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  1. Machine learning, especially deep learning, is becoming more and more relevant in research and development in the medical domain. For all the supervised deep learning applications, data is the most critical fa...

    Authors: Adrian Krenzer, Kevin Makowski, Amar Hekalo, Daniel Fitting, Joel Troya, Wolfram G. Zoller, Alexander Hann and Frank Puppe
    Citation: BioMedical Engineering OnLine 2022 21:33
  2. The current method to evaluate the autonomic balance after renal denervation (RDN) relies on heart rate variability (HRV). However, parameters of HRV were not always predictive of response to RDN. Therefore, t...

    Authors: Po-Lin Lin, Ping-Yen Lin, Han-Ping Huang, Hamideh Vaezi, Lawrence Yu-Min Liu, Ying-Hsiang Lee, Chun-Che Huang, Ten-Fang Yang, Long Hsu and Chang Francis Hsu
    Citation: BioMedical Engineering OnLine 2022 21:32
  3. The objective is to clarify the effect of alveolar cleft bone graft on maxillofacial biomechanical stabilities, the key areas when bone grafting and in which should be supplemented with bone graft once bone re...

    Authors: Tao Tian, Han-yao Huang, Wei Wang, Bing Shi, Qian Zheng and Cheng-hao Li
    Citation: BioMedical Engineering OnLine 2022 21:31
  4. Integrin, beta-like 1 (ITGBL1) is involved in a variety of human malignancies. However, the information on the involvement of ITGBL1 in gastric carcinoma (GC) is limited. Hence, this study aimed further to exp...

    Authors: Zhe Wang, Liu Fu, Junjie Zhang, Yanli Ge, Cheng Guo, Rui Wang, Min Deng, Qizhi Wang and Zhirong Wang
    Citation: BioMedical Engineering OnLine 2022 21:30
  5. Falls among older adults have become a global concern. While previous studies have established associations between autonomic function indicator; heart rate variability (HRV) and blood pressure variability (BP...

    Authors: Nur Husna Shahimi, Choon-Hian Goh, Sumaiyah Mat, Renly Lim, Vivian Ci Ai Koh, Samuel R. Nyman, Maw Pin Tan and Einly Lim
    Citation: BioMedical Engineering OnLine 2022 21:29
  6. Current ankle prostheses for people with unilateral transtibial amputation (TTA) or transfemoral amputation (TFA) are unable to mimic able-bodied performance during daily activities. A new mechanical ankle–foo...

    Authors: Elke Lathouwers, Toon Ampe, María Alejandra Díaz, Romain Meeusen and Kevin De Pauw
    Citation: BioMedical Engineering OnLine 2022 21:28
  7. Increasing attention has been paid to the potential relationship between gut and lung. The bacterial dysbiosis in respiratory tract and intestinal tract is related to inflammatory response and the progress of ...

    Authors: Zhendong Wang, Chen Bai, Tingyao Hu, Changyong Luo, He Yu, Xueyan Ma, Tiegang Liu and Xiaohong Gu
    Citation: BioMedical Engineering OnLine 2022 21:27
  8. Reflexive responses to head–neck perturbations affect the injury risk in many different situations ranging from sports-related impact to car accident scenarios. Although several experiments have been conducted...

    Authors: Isabell Wochner, Lennart V. Nölle, Oleksandr V. Martynenko and Syn Schmitt
    Citation: BioMedical Engineering OnLine 2022 21:25
  9. This study explored the feasibility of radiofrequency (RF)-based radiomics analysis techniques for the preoperative prediction of programmed cell death protein 1 (PD-1) in patients with hepatocellular carcinom...

    Authors: Qingmin Wang, Yi Dong, Tianlei Xiao, Shiquan Zhang, Jinhua Yu, Leyin Li, Qi Zhang, Yuanyuan Wang, Yang Xiao and Wenping Wang
    Citation: BioMedical Engineering OnLine 2022 21:24
  10. Due to the steadily increasing life expectancy of the population, the need for medical aids to maintain the previous quality of life is growing. The basis for independent mobility is a functional locomotor sys...

    Authors: Lena Risse, Steven Woodcock, Jan-Peter Brüggemann, Gunter Kullmer and Hans Albert Richard
    Citation: BioMedical Engineering OnLine 2022 21:23
  11. Shock advice algorithm plays a vital role in the detection of sudden cardiac arrests on electrocardiogram signals and hence, brings about survival improvement by delivering prompt defibrillation. The last deca...

    Authors: Minh Tuan Nguyen, Thu-Hang T. Nguyen and Hai-Chau Le
    Citation: BioMedical Engineering OnLine 2022 21:22
  12. Using embedded sensors, instrumented walkways provide clinicians with important information regarding gait disturbances. However, because raw data are summarized into standard gait variables, there may be some...

    Authors: Wenting Hu, Owen Combden, Xianta Jiang, Syamala Buragadda, Caitlin J. Newell, Maria C. Williams, Amber L. Critch and Michelle Ploughman
    Citation: BioMedical Engineering OnLine 2022 21:21
  13. Early diagnosis and continuous monitoring are the key to emergency treatment and intensive care of patients with acute ischemic stroke (AIS). Nevertheless, there has not been a fully accepted method targeting ...

    Authors: Gen Li, Shengtong Yin, Man Jian, Jingbo Chen, Lingxi Zeng, Zelin Bai, Wei Zhuang, Bingxin Xu, Shengjie He, Jian Sun and Yujie Chen
    Citation: BioMedical Engineering OnLine 2022 21:20
  14. Mental illness represents a major global burden of disease worldwide. It has been hypothesised that individuals with mental illness have greater blood pressure fluctuations that lead to increased cardiovascula...

    Authors: Nur Husna Shahimi, Renly Lim, Sumaiyah Mat, Choon-Hian Goh, Maw Pin Tan and Einly Lim
    Citation: BioMedical Engineering OnLine 2022 21:19
  15. This study aims to analyze the effects of a novel dual-bearing shoulder prosthesis and a conventional reverse shoulder prosthesis on the deltoid and rotator cuff muscle forces for four different arm motions. T...

    Authors: Bernhard Weisse, Susan Lama, Gabor Piskoty, Christian Affolter and Ameet K. Aiyangar
    Citation: BioMedical Engineering OnLine 2022 21:17
  16. Patient-specific lung mechanics during mechanical ventilation (MV) can be identified from measured waveforms of fully ventilated, sedated patients. However, asynchrony due to spontaneous breathing (SB) effort ...

    Authors: Cong Zhou, J. Geoffrey Chase, Qianhui Sun, Jennifer Knopp, Merryn H. Tawhai, Thomas Desaive, Knut Möller, Geoffrey M. Shaw, Yeong Shiong Chiew and Balazs Benyo
    Citation: BioMedical Engineering OnLine 2022 21:16
  17. Age-related changes in muscle properties affect daily functioning, therefore a reliable assessment of such properties is required. We examined the effects of age on reliability, muscle quality and interrelatio...

    Authors: Iris Hagoort, Tibor Hortobágyi, Nicolas Vuillerme, Claudine J. C. Lamoth and Alessio Murgia
    Citation: BioMedical Engineering OnLine 2022 21:15
  18. The role of high-frequency oscillatory ventilation (HFOV) has long been debated. Numerous studies documented its benefits, whereas several more recent studies did not prove superiority of HFOV over protective ...

    Authors: Karel Roubík, Jakub Ráfl, Martin Rožánek, Petr Kudrna and Mikuláš Mlček
    Citation: BioMedical Engineering OnLine 2022 21:14
  19. Mechanical ventilation (MV) is the primary form of care for respiratory failure patients. MV settings are based on general clinical guidelines, intuition, and experience. This approach is not patient-specific ...

    Authors: Jay Wing Wai Lee, Yeong Shiong Chiew, Xin Wang, Mohd Basri Mat Nor, J. Geoffrey Chase and Thomas Desaive
    Citation: BioMedical Engineering OnLine 2022 21:13
  20. Gastric disease is a major health problem worldwide. Gastroscopy is the main method and the gold standard used to screen and diagnose many gastric diseases. However, several factors, such as the experience and...

    Authors: Ziyi Jin, Tianyuan Gan, Peng Wang, Zuoming Fu, Chongan Zhang, Qinglai Yan, Xueyong Zheng, Xiao Liang and Xuesong Ye
    Citation: BioMedical Engineering OnLine 2022 21:12
  21. The study aims at solving the problem with the limitations of the homecare CPAP equipment such as sleep apnea devices in the treatment of COVID-19 pneumonia. By adding an advanced, rapid-to-produce oxygenation...

    Authors: Dmitrijs Bliznuks, Svjatoslavs Kistkins, Jevgēnijs Teličko, Vadims Geža, Ģirts Zāģeris, Artis Svaža, Emil Syundyukov, Mārtiņš Purenkovs, Dana Zeme, Solveiga Jēkabsone, Dace Žentiņa, Valdis Pīrāgs and Immanuels Taivans
    Citation: BioMedical Engineering OnLine 2022 21:10
  22. Mental workload is a critical consideration in complex man–machine systems design. Among various mental workload detection techniques, multimodal detection techniques integrating electroencephalogram (EEG) and...

    Authors: Hongzuo Chu, Yong Cao, Jin Jiang, Jiehong Yang, Mengyin Huang, Qijie Li, Changhua Jiang and Xuejun Jiao
    Citation: BioMedical Engineering OnLine 2022 21:9
  23. The delay between amputation and prosthesis fitting contributes to the high rate of prosthetic abandonment despite advances in technology. Three-dimensional (3D) printing has allowed for the rapid fabrication ...

    Authors: Christopher Copeland, Claudia Cortes Reyes, Jean L. Peck, Rakesh Srivastava and Jorge M. Zuniga
    Citation: BioMedical Engineering OnLine 2022 21:7
  24. Menopause-induced decline in estrogen levels in women is a main factor leading to osteoporosis. The objective of this study was to investigate the effect of intermittent parathyroid hormone (PTH) on bone struc...

    Authors: Shun-Ping Wang, Ying-Ju Chen, Cheng-En Hsu, Yung-Cheng Chiu, Ming-Tzu Tsai and Jui-Ting Hsu
    Citation: BioMedical Engineering OnLine 2022 21:6
  25. Systems aiding in selecting the correct settings for mechanical ventilation should visualize patient information at an appropriate level of complexity, so as to reduce information overload and to make reasonin...

    Authors: Stephen Edward Rees, Savino Spadaro, Francesca Dalla Corte, Nilanjan Dey, Jakob Bredal Brohus, Gaetano Scaramuzzo, David Lodahl, Robert Ravnholt Winding, Carlo Alberto Volta and Dan Stieper Karbing
    Citation: BioMedical Engineering OnLine 2022 21:5
  26. Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation of the epidemiological c...

    Authors: Yiyi Yao, Xiangjie Lin, Fenglin Li, Jie Jin and Huafeng Wang
    Citation: BioMedical Engineering OnLine 2022 21:4
  27. Demographic change is leading to an increase in the number of osteoporotic patients, so a rethink is required in implantology in order to be able to guarantee adequate anchoring stability in the bone. The func...

    Authors: Isabell Hamann, Stefan Schleifenbaum, Christian Rotsch, Welf-Guntram Drossel, Christoph-Eckhard Heyde and Mario Leimert
    Citation: BioMedical Engineering OnLine 2022 21:3
  28. The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long noncoding RNAs (lncRNAs) govern a variety of biological processes, such as EMT...

    Authors: Zhixiong Chen, Xi Chu and Jinghong Xu
    Citation: BioMedical Engineering OnLine 2022 21:2

    The Correction to this article has been published in BioMedical Engineering OnLine 2023 22:86

  29. Excessive aggregation of β-amyloid peptides (Aβ) is regarded as the hallmark of Alzheimer’s disease. Exploring the underlying mechanism regulating Aβ aggregation remains challenging and investigating aggregati...

    Authors: Yang Xie, Lin Yu, Yuna Fu, Heng Sun and Jianhua Wang
    Citation: BioMedical Engineering OnLine 2021 20:132
  30. Image registration is an essential step in the automated interpretation of the brain computed tomography (CT) images of patients with acute cerebrovascular disease (ACVD). However, performing brain CT registra...

    Authors: Hongmei Yuan, Minglei Yang, Shan Qian, Wenxin Wang, Xiaotian Jia and Feng Huang
    Citation: BioMedical Engineering OnLine 2021 20:131
  31. Ankle sprain affects the structure and function of ankle cartilage. However, it is not clear whether the daily training and competition affect the ankle cartilage without acute injury. Changes in ankle cartila...

    Authors: Sipin Luo, Yi Cao, Peng Hu, Nan Wang and Yeda Wan
    Citation: BioMedical Engineering OnLine 2021 20:130
  32. Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRN...

    Authors: Shumin Xie, Li Jin, Tuanfang Yin, Jihao Ren and Wei Liu
    Citation: BioMedical Engineering OnLine 2021 20:129
  33. Wogonin (5, 7-dihydroxy-8-methoxyflavone) is a natural di-hydroxyl flavonoid extracted from the root of Scutellaria baicalensis Georgi. This paper was intended to investigate the mechanism of action of wogonin in...

    Authors: Jinlin Ge, Huanhuan Yang, Yufeng Zeng and Yunjie Liu
    Citation: BioMedical Engineering OnLine 2021 20:125
  34. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) is the most sensitive technique for evaluating gene expression levels. Choosing appropriate reference genes (RGs) is critical for normaliz...

    Authors: Qiang Song, Lu Dou, Wenjin Zhang, Yang Peng, Man Huang and Mengyuan Wang
    Citation: BioMedical Engineering OnLine 2021 20:124
  35. The COVID-19 disease is putting unprecedented pressure on the global healthcare system. The CT (computed tomography) examination as a auxiliary confirmed diagnostic method can help clinicians quickly detect le...

    Authors: Wei Li, Yangyong Cao, Kun Yu, Yibo Cai, Feng Huang, Minglei Yang and Weidong Xie
    Citation: BioMedical Engineering OnLine 2021 20:123
  36. Heart rate (HR) is an important vital sign for evaluating the physiological condition of a newborn infant. Recently, for measuring HR, novel RGB camera-based non-contact techniques have demonstrated their specifi...

    Authors: Qiong Chen, Yalin Wang, Xiangyu Liu, Xi Long, Bin Yin, Chen Chen and Wei Chen
    Citation: BioMedical Engineering OnLine 2021 20:122
  37. Automated tools for landmarking the internal carotid artery (ICA) bends have the potential for efficient and objective medical image-based morphometric analysis. The two existing algorithms rely on numerical a...

    Authors: Henrik A Kjeldsberg, Aslak W Bergersen and Kristian Valen-Sendstad
    Citation: BioMedical Engineering OnLine 2021 20:120
  38. Long-leg-radiography (LLR) is commonly used for the measurement of lower limb alignment. However, limb rotations during radiography may interfere with the alignment measurement. This study examines the effect ...

    Authors: Xiaoshu Sun, Bin Yang, Shengzhao Xiao, Yichen Yan, Zifan Liu, Liang Yuan, Xiaohua Wang, Bin Sun, Jie Yao and Yubo Fan
    Citation: BioMedical Engineering OnLine 2021 20:119
  39. Running on sand could be a promising exercise intervention for the treatment of over-pronated feet. However, there is a lack of knowledge about the effects of running on sand on muscle activities. Therefore, t...

    Authors: AmirAli Jafarnezhadgero, Amir Fatollahi, Ali Sheykholeslami, Valdeci Carlos Dionisio and Mohammad Akrami
    Citation: BioMedical Engineering OnLine 2021 20:118
  40. Large bone defects have always been a great challenge for orthopedic surgeons. The use of a good bone substitute obtained by bone tissue engineering (BTE) may be an effective treatment method. Artificial hydro...

    Authors: Chengyong Li, Tingting Yan, Zhenkai Lou, Zhimin Jiang, Zhi Shi, Qinghua Chen, Zhiqiang Gong and Bing Wang
    Citation: BioMedical Engineering OnLine 2021 20:116
  41. Nanomaterials of biomedicine and tissue engineering have been proposed for the treatment of periodontitis in recent years. This study aimed to investigate the effects of gold nanoparticles (AuNPs) combined wit...

    Authors: Jing Zhou, Lingjun Li, Di Cui, Xiaoting Xie, Wenrong Yang and Fuhua Yan
    Citation: BioMedical Engineering OnLine 2021 20:115