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Table 3 The DALY of CLL in 1990 and 2019 and its temporal trends

From: The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019

 

1990

2019

1990–2019

DALY cases

No*102 (95% CI)

Age-standardized DALY rate/100,000

No. (95% CI)

DALY cases

No*102 (95% CI)

Age-standardized DALY rate /100,000

No. (95% CI)

EAPC

No. (95% CI)

Overall

4920.75 (4452.50–5322.84)

9.20 (8.32–9.95)

9484.64 (8741.97–10,652.54)

12.26 (11.30–13.77)

0.92 (0.90–0.94)

Sex

     

 Male

2620.91 (2263.04–2864.75)

9.73 (8.40–10.63)

4858.99 (4363.26–5723.79)

12.52 (11.24–14.75)

0.85 (0.83–0.87)

 Female

2299.84 (2055.07–2577.62)

8.66 (7.74–9.70)

4625.65 (4120.79–5275.03)

11.99 (10.69–13.68)

1.01 (0.99–1.03)

Socio-demographic factor

     

 High SDI

1944.55 (1776.26–2089.29)

23.66 (21.61–25.42)

2632.63 (2353.15–3229.85)

25.98 (23.22–31.87)

0.06 (0.04–0.07)

 High-middle SDI

1402.98 (1248.66–1554.35)

12.20 (10.85–13.51)

2545.13 (2341.45–2840.04)

17.79 (16.37–19.85)

1.26 (1.24–1.27)

 Middle SDI

734.69 (597.50–867.40)

4.28 (348–5.05)

2033.96 (1805.27–2342.81)

8.49 (7.53–9.78)

2.64 (2.62–2.67)

 Low-middle SDI

569.47 (479.14–679.76)

5.04 (4.24–6.02)

1555.53 (1345.94–1816.49)

8.82 (7.63–10.30)

1.93 (1.90–1.95)

 Low SDI

266.93 (210.66–325.61)

5.05 (3.99–6.17)

713.44 (59.46–834.46)

6.32 (5.29–7.39)

0.77 (0.74–0.80)

Region

     

 Andean Latin America

8.65 (7.05–10.96)

2.27 (1.85–2.87)

30.46 (23.15–38.63)

4.79 (3.64–6.07)

2.82 (2.78–2.86)

 Australasia

48.97 (44.43–57.37)

24.15 (21.91–28.29)

85.41 (72.99–106.85)

29.39 (25.11–36.76)

0.35 (0.34–0.36)

 Caribbean

23.04 (20.49–25.55)

6.53 (5.81–7.24)

43.37 (36.26–51.76)

9.20 (7.69–10.97)

1.22 (1.20–1.25)

 Central Asia

48.80 (40.69–55.21)

7.04 (5.88–7.97)

72.53 (60.94–88.87)

7.75 (6.52–9.50)

0.11 (0.08–0.13)

 Central Europe

237.03 (213.69–284.28)

19.28 (17.38–23.12)

533.43 (453.28–643.32)

46.70 (39.68–56.32)

3.30 (3.29–3.31)

 Central Latin America

45.64 (40.66–48.47)

2.78 (2.48–2.95)

126.43 (104.93–155.05)

5.06 (4.20–6.20)

2.00 (1.96–2.03)

 Central Sub-Saharan Africa

15.34 (10.57–23.11)

2.76 (1.90–4.16)

68.29 (45.39–99.00)

5.19 (3.45–7.53)

2.34 (2.30–2.37)

 East Asia

520.51 (383.84–700.76)

4.25 (3.13–5.72)

1501.93 (1249.41–1826.59)

10.20 (8.49–12.41)

3.69 (3.66–3.72)

 Eastern Europe

572.17 (457.99–677.76)

25.26 (20.22–29.92)

734.59 (642.27–832.19)

34.99 (30.59–39.63)

0.90 (0.89–0.91)

 Eastern Sub-Saharan Africa

97.46 (74.45–124.07)

5.12 (3.92–6.52)

265.68 (216.60–332.14)

6.45 (5.26–8.07)

0.86 (0.83–0.88)

 High-income Asia Pacific

44.68 (41.66–54.63)

2.57 (2.40–3.15)

75.89 (64.80–93.91)

4.05 (3.46–5.01)

1.56 (1.3–1.60)

 High-income North America

882.94 (793.23–938.53)

31.43 (28.24–33.41)

1181.33 (1059.13–1444.17)

32.40 (29.05–39.61)

− 0.34 (− 0.32–0.35)

 North Africa and Middle East

154.10 (118.40–191.88)

4.47 (3.43–5.56)

393.18 (329.89–465.10)

6.46 (5.42–7.64)

1.17 (1.15–1.20)

 Oceania

0.55 (0.40–0.73)

0.85 (0.62–1.13)

1.21 (0.86–1.70)

0.91 (0.65–1.28)

0.13 (0.05–0.20)

 South Asia

638.87 (529.44–766.80)

5.82 (4.82–6.99)

1826.08 (1549.90–2178.30)

10.12 (8.59–12.07)

1.83 (1.81–1.86)

 Southeast Asia

95.06 (79.00–116.84)

2.04 (1.69–2.50)

290.03 (238.18–364.78)

4.30 (3.53–5.41)

2.58 (2.54–2.61)

 Southern Latin America

44.39 (38.59–50.01)

8.96 (7.79–10.09)

67.59 (59.68–80.02)

10.13 (8.94–11.99)

− 0.01 (− 0.03–0.02)

 Southern Sub-Saharan Africa

84.00 (72.20–95.27)

16.00 (13.75–18.15)

170.79 (146.70–196.15)

21.74 (18.67–24.96)

1.29 (1.27–1.30)

 Tropical Latin America

61.89 (56.85–66.36)

4.05 (3.72–4.34)

169.91 (152.08–199.02)

7.60 (6.80–8.90)

2.28 (2.25–2.31)

 Western Europe

1201.95 (1103.38–1289.05)

31.25 (28.69–33.52)

1615.22 (1433.69–1939.40)

37.02 (32.86–44.45)

0.40 (0.38–0.41)

 Western Sub-Saharan Africa

94.70 (78.04–111.70)

4.92 (4.05–5.80)

231.27 (185.09–277.07)

5.07 (4.06–6.07)

0.12 (0.09–0.15)

  1. CLL, chronic lymphocytic leukemia; DALY, disability adjusted life-year; EAPC, estimated annual percentage changes; SDI, social-demographic index