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Table 9 Area under the receiving operator curve (mean and 95% confidence interval) of the traditional FOT parameters in the identification of the bronchodilator response in patients with work-related asthma

From: Combined forced oscillation and fractional-order modeling in patients with work-related asthma: a case–control study analyzing respiratory biomechanics and diagnostic accuracy

  AUC Se (%) Sp (%) Cut-off
R0 0.699
0.570–0.829
74.1
55.4–88.1
58.0
39.1–75.5
> 2.72
Rm 0.694
0.563–0.825
83.8
66.3–94.5
51.6
33.1–69.8
> 2.39
R4 0.708
0.580–0.835
93.5
78.6–99.2
38.7
21.8–57.8
> 2.00
R12 0.690
0.558–0.822
64.5
45.4–80.8
70.9
52.0–85.8
> 2.46
R20 0.691
0.558–0.824
74.1
55.4–88.1
61.2
42.2–78.2
> 2.20
S 0.686
0.554–0.817
77.4
58.9–90.4
51.61
33.1–69.8
≤ − 19.9
R4 − R20 0.677
0.542–0.813
61.2
42.2–78.2
70.9
52.0–85.8
> 0.30
Xm 0.629
0.489–0.768
45.1
27.3–64.0
87.1
70.2–96.4
≤ − 0.35
Fr 0.634
0.494–0.773
51.6
33.1–69.8
77.4
58.9–90.4
> 19.5
Cdyn 0.706
0.574–0.837
58.0
39.1–75.5
87.1
70.2–96.4
≤ 14.3
Axt 0.697
0.566–0.828
51.6
33.1–69.8
83.8
66.3–94.5
> 18.6
Axi 0.665
0.530–0.800
61.29
42.2 – 78.2
64.52
45.4 – 80.8
≤ 9.10
Z4 0.726
0.601–0.851
74.1
55.4–88.1
61.2
42.2–78.2
> 3.36
  1. Values considered adequate are described in italic
  2. AUC: area under the receiver operating curve; Se: sensitivity; Sp: specificity; R0: intercept resistance; Rm: mean resistance; S: slope of the resistive values; R4: resistance in 4 Hz; R12: resistance in 12 Hz; R20: resistance in 20 Hz; Xm: mean reactance; Fr: resonance frequency; Cdyn: dynamic compliance; Axt: area under the reactance curve using the approximation by a triangle; Axi: area under the reactance curve using the integral based on the trapezoidal rule; Z4: impedance modulus in 4 Hz