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Table 1 Data extracted from ex vivo SD studies

From: Characterization of moderate tendinopathy in ex vivo stress-deprived rat tail tendons

References Model Culture duration Results
Short-term SD (early tendinopathy)
 Arnoczky et al. [5] Rat, adult, tail tendon 1, 2, 3 days Biomechanical
No change in maximum stress
Histological
Cell roundness
Immunohistochemistry
Increase in MMP-13 expression
 Egerbacher et al. [6] Rat, adult, tail tendon 24 h Biomechanical
N/A
Histological
Decrease in collagen fiber density
Immunohistochemistry
Increase in MMP-13 expression and MMP-13 protein synthesis
Egerbacher et al. [42] Rat, adult, tail tendon 24 h Biomechanical
N/A
Histological
Increase in cell apoptosis
Immunohistochemistry
N/A
Gardner et al. [7] Rat, 6 months old, tail tendon 24, 48, 72 h Biomechanical
N/A
Histological
N/A
Immunohistochemistry
Increase in MMP-13 expression
Long-term SD (advanced tendinopathy)
 Abreu et al. [9] Rat, male, adult, tail tendon 1 week Biomechanical
Decrease in elastic modulus
Histological
N/A
Immunohistochemistry
Decrease in GAGa content
 Arnoczky et al. [10] Rat, adult, tail tendon 7 days Biomechanical
Decrease in ultimate stress, tensile
modulus and strain at ultimate stress
Histological
Less dense collagen fiber packing
Immunohistochemistry
Increase in MMP-13 expression and MMP-13 protein synthesis
 Hannafin et al. [11] Canine, adult, mixed age and sex, flexor digitorum tendon 8 weeks Biomechanical
Decrease in tensile modulus
Histological
Decrease in cellularity
Cell roundness
Mild increase in collagen crimps
Immunohistochemistry
N/A
 Lavagnino et al. [12] Rat, 13 months old, tail tendon 21 days Biomechanical
Decrease in ultimate tensile strength and tensile modulus
Histological
No change in collagen fiber density
Immunohistochemistry
N/A
 Wang et al. [8] Rabbit, female, 15 weeks old, Achilles tendon 6,12 days Biomechanical
N/A
Histological
Increase in cell apoptosis
Day 6: increase in cell density; Day 12: decrease in cell density
Cell roundness
Loose collagen fibers
Increase in space between collagen fibers
Wavy and disoriented fibers
Immunohistochemistry
N/A
  1. N/A stands for data not available
  2. aGlycosaminoglycans: an ECM constituent