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  1. Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation of the epidemiological c...

    Authors: Yiyi Yao, Xiangjie Lin, Fenglin Li, Jie Jin and Huafeng Wang

    Citation: BioMedical Engineering OnLine 2022 21:4

    Content type: Research

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  2. Demographic change is leading to an increase in the number of osteoporotic patients, so a rethink is required in implantology in order to be able to guarantee adequate anchoring stability in the bone. The func...

    Authors: Isabell Hamann, Stefan Schleifenbaum, Christian Rotsch, Welf-Guntram Drossel, Christoph-Eckhard Heyde and Mario Leimert

    Citation: BioMedical Engineering OnLine 2022 21:3

    Content type: Research

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  3. The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long noncoding RNAs (lncRNAs) govern a variety of biological processes, such as EMT...

    Authors: Zhixiong Chen, Xi Chu and Jinghong Xu

    Citation: BioMedical Engineering OnLine 2022 21:2

    Content type: Research

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  4. Excessive aggregation of β-amyloid peptides (Aβ) is regarded as the hallmark of Alzheimer’s disease. Exploring the underlying mechanism regulating Aβ aggregation remains challenging and investigating aggregati...

    Authors: Yang Xie, Lin Yu, Yuna Fu, Heng Sun and Jianhua Wang

    Citation: BioMedical Engineering OnLine 2021 20:132

    Content type: Research

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  5. Image registration is an essential step in the automated interpretation of the brain computed tomography (CT) images of patients with acute cerebrovascular disease (ACVD). However, performing brain CT registra...

    Authors: Hongmei Yuan, Minglei Yang, Shan Qian, Wenxin Wang, Xiaotian Jia and Feng Huang

    Citation: BioMedical Engineering OnLine 2021 20:131

    Content type: Research

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  6. Ankle sprain affects the structure and function of ankle cartilage. However, it is not clear whether the daily training and competition affect the ankle cartilage without acute injury. Changes in ankle cartila...

    Authors: Sipin Luo, Yi Cao, Peng Hu, Nan Wang and Yeda Wan

    Citation: BioMedical Engineering OnLine 2021 20:130

    Content type: Research

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  7. Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRN...

    Authors: Shumin Xie, Li Jin, Tuanfang Yin, Jihao Ren and Wei Liu

    Citation: BioMedical Engineering OnLine 2021 20:129

    Content type: Research

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  8. Wogonin (5, 7-dihydroxy-8-methoxyflavone) is a natural di-hydroxyl flavonoid extracted from the root of Scutellaria baicalensis Georgi. This paper was intended to investigate the mechanism of action of wogonin in...

    Authors: Jinlin Ge, Huanhuan Yang, Yufeng Zeng and Yunjie Liu

    Citation: BioMedical Engineering OnLine 2021 20:125

    Content type: Research

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  9. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) is the most sensitive technique for evaluating gene expression levels. Choosing appropriate reference genes (RGs) is critical for normaliz...

    Authors: Qiang Song, Lu Dou, Wenjin Zhang, Yang Peng, Man Huang and Mengyuan Wang

    Citation: BioMedical Engineering OnLine 2021 20:124

    Content type: Research

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  10. The COVID-19 disease is putting unprecedented pressure on the global healthcare system. The CT (computed tomography) examination as a auxiliary confirmed diagnostic method can help clinicians quickly detect le...

    Authors: Wei Li, Yangyong Cao, Kun Yu, Yibo Cai, Feng Huang, Minglei Yang and Weidong Xie

    Citation: BioMedical Engineering OnLine 2021 20:123

    Content type: Research

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  11. Heart rate (HR) is an important vital sign for evaluating the physiological condition of a newborn infant. Recently, for measuring HR, novel RGB camera-based non-contact techniques have demonstrated their specifi...

    Authors: Qiong Chen, Yalin Wang, Xiangyu Liu, Xi Long, Bin Yin, Chen Chen and Wei Chen

    Citation: BioMedical Engineering OnLine 2021 20:122

    Content type: Research

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  12. Automated tools for landmarking the internal carotid artery (ICA) bends have the potential for efficient and objective medical image-based morphometric analysis. The two existing algorithms rely on numerical a...

    Authors: Henrik A Kjeldsberg, Aslak W Bergersen and Kristian Valen-Sendstad

    Citation: BioMedical Engineering OnLine 2021 20:120

    Content type: Review

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  13. Long-leg-radiography (LLR) is commonly used for the measurement of lower limb alignment. However, limb rotations during radiography may interfere with the alignment measurement. This study examines the effect ...

    Authors: Xiaoshu Sun, Bin Yang, Shengzhao Xiao, Yichen Yan, Zifan Liu, Liang Yuan, Xiaohua Wang, Bin Sun, Jie Yao and Yubo Fan

    Citation: BioMedical Engineering OnLine 2021 20:119

    Content type: Research

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  14. Running on sand could be a promising exercise intervention for the treatment of over-pronated feet. However, there is a lack of knowledge about the effects of running on sand on muscle activities. Therefore, t...

    Authors: AmirAli Jafarnezhadgero, Amir Fatollahi, Ali Sheykholeslami, Valdeci Carlos Dionisio and Mohammad Akrami

    Citation: BioMedical Engineering OnLine 2021 20:118

    Content type: Research

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  15. Lung adenocarcinoma (LUAD) is the most common subtype of nonsmall-cell lung cancer (NSCLC) and has a high incidence rate and mortality. The survival of LUAD patients has increased with the development of targe...

    Authors: Yumiao Li, Xiaoxue Yu, Yuhao Zhang, Xiaofang Wang, Linshan Zhao, Dan Liu, Guofa Zhao, Xiangpeng Gao, Jiejun Fu, Aimin Zang and Youchao Jia

    Citation: BioMedical Engineering OnLine 2021 20:117

    Content type: Research

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  16. Large bone defects have always been a great challenge for orthopedic surgeons. The use of a good bone substitute obtained by bone tissue engineering (BTE) may be an effective treatment method. Artificial hydro...

    Authors: Chengyong Li, Tingting Yan, Zhenkai Lou, Zhimin Jiang, Zhi Shi, Qinghua Chen, Zhiqiang Gong and Bing Wang

    Citation: BioMedical Engineering OnLine 2021 20:116

    Content type: Research

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  17. Nanomaterials of biomedicine and tissue engineering have been proposed for the treatment of periodontitis in recent years. This study aimed to investigate the effects of gold nanoparticles (AuNPs) combined wit...

    Authors: Jing Zhou, Lingjun Li, Di Cui, Xiaoting Xie, Wenrong Yang and Fuhua Yan

    Citation: BioMedical Engineering OnLine 2021 20:115

    Content type: Research

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  18. Automatic voice condition analysis systems to detect Parkinson’s disease (PD) are generally based on speech data recorded under acoustically controlled conditions and professional supervision. The performance ...

    Authors: Javier Carrón, Yolanda Campos-Roca, Mario Madruga and Carlos J. Pérez

    Citation: BioMedical Engineering OnLine 2021 20:114

    Content type: Research

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  19. The corneal biomechanical properties with the prolongation of time after corneal refractive surgery are important for providing a mechanical basis for the occurrence of clinical phenomena such as iatrogenic ke...

    Authors: Di Zhang, Xiao Qin, Haixia Zhang and Lin Li

    Citation: BioMedical Engineering OnLine 2021 20:113

    Content type: Research

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  20. The rapid development of artificial intelligence technology has improved the capability of automatic breast cancer diagnosis, compared to traditional machine learning methods. Convolutional Neural Network (CNN...

    Authors: He Ma, Ronghui Tian, Hong Li, Hang Sun, Guoxiu Lu, Ruibo Liu and Zhiguo Wang

    Citation: BioMedical Engineering OnLine 2021 20:112

    Content type: Research

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  21. The purpose of this study was to explore whether moderate-intensity exercise can alleviate motion-induced post-traumatic osteoarthritis (PTOA) and the expression change of lncRNA H19 during this progression.

    Authors: Xuchang Zhou, Hong Cao, Miao Wang, Jun Zou and Wei Wu

    Citation: BioMedical Engineering OnLine 2021 20:111

    Content type: Research

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  22. Percutaneous transluminal coronary angioplasty (PTCA) balloon catheters must withstand high pressures required for the lesion treatment, pushing loads during insertion, and pulling loads during withdrawal. The...

    Authors: C. Amstutz, B. Weisse, S. Valet, A. Haeberlin, J. Burger and A. Zurbuchen

    Citation: BioMedical Engineering OnLine 2021 20:110

    Content type: Research

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  23. Striae gravidarum is a common occurrence in pregnancy and many women expect to prevent its development. At present, laser treatment has been used to improve the appearance of striae gravidarum, but the choice ...

    Authors: Hongyan Dai, Yangyang Liu, Yan Zhu, Yun Yu and Lin Meng

    Citation: BioMedical Engineering OnLine 2021 20:109

    Content type: Research

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    The Correction to this article has been published in BioMedical Engineering OnLine 2021 20:128

  24. Global measures of neuronal activity embrace the advantage of a univariate, holistic and unique description of brain activity, reducing the spatial dimensions of electroencephalography (EEG) analysis at the co...

    Authors: Anastasios E. Giannopoulos, Sotirios T. Spantideas, Christos Capsalis, Panos Papageorgiou, Nikolaos Kapsalis, Konstantinos Kontoangelos and Charalabos Papageorgiou

    Citation: BioMedical Engineering OnLine 2021 20:108

    Content type: Research

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  25. Image-guided adaptive brachytherapy shows the ability to deliver high doses to tumors while sparing normal tissues. However, interfraction dose delivery introduces uncertainties to high dose estimation, which ...

    Authors: Binbing Wang, Weibiao Hu, Guoping Shan and Xiaoxian Xu

    Citation: BioMedical Engineering OnLine 2021 20:106

    Content type: Research

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  26. Cyclic motor patterns (CMP) are the predominant motor pattern in the distal colon, and are important in both health and disease. Their origin, mechanism and relation to bioelectrical slow-waves remain incomple...

    Authors: Anthony Y. Lin, Chris Varghese, Peng Du, Cameron I. Wells, Niranchan Paskaranandavadivel, Armen A. Gharibans, Jonathan C. Erickson, Ian P. Bissett and Greg O’Grady

    Citation: BioMedical Engineering OnLine 2021 20:105

    Content type: Research

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  27. Walking mechanics recorded with a traditional treadmill may not be the same as the mechanics exhibited during activities of daily living due to constrained walking speeds. Adaptive-speed treadmills allow for u...

    Authors: Sheridan M. Parker, Jeremy Crenshaw, Nathaniel H. Hunt, Christopher Burcal and Brian A. Knarr

    Citation: BioMedical Engineering OnLine 2021 20:104

    Content type: Research

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  28. Traditional Chinese medicine has been found effective for the therapy of knee osteoarthritis (KOA). This study was aimed at investigating the underlying mechanism of Bugan Rongjin decoction (BGRJ) in treating ...

    Authors: Sheng Wang, Pei Ding, Xiaopeng Xia, Xuexian Chen, Daguo Mi, Shuijie Sheng, Fulong Gu, Zhongwei Li, Kelei Su and Yuwei Li

    Citation: BioMedical Engineering OnLine 2021 20:103

    Content type: Research

    Published on:

  29. Retinal degenerative diseases, e.g., retinitis pigmentosa, cause a severe decline of the visual function up to blindness. Treatment still remains difficult; however, implantation of retinal prostheses can help...

    Authors: Kim Schaffrath, Tibor Lohmann, Jan Seifert, Claudia Ingensiep, Pascal Raffelberg, Florian Waschkowski, Reinhard Viga, Rainer Kokozinski, Wilfried Mokwa, Sandra Johnen and Peter Walter

    Citation: BioMedical Engineering OnLine 2021 20:102

    Content type: Research

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  30. Neural-network methods have been widely used for the prediction of dose distributions in radiotherapy. However, the prediction accuracy of existing methods may be degraded by the problem of dose imbalance. In ...

    Authors: Xue Bai, Jie Zhang, Binbing Wang, Shengye Wang, Yida Xiang and Qing Hou

    Citation: BioMedical Engineering OnLine 2021 20:101

    Content type: Research

    Published on:

  31. Intracranial aneurysm rupture is the main cause of subarachnoid hemorrhage, leading to high disability and mortality. This study aimed to evaluate the clinical treatment effects of multiple overlapping stent-a...

    Authors: Lingtong You, Jiaxin Huang, Jinning Zhang and Zhixian Jiang

    Citation: BioMedical Engineering OnLine 2021 20:100

    Content type: Research

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  32. Posterior pedicle screw (PS) fixation, a common treatment method for widespread low-back pain problems, has many uncertain aspects including stress concentration levels, effects on adjacent segments, and relat...

    Authors: Emre Sengul, Ramazan Ozmen, Mesut Emre Yaman and Teyfik Demir

    Citation: BioMedical Engineering OnLine 2021 20:98

    Content type: Research

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  33. Retinal biomarkers of Alzheimer’s disease (AD) have been extensively investigated in recent decades. Retinal nervous and vascular parameters can reflect brain conditions, and they can facilitate early diagnosi...

    Authors: Xi Mei, Conglong Qiu, Qi Zhou, Zhongming Chen, Yang Chen, Zemin Xu and Chenjun Zou

    Citation: BioMedical Engineering OnLine 2021 20:97

    Content type: Research

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  34. Because of osteoporosis, traffic accidents, falling from high places, and other reasons, the vertebral body can be compressed and even collapse. Vertebral implants can be used for clinical treatment. Because o...

    Authors: Yuan Guo, Jing Liu, Xushu Zhang, Zejun Xing, Weiyi Chen and Di Huang

    Citation: BioMedical Engineering OnLine 2021 20:96

    Content type: Research

    Published on:

  35. Coronary artery disease is an abnormal contraction of the heart supply blood vessel. It limits the oxygenated blood flow to the heart. Thus, diagnosing its severity helps physicians to select the appropriate t...

    Authors: Yasser Abuouf, Muhamed AlBadawi, Shinichi Ookawara and Mahmoud Ahmed

    Citation: BioMedical Engineering OnLine 2021 20:95

    Content type: Research

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  36. Accurate segmentation of lung lobe on routine computed tomography (CT) images of locally advanced stage lung cancer patients undergoing radiotherapy can help radiation oncologists to implement lobar-level trea...

    Authors: Hengle Gu, Wutian Gan, Chenchen Zhang, Aihui Feng, Hao Wang, Ying Huang, Hua Chen, Yan Shao, Yanhua Duan and Zhiyong Xu

    Citation: BioMedical Engineering OnLine 2021 20:94

    Content type: Research

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  37. Individuals with gaming disorder (GD) exhibit autonomic nervous system responses that indicate dysfunctional emotion regulation. Pulse rate variability (PRV) is a valuable biomarker for investigating the auton...

    Authors: Hung-Ming Chi and Tzu-Chien Hsiao

    Citation: BioMedical Engineering OnLine 2021 20:93

    Content type: Research

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  38. Acoustic cavitation plays an important role in the medical treatment using high-intensity focused ultrasound (HIFU), but unnecessarily strong cavitation also could deform the morphology and enlarge the size of...

    Authors: Min He, Zhiqiang Zhong, Deping Zeng, Xiaobo Gong, Zhibiao Wang and Faqi Li

    Citation: BioMedical Engineering OnLine 2021 20:91

    Content type: Research

    Published on:

  39. Ataxic gait is one of the most common and disabling symptoms in people with degenerative cerebellar ataxia. Intensive and well-coordinated inpatient rehabilitation improves ataxic gait. In addition to therapis...

    Authors: Akira Matsushima, Yoichi Maruyama, Noriaki Mizukami, Mikio Tetsuya, Minoru Hashimoto and Kunihiro Yoshida

    Citation: BioMedical Engineering OnLine 2021 20:90

    Content type: Research

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  40. Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role of hy...

    Authors: Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Meng Yan and Jun Xiao

    Citation: BioMedical Engineering OnLine 2021 20:88

    Content type: Research

    Published on: