Fig. 1

Effects of extractive media on cell survival. Survival rates of L-929 (a, b) and R28 (c, d) cells were analyzed in cultures incubated with increasing dilutions (1:1, 1:2, 1:4) of extractive media obtained from certified positive (RM A, RM B) and negative (RM C) reference materials as well as from negative (glass) controls and from the test structures; a, c flexible polyimide base; b, d sensor chip. The dotted lines designate mean values of the glass approaches (negative control). The results were compared to glass. Bars were calculated as mean ± SD. One-way ANOVA with Dunnett’s post hoc test was performed; **p < 0.01, ***p < 0.001, ****p < 0.0001. Flexible polyimide base: for L-929 cells: n = 4 individual experiments, for R28 cells: n = 6. Sensor chips: for L-929 and R28 cells: n = 8