Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond

Authors: Dalin Tang and Zhi-Yong Li

Numerical simulation of closure performance for neo-aortic valve for arterial switch operation

Modeling neo-aortic valve for arterial switch surgical planning to simulate the neo-aortic valve closure performance.

Authors: Zhaoyong Gu, Youlian Pan, Aike Qiao, Xingjian Hu, Nianguo Dong, Xiaofeng Li, Yinglong Liu and Deguang Shang

Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE^−/− mice

This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of...

Authors: Bing Li, Yun Jiao, Cong Fu, Bo Xie, Genshan Ma, Gaojun Teng and Yuyu Yao

Association of simultaneously measured four-limb blood pressures with cardiovascular function: a cross-sectional study

Simultaneous measurement of four-limb blood pressures can improve the accuracy of cardiovascular disease diagnosis. This study aims to investigate the association of simultaneously measured four-limb blood pre...

Authors: Xiaorui Song, Gaoyang Li, Aike Qiao and Zhihui Chen

Mathematically modeling fluid flow and fluid shear stress in the canaliculi of a loaded osteon

Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects, such as fluid flow and fluid shear stress (FSS), which may enable bone cells to detect external mechanical sign...

Authors: Xiaogang Wu, Ningning Wang, Zhaowei Wang, Weilun Yu, Yanqin Wang, Yuan Guo and Weiyi Chen

Multi-objective optimization of coronary stent using Kriging surrogate model

In stent design optimization, the functional relationship between design parameters and design goals is nonlinear, complex, and implicit and the multi-objective design of stents involves a number of potentiall...

Authors: Hongxia Li, Junfeng Gu, Minjie Wang, Danyang Zhao, Zheng Li, Aike Qiao and Bao Zhu

The study on hemodynamic effect of series type LVAD on aortic blood flow pattern: a primary numerical study

Left ventricular assist device (LVAD) has become an alternative treatment for end-stage heart failure patients. Series type of LVAD, as a novel LVAD, has attracted more and more attention. The hemodynamic effe...

Authors: Qi Zhang, Bin Gao and Yu Chang

Finite element analysis of the valgus knee joint of an obese child

Knee valgus and varus morbidity is at the second top place in children lower limb deformity diseases. It may cause abnormal stress distribution. The magnitude and location of contact forces on tibia plateau du...

Authors: Jun Sun, Songhua Yan, Yan Jiang, Duo Wai-chi Wong, Ming Zhang, Jizhou Zeng and Kuan Zhang

Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork

The intraocular pressure (IOP) is maintained through a dynamic equilibrium between the production and drainage of aqueous humor. Elevation of intraocular pressure is mainly caused by the blocking of aqueous hu...

Authors: Jing Zhang, Lin Ren, Xi Mei, Qiang Xu, Wei Zheng and Zhicheng Liu

Cerebral and neural regulation of cardiovascular activity during mental stress

Mental arithmetic has been verified inducing cerebral and cardiovascular responses. However, the mechanism and sequential responses are still ambiguous. This study aims to reveal the mechanism of cardiovascula...

Authors: Xiaoni Wang, Binbin Liu, Lin Xie, Xiaolin Yu, Mengjun Li and Jianbao Zhang

SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries

Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shape...

Authors: Hasitha-Nayanajith Polwaththe-Gallage, Suvash C. Saha, Emilie Sauret, Robert Flower, Wijitha Senadeera and YuanTong Gu

Towards the patient-specific design of flow diverters made from helix-like wires: an optimization study

Flow diverter (FD) intervention is an emerging endovascular technique for treating intracranial aneurysms. High flow-diversion efficiency is desired to accelerate thrombotic occlusion inside the aneurysm; howe...

Authors: Mingzi Zhang, Hitomi Anzai, Bastien Chopard and Makoto Ohta

Compression-distraction reduction surgical verification and optimization to treat the basilar invagination and atlantoaxial dislocation: a finite element analysis

Basilar invagination (BI) combined with atlantoaxial dislocation (AAD) leads to foramen magnum stenosis and medullary spinal cord compression, causing nerve dysfunction. The purpose of the surgery is to remove...

Authors: Xuefeng Bo, Weida Wang, Zan Chen and Zhicheng Liu

The effect of captopril on the performance of the control strategies of BJUT-II VAD

With the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacol...

Authors: Kaiyun Gu, Bin Gao, Yu Chang and Yi Zeng

Hemodynamics study of a multilayer stent for the treatment of aneurysms

The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac.

Authors: Yan Xiong, Xuhong Wang, Wentao Jiang, Xiaobao Tian, Qingyuan Wang, Yubo Fan and Yu Chen

Influence of endoleak positions on the pressure shielding ability of stent-graft after endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA)

Abdominal aortic aneurysm (AAA) is a kind of dangerous aortic vascular disease, which is characterized by abdominal aorta partial enlargement. At present, endovascular aneurysm repair (EVAR) is one of the main...

Authors: Jie Li, Xiaopeng Tian, Zhenze Wang, Jiang Xiong, Yubo Fan, Xiaoyan Deng, Anqiang Sun and Xiao Liu

Phantom-based experimental validation of fast virtual deployment of self-expandable stents for cerebral aneurysms

Endovascular intervention using a stent is a mainstream treatment for cerebral aneurysms. To assess the effect of intervention strategies on aneurysm hemodynamics, we have developed a fast virtual stenting (FV...

Authors: Qianqian Zhang, Zhuangyuan Meng, Ying Zhang, Kai Yao, Jian Liu, Yisen Zhang, Linkai Jing, Xinjian Yang, Nikhil Paliwal, Hui Meng and Shengzhang Wang

The comparison of lesion outline and temperature field determined by different ways in atrial radiofrequency ablation

The aim of this study is to research the lesion outline and temperature field in different ways in atrial radiofrequency ablation by using finite element method.

Authors: Zhen Tian, Qun Nan, Xiaohui Nie, Tong Dong and Ruirui Wang

T2-prepared segmented 3D-gradient-echo for fast T2-weighted high-resolution three-dimensional imaging of the carotid artery wall at 3T: a feasibility study

The multi-contrast assessment of the carotid artery wall has become an important diagnostic tool for the characterization of atherosclerotic plaque and vessel wall thickening. For providing the required T1-, T...

Authors: Jian Zhu, Axel Bornstedt, Nico Merkle, Naifeng Liu, Wolfgang Rottbauer, Genshan Ma and Volker Rasche

Exploring potential association between flow instability and rupture in patients with matched-pairs of ruptured–unruptured intracranial aneurysms

Patients with multiple intracranial aneurysms present a great challenge to the neurosurgeon, particularly when presenting with subarachnoid hemorrhage. Misjudgment may result in disastrous postoperative reblee...

Authors: Lijian Xu, Lixu Gu and Hao Liu