- Open Access
A compact theory of magnetic nerve stimulation: predicting how to aim
© Babbs; licensee BioMed Central Ltd. 2014
- Received: 24 December 2013
- Accepted: 17 April 2014
- Published: 30 April 2014
A compact theory that predicts quantitatively when and where magnetic neurostimulation will occur is needed as a guide to therapy, ideally providing a single equation that defines the target volume of tissue excited by single or dual coils.
A first-principles analysis of magnetic stimulation incorporating a simplified description of electromagnetic fields and a simplified cable theory of the axon yields a mathematical synthesis predicting how to aim.
Nerve stimulation produced by a single circular coil having one or more closely packed turns occurs in donut shaped volume of tissue beneath the coil. Axons spanning several millimeters are the sites of magnetic stimulation. The sites of maximal transmembrane depolarization in nerve fibers correspond to points where the axons enter or exit this volume of magnetically induced voltage and current. The axonal membrane at one end is depolarized locally during the rising phase of current in the coil. The axonal membrane at the opposite end is depolarized locally during the falling phase of current in the coil. Penetration depths of several centimeters from the skin surface or approximately one to two coil radii are practical. With two coils placed in a figure-of-eight configuration the separate clockwise and counterclockwise currents generate magnetic fields that add, producing maximal stimulation of a spindle shaped volume, centered at a depth of one-third to one-half coil radius from the body surface.
This condensed synthesis of electromagnetic theory and cable theories of axon physiology provides a partial solution to the targeting problem in peripheral and in transcranial magnetic stimulation.
- Transcranial Magnetic Stimulation
- Magnetic Flux
- Magnetic Stimulation
- Myelinated Axon
- Magnetic Pulse
Magnetic neurostimulation is a remarkable phenomenon. It is electrodeless, nearly painless, and dry—easily penetrating skin and bone, which usually provide high resistance barriers to current injected through ordinary contact electrodes [1–4]. Stimulating magnetic fields are produced by high intensity electric current, flowing in thick wire coils a few centimeters in diameter that are placed on or near the skin surface. Direct contact with the body surface is not needed. An air gap is perfectly acceptable. Coils placed near the skull can stimulate neurons in the cerebral cortex, a process known as transcranial magnetic stimulation or TMS [5–9]. When coils are placed over the motor strips of cerebral cortex, just above the ears, TMS can be used to test the function of motor tracts extending from head to toe or from head to fingertips [8, 10, 11]. Such testing can be useful in monitoring the functional integrity of the spinal cord during neurosurgery, helping to avoid the dreaded complication of postoperative paralysis [3, 12]. When coils are placed further forward over pre-frontal cortex TMS can be used treat psychic depression .
The current-carrying coils used to produce magnetic stimulation have one major drawback: they are hard to aim, producing diffuse stimulation. To reach its full potential magnetic neural stimulation needs to be better targeted. Although mapping of the magnetic fields in three dimensions is well understood [13, 14]; less work has been done to characterize the induced electric fields and eddy currents [2, 4, 15–17] and even less to understand quantitatively the physiological mechanisms by which nerve stimulation happens in this unusual setting [18, 19]. A successful working theory should allow one to predict which neurons will be stimulated at which orientations and at which distances from the axes of the coils . This latter problem requires particular attention to the effects on subthreshold membrane potentials of neurons . Practitioners need to be able to better visualize which nerve fibers in which volumes of space are likely to be excited by a defined magnetic pulse from single or double coils with a defined geometry. What is needed as a guide to therapy is a compact model that predicts quantitatively when and where neurostimulation will occur—ultimately, perhaps, providing a single equation that defines a target volume of tissue.
Magnetic fields are easily mapped and computed , and they can be measured routinely in a dry laboratory using small search coils , although even the search coil method has been criticized . However, the induced electric fields in volume conductors are not as easily computed or measured. Induced electrical potential gradients depend on the size and shape of any particular current loop or path and the presence of boundaries and barriers to current flow . The induced electric field can be predicted from the negative of the time-derivative of the vector potential field using Finite Element Method packages such as Comsol®, but the computations are not easy for most clinical practitioners. Induced voltage gradients are also challenging to measure in the laboratory owing to electromagnetic interference from the high coil currents needed to produce the magnetic fields [23, 24].
In this context a mathematical modeling approach can be insightful. Many thinkers have been attracted to the complex and interesting problems of predicting the magnetic fields created by TMS coils of various shapes as well as predicting the induced electric fields in various anatomical models. Several quite elaborate models have been described [2, 15, 25] to predict magnetically induced eddy currents. These are based upon complex analytical treatments or upon finite element and finite difference models implemented by computer programs, some of which taking over an hour of computer time to execute  and most of which taking several tens of hours of human thinking time to fully comprehend. Once understood, such rigorous and detailed solutions for specific cases are not especially transportable or portable from one patient to the next or one biological application to the next.
For many relatively simple and clinically relevant geometries a compact analytical model could allow a more intuitive understanding of the influence of dominant parameters, based on the algebraic form of the final equation. Once derived, such an equation might well encapsulate much knowledge in compact notation and still be applicable to a large number of specific cases. This approach to understanding magnetic stimulation might be especially useful to clinicians not supported by a department of biomedical engineering that is capable of numerical modeling of many individual patients.
Thus the field of magnetic neural stimulation could benefit from a relatively straightforward, working theory that provides a way to visualize the three dimensional distribution of neurons that will be stimulated by a specified external coil—in other words, a pattern that tells the user how to aim the coil to stimulate a particular set of targets, including peripheral nerves, brain cortical regions, or even deeper brain structures, including if possible the directions of the nerve fibers in space that are likely to be activated. Such a simple, working scheme for visualization is not out of reach. The general features of magnetically induced voltage gradients, sufficient for modeling the physiology of nerve stimulation, can be calculated analytically because of the circular symmetry of the problem in a relatively uniform volume conductor like brain tissue. Simple boundary conditions, such as a flat or gently curved insulating surface and unlimited depth and width can be utilized . Such conditions apply to brain covered by layers of skin, skull, and cerebrospinal fluid, or peripheral nerves covered by flat skin and subcutaneous tissue. Here the mathematics of electromagnetism and the mathematics of nerve impulse generation can be combined to create an analytical model of magnetic stimulation of brain and nerves that is sufficiently accurate for medical and biological applications, yet is mathematically compact, three dimensional, and easy to visualize.
This paper presents a fresh, clean-sheet analysis along these lines to clarify the underlying physics and to answer the following questions. How do magnetic fields stimulate nerve cells? What parts of the neuron are depolarized sufficiently by magnetic stimulation to generate an action potential? Where are the zones of stimulation located in the field beneath the exciting coils? How deep can stimulation be achieved for a given coil geometry? How does the spatial orientation of the nerve fiber tracts influence the ability of nerve fibers to be stimulated? How might the use of figure of eight coil configurations better target particular brain regions for focal stimulation?
The approach followed here is to begin with first principles (1) to describe the physics by which electric currents and voltages are produced in tissue by magnetic fields and then (2) to explore the mechanisms by which action potentials are subsequently initiated in neurons. The goal is to predict the approximate three dimensional patters of magnetically induced voltage and current and also to predict in terms of easily measured variables the target volume of space in which neurons are brought from their resting membrane potential to the threshold membrane potential for initiation of action potentials.
Part one: quantitative estimates of magnetically induced electric fields
Electromagnetism and electromagnetic induction
Regression constants describing radii at which axial field strength falls to zero
Magnetic field strength
Maximal z-axis component of magnetic field
Specific membrane capacitance of nerve cells
Vector of magnetically induced electric field
Signed scalar magnitude of induced electric field around a circular path in homogeneous models
Scalar component of the voltage gradient along the path of an axon
Change in transmembrane potential of an axon
Maximum coil current in time
Length of an axon segment
Magnetic permeability of free space
Number of coil turns or fold-increase in coil current
Radial distance from z-axis in space
Normalized radial distance, r/R
Resistance of axoplasm
Resistivity of intracellular fluid
Surface area for magnetic flux
Span or width of cell
Angle between induced electric field and an axon segment
|ΔV L |
Absolute value of voltage appearing along the length, L, of axon
x, y, z
Spatial coordinates normalized by coil radius, R
Radial distance from z-axis at which axial component of magnetic field becomes zero
At any particular depth, z, the magnetic field has axial and radial components, Bz(z, r) and Br(z, r), sketched approximately in Figure 2 to show relative shapes and strengths. Of note are the radii r0, at which the axial field strength falls to zero. The values of r0 increase gradually as a function of depth, z. As distance, z, from the plane of the coil increases, the z-directed components of the magnetic field spread out and diminish in intensity.
Induced electric fields in homogeneous underlying tissues
where the integral is taken over the area bordered by the closed path . In Figure 1 when the current, I, in the coil changes rapidly, the induced magnetic field components Bz are normal to the x-y plane and correspond to Bn in Equation (2b).
Measuring EMF induced by a rapidly changing magnetic field using a search coil in a dry laboratory is a straightforward task. One simply fashions a small loop of insulated wire about 1 cm in diameter and measures the voltage appearing between the ends of the wire. By tilting the plane of the coil one can find the direction of the field. In a volume conductor, however, the induced currents are constrained by insulated boundaries, and some further insight is required.
Radial components of the B-field can be ignored
Estimating z-axis components of the B field
Approximating the dome shaped function Bz(z, r) as the parabola , in keeping with more detailed and exact computations [13, 22], one can take advantage of the circular symmetry of the problem to find the total magnetic flux through circles of any radius, 0 ≤ r ≤ r0, centered along the z-axis and perpendicular to it. This approximation greatly simplifies the calculation of magnetic and induced electric fields and is sufficiently accurate for the purpose of understanding the biological response to magnetic stimulation. If desired, the parabolic representation of Bz(z, r) can be expanded to a higher order polynomial in r for any desired degree of accuracy. The following approach to integration will still be valid.
where Bz(z,0) is given by Equation (1a). For radii r > r0 one can estimate the magnetic flux through a loop of electrical conductor with radius r as Φ(z, r) = Φ(z, r 0), ignoring low amplitude reversed flux at outer radii, which are outside the region of interest in magnetic stimulation. (Alternatively, a higher order polynomial can be used.) In this way the magnetic flux through a circular domain of the volume conductor with radius r can be estimated from the peak on-axis value in Equation (1), multiplied by the area of the circle and the attenuation factor in parentheses in Equation (5b).
For example, one can compute the magnitude of induced EMF caused by a typical magnetic pulse, for which in practical units the maximal current output Imax ≈ 10,000 amperes, Δt ≈ 100 microseconds, giving dI/dt ≈ 108 A/sec , with the magnetic permeability constant, μ0 = 4π × 10−7 V · sec /(A · m). Current in the coil is typically produced by repeated capacitor discharges, which are damped by the inductance of the coil and opposed also by the small coil resistance. In such a discharge circuit the current rises quickly to a maximal level and then decays quickly  the rise time Δt1 is on the order of 100 microseconds and the fall time Δt2 is on the order of 200 microseconds , leading to reasonable estimates of (dI/dt).
Figure 5 shows the predicted strength of the magnetic field in Volts/meter given by Equations (7c) and (7d). The induced voltage gradients and eddy currents flow parallel to the surface in circles concentric with the coil, and opposite in direction to the direction of current increase in the coil, as expected from Faraday’s Law. In this simple system there are no insulating boundaries that obstruct current flow and no accumulation of surface charge at insulating boundaries . The resistivity of the tissue of the volume conductor in this model is also homogeneous. The results are quite similar to those reported by Roth and Basser  and by Tofts  using much more elaborate methods.
The direction of E depends on the direction of current flow in the coil and also on whether the current is increasing or decreasing. If the B-field is rising to its maximal value the induced EMF will be negative in the sense of the right hand rule and Equation (6). When the B-field is falling from its maximal value the direction of the induced EMF will be reversed. The results in Figure 5 are for a single coil with a single turn. For multi-turn coils the current derivative term (dI/dt) is multiplied by the number of turns. As explained subsequently, the same approach can be applied to double figure of eight coils by doubling the induced field in the region of overlap.
Part two: interaction of neurons with induced electric fields
Neuron anatomy and physiology
Anatomically typical nerve cells, or neurons, are most unusually shaped, having a cell body at one end that is perhaps 25 micrometers in diameter and a very long, thin arm or projection of membrane covered cytoplasm known as the axon that is roughly one micron in diameter and can span distances of one thousand to one million micrometers in some cases . Excitation of a nerve cell means the initiation of a self-propagating wave of depolarization known as an action potential, usually starting at one end near the cell body and continuing at speeds of several meters per second down the length of the axon. This special anatomy and physiology allows neurons to send signals at high speed over macroscopic distances from one part of the body to another .
Normal neurons are polarized in the resting state by a charge difference across the outer membrane of the cell of (inside negative, outside positive) of approximately −85 mV . In order for an action potential to be generated the transmembrane potential at a particular site on the surface of the cell must be brought from the resting level of −85 mV to a threshold level near −55 mV, at which voltage sensitive sodium channels in the membrane open to allow depolarizing current to flow in the form of charged Na+ ions. This current eliminates the transmembrane charge difference locally and triggers depolarization of adjacent membrane, sending a propagated signal along the length of the axon .
Cell bodies are not stimulated directly
The full magnitude of the potential appearing across the cell, however, is not significant physiologically. In the case of Figure 5, taking the maximal gradient as 25 V/m, the total voltage developed across the cell is only 25 μV/μm × 25 μm = 625 μV or 0.6 mV, a far cry from the 30 or so mV needed to depolarize one side of the cell from the resting membrane potential to the threshold potential. This same reasoning also applies to larger cell bodies, like pyramidal cells in the brain. In the same vein it is obvious that electric fields that appear at right angles to axons in nerve fiber tracts cannot induce a threshold membrane potential change, since the diameters of axons are on the order of only 1 micrometer. This conclusion agrees with the prior work of Nowak and coworkers [34, 35].
Axons spanning several millimeters are the sites of magnetic stimulation
where E L is the scalar component of the electric field along the path of the axon, and points P1 and P2 are points where the axon enters and exits the induced voltage field. In this scenario ± 0.5 ΔVL will appear very quickly across the axonal membrane segments at P1 and P2.
or about 2.4 microseconds. This means that after about 5 microseconds the membrane sections are almost fully charged and the whole voltage gradient appears between the ends of a myelinated axon segment. Since the rise or fall times, Δt, for magnetic pulses are approximately 100 microseconds long, there is plenty of time to charge the membranes of myelinated axons, as well as non-myelinated ones, to the full gradient potential, ΔVL, created by magnetic induction.
Figure of eight coils
Helpful reinforcing effects are possible in simple cases without severely restricting lateral boundaries. In a semi-infinite space a double torus of induced voltage and current is created. As the absolute intensities of the paired Bz-fields rise and fall in time there are counter rotating induced currents that can combine and reinforce the voltage gradient near the common z-axis. As coil current rises and falls the heights of the bowls rise and fall. If current reverses direction, the bowls flip vertically. Parallel components of induced current near the z-axis add to reinforce each other. At a depth of one third to one half coil radius (see below) a sweet spot exists where induced voltage gradients are nearly double what they would have been at the same z-level for a single coil . In the far field the overlapping B-fields near the z-axis cancel, but only in the zone of overlap. Elsewhere around the circumferences of the individual loops of the figure of eight, circular symmetry prevails and eddy currents are still induced, as they would be for a single coil.
Axons running in many directions, but not directly parallel to the z-axis of an electromagnetic coil carrying rapidly changing current can be depolarized or hyperpolarized by induced electric fields at depths up to one coil diameter from the plane of the coil. Both myelinated and non-myelinated axons can be stimulated. The sites of greatest membrane depolarization are located toward the ends of the axon segments traversing the region of induced voltage and current. The target volume for magnetic stimulation takes the shape of a toroid centered along the z-axis with major radius similar to that of the current carrying coil and its minor radius varying in size, depending on the coil current. When figure of eight coils are used there is the opportunity to create spindle shaped target volumes of stimulation, centered on the z-axis at a depth of about one third to one half coil radius.
In the forgoing analytical treatment many simplifying assumptions have been introduced to make the mathematics more tractable and useful, realizing than in any particular biological experiment there is some lack of precision in specifying geometric distances and physiological conditions. Hence, only the most dominant terms in the mathematics need to be considered in a biologically satisfactory solution to the targeting problem. For example, the position of a coil in a clinical stimulation protocol can only be specified within about one millimeter. The thickness of a practical coil is on the order of several millimeters, perhaps better characterized as a bundle of one dimensional wire loops, blurring the idealized fields calculated for any single loop. The positions of underlying nerves and brain structures vary from subject to subject and typically cannot be known exactly in a particular treatment situation or experiment. Similarly, the intracellular and extracellular sodium and potassium ion concentrations that determine resting and threshold membrane potentials can vary among subjects, the intracellular values being especially hard to measure. Additionally there are motion artifacts, including subtle movement in time and space with breathing, fidgeting, as well as any muscle movement caused by nerve stimulation itself.
Accordingly, the positions of biologic structures with respect to magnetic and electric fields can only be specified within a millimeter or two at best. For such reasons over-precise prediction is a fool’s errand. What is more useful is the ability to predict within, say, 10 percent, the locations and directions of axons likely to be stimulated by a given practical apparatus, and especially the ability to visualize in three dimensions the locations and orientations of nerve axons likely to be stimulated by a given coil and current intensity. Equations (14a) and (14b) provide a compact, closed form solution for the effects of magnetic neurostimulation in terms of the dominant variables: the slew rate of coil current, the axial and radial distances of the target axon from the center of the coil, the length of the axon within the induced electric field, and the angle of the axon in space. This kind of predictive capability has not been available heretofore.
The theory presented here is validated by experimental observations. When using a single circular coil to stimulate the median nerve in the wrist, Maccabee et al.  found the most sensitive position for stimulation the nerve was located beneath the middle circumference of the coil in the position of maximal toroidal current. However when figure of eight coils were used, the most sensitive position for stimulation of the nerve was located at the midpoint between the two loops of the coil. Rudiak and Marg  used a clever approach to estimate the effective depth of magnetic brain stimulation in human subjects. For figure of eight coils with 10 cm diameter (5 cm radius) loops, the focal depth of stimulation was between 1.8 and 2.1 cm, or between 36% and 42% of coil radius, very close to that predicted by the present analysis (Figure 14).
Magnetic neural stimulation is a remarkable and subtle phenomenon, able to penetrate highly resistive skin and bone with ease and stimulate underlying nerve fibers. This paper presents a condensed synthesis of electromagnetic theory and cable theories of axon physiology to better inform further development and clinical practice of magnetic neurostimulation, including transcranial magnetic stimulation. With knowledge of the critical variables and a little imagination it is possible to visualize in three dimensions the best way to arrange and orient surface coils to achieve stimulation within a defined volume of underlying tissue.
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