Computational and Experimental Methods for Biological Research: Cardiovascular Diseases and Beyond

Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond

Authors: Dalin Tang and Zhi-Yong Li

Numerical simulation of closure performance for neo-aortic valve for arterial switch operation

Modeling neo-aortic valve for arterial switch surgical planning to simulate the neo-aortic valve closure performance.

Authors: Zhaoyong Gu, Youlian Pan, Aike Qiao, Xingjian Hu, Nianguo Dong, Xiaofeng Li, Yinglong Liu and Deguang Shang

Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE^−/− mice

This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of...

Authors: Bing Li, Yun Jiao, Cong Fu, Bo Xie, Genshan Ma, Gaojun Teng and Yuyu Yao

Association of simultaneously measured four-limb blood pressures with cardiovascular function: a cross-sectional study

Simultaneous measurement of four-limb blood pressures can improve the accuracy of cardiovascular disease diagnosis. This study aims to investigate the association of simultaneously measured four-limb blood pre...

Authors: Xiaorui Song, Gaoyang Li, Aike Qiao and Zhihui Chen

Mathematically modeling fluid flow and fluid shear stress in the canaliculi of a loaded osteon

Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects, such as fluid flow and fluid shear stress (FSS), which may enable bone cells to detect external mechanical sign...

Authors: Xiaogang Wu, Ningning Wang, Zhaowei Wang, Weilun Yu, Yanqin Wang, Yuan Guo and Weiyi Chen

Multi-objective optimization of coronary stent using Kriging surrogate model

In stent design optimization, the functional relationship between design parameters and design goals is nonlinear, complex, and implicit and the multi-objective design of stents involves a number of potentiall...

Authors: Hongxia Li, Junfeng Gu, Minjie Wang, Danyang Zhao, Zheng Li, Aike Qiao and Bao Zhu

The study on hemodynamic effect of series type LVAD on aortic blood flow pattern: a primary numerical study

Left ventricular assist device (LVAD) has become an alternative treatment for end-stage heart failure patients. Series type of LVAD, as a novel LVAD, has attracted more and more attention. The hemodynamic effe...

Authors: Qi Zhang, Bin Gao and Yu Chang

Finite element analysis of the valgus knee joint of an obese child

Knee valgus and varus morbidity is at the second top place in children lower limb deformity diseases. It may cause abnormal stress distribution. The magnitude and location of contact forces on tibia plateau du...

Authors: Jun Sun, Songhua Yan, Yan Jiang, Duo Wai-chi Wong, Ming Zhang, Jizhou Zeng and Kuan Zhang

Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork

The intraocular pressure (IOP) is maintained through a dynamic equilibrium between the production and drainage of aqueous humor. Elevation of intraocular pressure is mainly caused by the blocking of aqueous hu...

Authors: Jing Zhang, Lin Ren, Xi Mei, Qiang Xu, Wei Zheng and Zhicheng Liu

Cerebral and neural regulation of cardiovascular activity during mental stress

Mental arithmetic has been verified inducing cerebral and cardiovascular responses. However, the mechanism and sequential responses are still ambiguous. This study aims to reveal the mechanism of cardiovascula...

Authors: Xiaoni Wang, Binbin Liu, Lin Xie, Xiaolin Yu, Mengjun Li and Jianbao Zhang

SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries

Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shape...

Authors: Hasitha-Nayanajith Polwaththe-Gallage, Suvash C. Saha, Emilie Sauret, Robert Flower, Wijitha Senadeera and YuanTong Gu

Towards the patient-specific design of flow diverters made from helix-like wires: an optimization study

Flow diverter (FD) intervention is an emerging endovascular technique for treating intracranial aneurysms. High flow-diversion efficiency is desired to accelerate thrombotic occlusion inside the aneurysm; howe...

Authors: Mingzi Zhang, Hitomi Anzai, Bastien Chopard and Makoto Ohta

Compression-distraction reduction surgical verification and optimization to treat the basilar invagination and atlantoaxial dislocation: a finite element analysis

Basilar invagination (BI) combined with atlantoaxial dislocation (AAD) leads to foramen magnum stenosis and medullary spinal cord compression, causing nerve dysfunction. The purpose of the surgery is to remove...

Authors: Xuefeng Bo, Weida Wang, Zan Chen and Zhicheng Liu

The effect of captopril on the performance of the control strategies of BJUT-II VAD

With the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacol...

Authors: Kaiyun Gu, Bin Gao, Yu Chang and Yi Zeng

Hemodynamics study of a multilayer stent for the treatment of aneurysms

The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac.

Authors: Yan Xiong, Xuhong Wang, Wentao Jiang, Xiaobao Tian, Qingyuan Wang, Yubo Fan and Yu Chen

Influence of endoleak positions on the pressure shielding ability of stent-graft after endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA)

Abdominal aortic aneurysm (AAA) is a kind of dangerous aortic vascular disease, which is characterized by abdominal aorta partial enlargement. At present, endovascular aneurysm repair (EVAR) is one of the main...

Authors: Jie Li, Xiaopeng Tian, Zhenze Wang, Jiang Xiong, Yubo Fan, Xiaoyan Deng, Anqiang Sun and Xiao Liu

Phantom-based experimental validation of fast virtual deployment of self-expandable stents for cerebral aneurysms

Endovascular intervention using a stent is a mainstream treatment for cerebral aneurysms. To assess the effect of intervention strategies on aneurysm hemodynamics, we have developed a fast virtual stenting (FV...

Authors: Qianqian Zhang, Zhuangyuan Meng, Ying Zhang, Kai Yao, Jian Liu, Yisen Zhang, Linkai Jing, Xinjian Yang, Nikhil Paliwal, Hui Meng and Shengzhang Wang

The comparison of lesion outline and temperature field determined by different ways in atrial radiofrequency ablation

The aim of this study is to research the lesion outline and temperature field in different ways in atrial radiofrequency ablation by using finite element method.

Authors: Zhen Tian, Qun Nan, Xiaohui Nie, Tong Dong and Ruirui Wang

T2-prepared segmented 3D-gradient-echo for fast T2-weighted high-resolution three-dimensional imaging of the carotid artery wall at 3T: a feasibility study

The multi-contrast assessment of the carotid artery wall has become an important diagnostic tool for the characterization of atherosclerotic plaque and vessel wall thickening. For providing the required T1-, T...

Authors: Jian Zhu, Axel Bornstedt, Nico Merkle, Naifeng Liu, Wolfgang Rottbauer, Genshan Ma and Volker Rasche

Exploring potential association between flow instability and rupture in patients with matched-pairs of ruptured–unruptured intracranial aneurysms

Patients with multiple intracranial aneurysms present a great challenge to the neurosurgeon, particularly when presenting with subarachnoid hemorrhage. Misjudgment may result in disastrous postoperative reblee...

Authors: Lijian Xu, Lixu Gu and Hao Liu

Numerical study of the effects of bronchial structural abnormalities on respiratory flow distribution

The anatomical configurations of respiratory tract would be directly associated with their ventilatory function. It is necessary to fully understand the association between airway configurations and their func...

Authors: Shen Yu, Jizhe Wang, Xiuzhen Sun and Yingxi Liu

Re-examination of the mechanical anisotropy of porcine thoracic aorta by uniaxial tensile tests

Considering past studies on the orthotropic anisotropy of arteries in the circumferential and axial directions, this work aims to experimentally study the anisotropic behaviour of arteries by tensioning multi-...

Authors: Qiang Chen, Yan Wang and Zhi-Yong Li

The biomechanical significance of pulley on binocular vision

Pulleys have been reported as the functional origins of the rectus extraocular muscles (EOMs). However, biomechanical significance of pulleys on binocular vision has not been reported.

Authors: Hongmei Guo, Zhipeng Gao and Weiyi Chen

The movement and deposition of PM2.5 in the upper respiratory tract for the patients with heart failure: an elementary CFD study

PM2.5 is an important factor to affect the patients with respiratory and cardiovascular diseases. Clinical studies have found that the morbidity and mortality of patients with heart failure (HF) have a close r...

Authors: Tiantian Zhang, Bin Gao, Zhixiang Zhou and Yu Chang

The risk of stanford type-A aortic dissection with different tear size and location: a numerical study

This study is to investigate the influence of hemodynamics on Stanford type-A aortic dissection with different tear size and location, to provide some support for the relationships between the risks (rupture, ...

Authors: Yue Shi, Minjia Zhu, Yu Chang, Huanyu Qiao and Yongmin Liu

Hemodynamic analysis of sequential graft from right coronary system to left coronary system

Sequential and single grafting are two surgical procedures of coronary artery bypass grafting. However, it remains unclear if the sequential graft can be used between the right and left coronary artery system....

Authors: Wenxin Wang, Boyan Mao, Haoran Wang, Xueying Geng, Xi Zhao, Huixia Zhang, Jinsheng Xie, Zhou Zhao, Bo Lian and Youjun Liu

On the relationship between competitive flow and FFT analysis of the flow waves in the left internal mammary artery graft in the process of CABG

During coronary artery bypass grafting (CABG), the ratio of powers of the fundamental frequency and its first harmonic (F0/H1) in fast Fourier transformation (FFT) analysis of the graft’s flow waves has been u...

Authors: Boyan Mao, Wenxin Wang, Zhou Zhao, Xi Zhao, Lanlan Li, Huixia Zhang and Youjun Liu

Fluid and structure coupling analysis of the interaction between aqueous humor and iris

Glaucoma is the primary cause of irreversible blindness worldwide associated with high intraocular pressure (IOP). Elevated intraocular pressure will affect the normal aqueous humor outflow, resulting in defor...

Authors: Wenjia Wang, Xiuqing Qian, Hongfang Song, Mindi Zhang and Zhicheng Liu

Numerical prediction of thrombus risk in an anatomically dilated left ventricle: the effect of inflow cannula designs

Implantation of a rotary blood pump (RBP) can cause non-physiological flow fields in the left ventricle (LV) which may trigger thrombosis. Different inflow cannula geometry can affect LV flow fields. The aim o...

Authors: Sam Liao, Benjamin Simpson, Michael Neidlin, Tim A. S. Kaufmann, Zhiyong Li, Maria A. Woodruff and Shaun D. Gregory

β1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model

Keratinocyte (KC) migration in re-epithelization is crucial in repairing injured skin. But the mechanisms of how mechanical stimuli regulate the migration of keratinocytes have been poorly understood.

Authors: Dongyuan Lü, Zhan Li, Yuxin Gao, Chunhua Luo, Fan Zhang, Lu Zheng, Jiawen Wang, Shujin Sun and Mian Long

Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress

Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model....

Authors: Ruoyu Xing, David De Wilde, Gayle McCann, Yanto Ridwan, Jelle T. C. Schrauwen, Anton F. W. van der Steen, Frank J. H. Gijsen and Kim Van der Heiden

Mechanical regulation of calcium signaling of HL-60 on P-selectin under flow

Binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) makes neutrophils roll on and adhere to inflammatory site. Intracellular calcium bursting of adhered neutrophils is a key event for subsequent...

Authors: Bing Huang, Yingchen Ling, Jiangguo Lin, Ying Fang and Jianhua Wu

Computer prediction of paratope on antithrombotic antibody 10B12 and epitope on platelet glycoprotein VI via molecular dynamics simulation

Interaction between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. Of various antithrombotic agents targeting GPVI, anti...

Authors: Wenping Liu, Guangjian Liu, Huiyun Zhou, Xiang Fang, Ying Fang and Jianhua Wu

A multi-component parallel-plate flow chamber system for studying the effect of exercise-induced wall shear stress on endothelial cells

In vivo studies have demonstrated that reasonable exercise training can improve endothelial function. To confirm the key role of wall shear stress induced by exercise on endothelial cells, and to understand ho...

Authors: Yan-Xia Wang, Cheng Xiang, Bo Liu, Yong Zhu, Yong Luan, Shu-Tian Liu and Kai-Rong Qin

Effects of 8-week swimming training on carotid arterial stiffness and hemodynamics in young overweight adults

Exercise has been found to either reduce or increase arterial stiffness. Land-based exercise modalities have been documented as effective physical therapies to decrease arterial stiffness. However, these land-...

Authors: Wen-Xue Yuan, Hai-Bin Liu, Feng-Shan Gao, Yan-Xia Wang and Kai-Rong Qin

Multi-scale mathematical modelling of tumour growth and microenvironments in anti-angiogenic therapy

Angiogenesis, a process of generation of new blood vessels from the pre-existing vasculature, has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumour. Anti-angiogeni...

Authors: Yan Cai, Jie Zhang and Zhiyong Li