Table 4 Intestine–liver chip

Caco-2^a, HepG2

Predict oral drug administration and in vitro first pass metabolism, simulate ethanol first pass metabolism

[38]

HepG2

Study the EVs of microbiota and the interaction between microbiota and host cells

[39]

Caco-2^a, HCs, HT29^b

Study the PK of mycophenolate ester and its two main metabolites

[40]

Caco-2, HepG2

Consist of four microfluidic structures (cell culture layer, porous membrane, circulation layer, and control layer). Allow independent physiological perfusion of each organ in the cell culture chamber for disease modeling

[41]