Fig. 5

Celastrol inhibits the proliferation and invasion of HG-induced hRECs by down-regulating the HIF1α/VEGF signaling pathway. A The protein expression of HIF-1α and VEGF in HG-induced hRECs treated with DMOG and celastrol was detected by Western blot analysis. B The proliferation of HG-induced hRECs treated with DMOG and celastrol was observed by MTT assay. C The invasion of HG-induced hRECs treated with DMOG and celastrol was observed by Transwell assay. D Optical micrographs of invasion of HG-induced hRECs treated with DMOG and celastrol. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. NG group. ^##P < 0.01 and ^###P < 0.001 vs. HG group. ^∆P < 0.05 and ^∆∆∆P < 0.001 vs. HG + cela group. Cela: celastrol