Figure 2

Glucose-induced insulin secretion in unencapsulated (free) and encapsulated islets (blue diamonds and red dots, respectively). Average of experimental data for free and alginate-encapsulated mouse islets perifused in parallel using a low (3 mM; G3) → high (11 mM; G11) → low (G3) incoming glucose stimulation (plus 5 min KCl followed by G3), as shown below the x-axis. Data represent the average ± SE for three experiments performed in duplicate with ~ 50 IEQ per channel. Representative encapsulated islets used in these experiments are shown on the right.