Fig. 5From: Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cellsUpregulation of CUL3 expression combined with activation of SHH signaling alleviated vascular injury of hypertension mouse model induced by Ang II. A, B Measurement of Systolic blood pressure (SBP) and diastolic blood pressure (DBP) at D14 and D28 following insertion of Ang II osmotic pumps by using a tail-cuff blood pressure instrument. C The pathological changes of abdominal aortic tissues were evaluated with H&E staining. Magnification, × 200. The levels of D NO, E ROS and F SOD were examined with the corresponding commercial available kit. ***P < 0.001 vs. normal; ###P < 0.001 vs. model; △P < 0.05, △△△P < 0.001 vs. model + NC + SAGBack to article page