Fig. 5
Examples of electromyographic records of the average from four consecutive blink reflex responses of a Patient #1: a male patient (60 years, 65 kg), and b Patient #2: a female patient (47 years, 64 kg) who participated in this study. Each row shows the effects of the increasing administration of propofol. In Patient #1, after 117 s of propofol infusion, the R2 component disappeared. R1 component was last seen after 126 s, loss of responsiveness (aRASS = − 5) occurred after 135 s after propofol infusion, at an effect-site concentration of 3.93 µ/mL. In Patient #2, after 98 s of propofol infusion, the R2 component disappeared. R1 component was last seen after 113 s, loss of responsiveness (aRASS = -5) occurred after 134 s after propofol infusion, at an effect-site concentration of 3.00 µ/mL