Fig. 8

Space–time plots of propagating conditioning excitation wave and response of the tissue to a premature stimulus in the WT condition. Membrane potentials of cells are mapped onto a color spectrum. Space runs vertically from the ENDO end at the top to the EPI end at the bottom. Time runs horizontally (left to right). a–c, g, h Premature stimulus applied at ENDO part at: a 335 ms, bidirectional block. b 341.5 ms, unidirectional block. c 350 ms, bidirectional conduction. g Vulnerability of the tissue in WT-D172N and amiodarone-in-action conditions. h Vulnerability of the tissue in D172N and amiodarone-in-action conditions. d–f, i, j Premature stimulus applied at EPI part at: d 332 ms, bidirectional block. e 340 ms, unidirectional block. f 350 ms, bidirectional conduction. i Vulnerability of the tissue in WT-D172N and amiodarone-in-action conditions. j Vulnerability of the tissue in D172N and amiodarone-in-action conditions