Table 1 LOC established based on liver structure, zoning, and cell type
From: Construction of in vitro liver-on-a-chip models and application progress
Picture | Cell type | Description | References |
|---|---|---|---|
| HepG2 | Four chips (each chip containing two chambers) are connected in series to form eight interconnected chambers. Hypoxia gradient is produced in vitro, simulating the hepatic acinar. For in vitro analysis in normoxic to hypoxia gradient | [24] |
| HCs、HSCs、LSECs | A three-vessel liver chip composed of hepatic artery, portal vein, and central vein is used to reconstruct hepatic lobules in vitro. To drug hepatotoxicity, metabolism, and in vitro tumor invasion mechanisms | [25] |
| HSCs、KCs、LSECs | Simulate the liver hardness of normal or cirrhosis, revealing the vascular properties of TME during cancer and the tumor's response to drugs | [26] |
| HSCs、 hMSCs、HepG2 | A model for detecting the fusion and invasion mechanisms of HepG2 with hMSCs and HSCs cells in TME | [27] |
| HSCs | To study the behavior and TME of HSCs in liver tumor matrix and observe the migration behavior of HSCs under different conditions and the effect of TGF-β1 on its migration | [28] |
