Table 2 LOC for disease modeling and drug screening
From: Construction of in vitro liver-on-a-chip models and application progress
Picture | Cell type | Description | References |
|---|---|---|---|
| Huh-7 | It combines COC with PDMS and can be used for screening and cell analysis of lipid intermediates. It is also suitable for rapid prototyping and cultivate functional liver cancer Huh-7 cell lines | [7] |
| hiPSCs | This chip combines stem cell organoids with organ chip technology and is established using a hiPSC-derived liver organoid chip system | [29] |
| HepaRGa LX2 cellsb | For the detection of NAFLD. The changes of lipid partition in hepatic lobules with the progress of NAFLD were proved at chip level | [30] |
| iHep, iEndo | It was prepared using the innovative equipment MINERVA 2.0. Evaluation of the drug donepezil for Alzheimer 's disease and screening for hepatotoxicity | [31] |
| HepG2 | It is used to study the anti-cancer effects of statins and their metabolites | [32] |
