Figure 6

Fit of the experimental glucose-induced insulin secretion in unencapsulated (free) and encapsulated islets perifused in parallel with the computational model. Experimental data are the same as in Figure 2; calculated insulin outflow in response to the same stepwise glucose is with the current model for capsule thicknesses of 0 (free islets) and l _caps = 150 μm assuming islet sizes as shown in Figure 5 and following a 2D to 3D conversion with a total islet volume scaled to 50 IEQ (see text).