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Fig. 5 | BioMedical Engineering OnLine

Fig. 5

From: Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

Fig. 5

Upregulation of CUL3 expression combined with activation of SHH signaling alleviated vascular injury of hypertension mouse model induced by Ang II. A, B Measurement of Systolic blood pressure (SBP) and diastolic blood pressure (DBP) at D14 and D28 following insertion of Ang II osmotic pumps by using a tail-cuff blood pressure instrument. C The pathological changes of abdominal aortic tissues were evaluated with H&E staining. Magnification, × 200. The levels of D NO, E ROS and F SOD were examined with the corresponding commercial available kit. ***P < 0.001 vs. normal; ###P < 0.001 vs. model; P < 0.05, P < 0.001 vs. model + NC + SAG

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