Table 3 LOC for hepatotoxicity study

HCs, LSECs

Simulate the structure of liver acini and induce liver partitioning. Improve resistance to acetaminophen toxicity for liver toxicity testing

[33]

HLCs, HUVECs, HHSCs

Use squeeze bioprinting technology to establish for DILI liver toxicity testing

[34]

HUVEC, HepaRG^a

Simulate hepatic sinus, use 3D dynamic multi-cell co-culture for in vitro hepatotoxicity screening

[35]

HCs

Use for liver toxicity detection of nanoparticle SPION and screen for drug-induced partitioned liver toxicity

[36]

HepG2, HUVECs, HFF-1

Use chip technology, microporous arrays, and cell microspheres. Uniform microspheres and microporous arrays divide the traditional “single pot” analysis unit into hundreds of independent analysis sheets

[37]