from it. The automatic detection of pharyngeal fric...

    Authors: Fei He, Xiyue Wang, Heng Yin, Han Zhang, Gang Yang and Ling He

    Citation: BioMedical Engineering OnLine 2020 19:36

    Content type: Research

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  21. Electrical conductivity of a biological tissue at low frequencies can be approximately expressed as a tensor. Noting that cross-sectional imaging of a low-frequency conductivity tensor distribution inside the ...

    Authors: Bup Kyung Choi, Nitish Katoch, Hyung Joong Kim, Ji Ae Park, In Ok Ko, Oh In Kwon and Eung Je Woo

    Citation: BioMedical Engineering OnLine 2020 19:35

    Content type: Research

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  22. Functional electrical stimulation is a technique to produce functional movements after paralysis. Electrical discharges are applied to a person’s muscles making them contract in a sequence that allows performi...

    Authors: Cesar Marquez-Chin and Milos R. Popovic

    Citation: BioMedical Engineering OnLine 2020 19:34

    Content type: Review

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  23. In the past years, robotic systems have become increasingly popular in upper limb rehabilitation. Nevertheless, clinical studies have so far not been able to confirm superior efficacy of robotic therapy over c...

    Authors: Christian Giang, Elvira Pirondini, Nawal Kinany, Camilla Pierella, Alessandro Panarese, Martina Coscia, Jenifer Miehlbradt, Cécile Magnin, Pierre Nicolo, Adrian Guggisberg and Silvestro Micera

    Citation: BioMedical Engineering OnLine 2020 19:33

    Content type: Research

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  24. Lung mechanics measurements provide clinically useful information about disease progression and lung health. Currently, there are no commonly practiced methods to non-invasively measure both resistive and elas...

    Authors: Sarah L. Howe, Melanie März, Sabine Krüger-Ziolek, Bernhard Laufer, Chris Pretty, Geoffery M. Shaw, Thomas Desaive, Knut Möller and J. Geoffrey Chase

    Citation: BioMedical Engineering OnLine 2020 19:32

    Content type: Research

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  25. Coarctation of the aorta is a common form of critical congenital heart disease that remains challenging to diagnose prior to clinical deterioration. Despite current screening methods, infants with coarctation ...

    Authors: Matthew W. Sorensen, Ismail Sadiq, Gari D. Clifford, Kevin O. Maher and Matthew E. Oster

    Citation: BioMedical Engineering OnLine 2020 19:31

    Content type: Research

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  26. With the development of wearable health-monitoring technologies, a variety of textile electrodes have been produced and applied by researchers. However, there are no universal and effective methods even testin...

    Authors: Jinzhong Song, Yu Zhang, Yijing Yang, Hao Liu, Tianshu Zhou, Kui Zhang, Fan Li, Zhi Xu, Qingjun Liu and Jingsong Li

    Citation: BioMedical Engineering OnLine 2020 19:30

    Content type: Research

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  27. Balance training improves postural control in Parkinson’s disease (PD). However, a systematic approach for the development of individualized, optimal training programs is still lacking, as the learning dynamic...

    Authors: Zahra Rahmati, Saeed Behzadipour, Alfred C. Schouten, Ghorban Taghizadeh and Keikhosrow Firoozbakhsh

    Citation: BioMedical Engineering OnLine 2020 19:29

    Content type: Research

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  28. Our group developed a rehabilitation robot to assist with repetitive, active reaching movement of a paretic upper extremity. The robot is equipped with a servo motor-controlled arm-weight support and works in ...

    Authors: Yumeko Amano, Tomokazu Noma, Seiji Etoh, Ryuji Miyata, Kentaro Kawamura and Megumi Shimodozono

    Citation: BioMedical Engineering OnLine 2020 19:28

    Content type: Research

    Published on:

  29. Catheter ablation therapy involving isolation of pulmonary veins (PVs) from the left atrium is performed to terminate atrial fibrillation (AF). Unfortunately, standalone PV isolation procedure has shown to be ...

    Authors: Prasanth Ganesan, Elizabeth M. Cherry, David T. Huang, Arkady M. Pertsov and Behnaz Ghoraani

    Citation: BioMedical Engineering OnLine 2020 19:27

    Content type: Research

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  30. STAR is a model-based, personalised, risk-based dosing approach for glycaemic control (GC) in critically ill patients. STAR provides safe, effective control to nearly all patients, using 1–3 hourly measurement...

    Authors: Vincent Uyttendaele, Jennifer L. Knopp, Geoffrey M. Shaw, Thomas Desaive and J. Geoffrey Chase

    Citation: BioMedical Engineering OnLine 2020 19:26

    Content type: Research

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  31. Emerging sensing and communication technologies are contributing to the development of many motor rehabilitation programs outside the standard healthcare facilities. Nowadays, motor rehabilitation exercises ca...

    Authors: Bojan Milosevic, Alberto Leardini and Elisabetta Farella

    Citation: BioMedical Engineering OnLine 2020 19:25

    Content type: Research

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  32. Trigger finger is a common hand disease, which is caused by a mismatch in diameter between the tendon and the pulley. Ultrasound images are typically used to diagnose this disease, which are also used to guide...

    Authors: Chan-Pang Kuok, Tai-Hua Yang, Bo-Siang Tsai, I-Ming Jou, Ming-Huwi Horng, Fong-Chin Su and Yung-Nien Sun

    Citation: BioMedical Engineering OnLine 2020 19:24

    Content type: Research

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  33. Temporomandibular disorders (TMDs) are pathological conditions affecting the temporomandibular joint and/or masticatory muscles. The current diagnosis of TMDs is complex and multi-factorial, including question...

    Authors: Bruno Coelho Calil, Danilo Vieira da Cunha, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Daniel Antônio Furtado, Douglas Peres Bellomo Junior and Adriano Alves Pereira

    Citation: BioMedical Engineering OnLine 2020 19:22

    Content type: Research

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  34. As one of the major complications of diabetes, diabetic retinopathy (DR) is a leading cause of visual impairment and blindness due to delayed diagnosis and intervention. Microaneurysms appear as the earliest s...

    Authors: Shengchun Long, Jiali Chen, Ante Hu, Haipeng Liu, Zhiqing Chen and Dingchang Zheng

    Citation: BioMedical Engineering OnLine 2020 19:21

    Content type: Research

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  35. This is a systematic review on the main algorithms using machine learning (ML) in retinal image processing for glaucoma diagnosis and detection. ML has proven to be a significant tool for the development of co...

    Authors: Daniele M. S. Barros, Julio C. C. Moura, Cefas R. Freire, Alexandre C. Taleb, Ricardo A. M. Valentim and Philippi S. G. Morais

    Citation: BioMedical Engineering OnLine 2020 19:20

    Content type: Review

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  36. The His–Purkinje (HP) system provides a pathway for the time-synchronous contraction of the heart. His bundle (HB) of the HP system is gaining relevance as a pacing site for treating non-reversible bradyarrhyt...

    Authors: Ankur R. Shah, Muhammad S. Khan, Annie M. Hirahara, Matthias Lange, Ravi Ranjan and Derek J. Dosdall

    Citation: BioMedical Engineering OnLine 2020 19:19

    Content type: Research

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  37. The remineralization approach mechanically occludes the exposed dentinal tubules mechanically, reduces the permeability of dentinal tubules and eliminates the symptoms of dentin hypersensitivity. The aim of th...

    Authors: Zhou Zhou, Xingyun Ge, Minxia Bian, Tao Xu, Na Li, Jiamin Lu and Jinhua Yu

    Citation: BioMedical Engineering OnLine 2020 19:18

    Content type: Research

    Published on:

  38. Distraction osteogenesis (DO) is an emerging method for bone tissue reconstruction. In oral and maxillofacial reconstruction applications, DO is playing an important role as a technique without the need of bon...

    Authors: Shahrokh Hatefi, Katayoun Hatefi, Francis Le Roux, Javad Alizargar, Zeinolabedin Behdadipour, Yimesker Yihun and Khaled Abou-El-Hossein

    Citation: BioMedical Engineering OnLine 2020 19:17

    Content type: Review

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  39. It was highlighted that the original article [1] contained an error in the Quantitative evaluation of Methods. A bracket was misplaced in the formula. This Correction article shows the incorrect and correct fo...

    Authors: Cuixia Feng, Hulin Zhao, Maoyu Tian, Miaomiao Lu and Junhai Wen

    Citation: BioMedical Engineering OnLine 2020 19:16

    Content type: Correction

    Published on:

    The original article was published in BioMedical Engineering OnLine 2020 19:13

  40. Previous in vitro studies demonstrated that suppression of microRNAs might protect cardiomyocytes and neurons against oxygen–glucose deprivation and reoxygenation (OGD/R)-induced cell apoptosis. However, wheth...

    Authors: Wei Hou, Xianting Zhu, Juan Liu and Jiaguo Map

    Citation: BioMedical Engineering OnLine 2020 19:15

    Content type: Research

    Published on:

    The Correction to this article has been published in BioMedical Engineering OnLine 2020 19:43

  41. Reach–grasp movements are motor components commonly affected after stroke and directly related to the independence of these individuals. Evaluations of these activities can be performed using clinical instrume...

    Authors: Camila L. A. Gomes, Roberta O. Cacho, Viviane T. B. Nobrega, Ellen Marjorie de A. Confessor, Eyshila Emanuelle M. de Farias, José Leôncio F. Neto, Denise S. de Araújo, Ana Loyse de S. Medeiros, Rodrigo L. Barreto and Enio W. A. Cacho

    Citation: BioMedical Engineering OnLine 2020 19:14

    Content type: Research

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  42. Focal cortical dysplasia (FCD) is a neuronal migration disorder and is a major cause of drug-resistant epilepsy. However, many focal abnormalities remain undetected during routine visual inspection, and many p...

    Authors: Cuixia Feng, Hulin Zhao, Maoyu Tian, Miaomiao Lu and Junhai Wen

    Citation: BioMedical Engineering OnLine 2020 19:13

    Content type: Research

    Published on:

    The Correction to this article has been published in BioMedical Engineering OnLine 2020 19:16

  43. Bone defects are often combined with the risk of infection in the clinic, and artificial bone substitutes are often implanted to repair the defective bone. However, the implant materials are carriers for bacte...

    Authors: Rui Ma, Wei Wang, Pei Yang, Chunsheng Wang, Dagang Guo and Kunzheng Wang

    Citation: BioMedical Engineering OnLine 2020 19:12

    Content type: Research

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  44. Randomized Controlled Trials (RCTs) are the best method to determine causal effects for treatments if they are well done and well reported. Good evidence about proposed treatments for obesity is needed, and Hs...

    Authors: Luis M. Mestre, Stephanie L. Dickinson, Lilian Golzarri-Arroyo, Andrew W. Brown and David B. Allison

    Citation: BioMedical Engineering OnLine 2020 19:11

    Content type: Letter to the Editor

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  45. Epilepsy is one of the most common neurological disorders associated with disruption of brain activity. In the classification and detection of epileptic seizures, electroencephalography (EEG) measurements, whi...

    Authors: Ozlem Karabiber Cura, Sibel Kocaaslan Atli, Hatice Sabiha Türe and Aydin Akan

    Citation: BioMedical Engineering OnLine 2020 19:10

    Content type: Research

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  46. The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering,...

    Authors: Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen and Xiuqing Gong

    Citation: BioMedical Engineering OnLine 2020 19:9

    Content type: Review

    Published on:

  47. Uniaxial/biaxial tensile stress has been employed to induce chondrocyte differentiation of mesenchymal stem cells. However, the effects of radial tensile stimuli on differentiation of MSCs into fibrocartilage ...

    Authors: Xuelian Su, Jizeng Wang, Hong Kang, Guangjie Bao and Lin Liu

    Citation: BioMedical Engineering OnLine 2020 19:8

    Content type: Research

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  48. Cochlear implants (CIs) have become important for the treatment of severe-to-profound sensorineural hearing loss (SNHL). Meanwhile, electrically evoked compound action potentials (ECAPs) and electrically evoke...

    Authors: Tianhao Lu, Qiang Li, Chen Zhang, Min Chen, Zhengming Wang and Shufeng Li

    Citation: BioMedical Engineering OnLine 2020 19:7

    Content type: Research

    Published on: