Table 3 Parameter estimates for Model 5

M _I,b1 (mU/min/mM)

2.6 (1.6,3.2)

4.3 (2.0,5.3)

0.11

M _I,b2 (mU/min/mM)

1.0 (−0.2,2.7)

1.6 (0.1,4.7)

0.59

M _I,l (mU/min/mM)

5.0 (1.8,6.6)

2.7 (0.0,8.5)

0.48

M _I,d (mU/min/mM)

3.0 (2.5,4.8)

4.8 (0.2,8.2)

0.25

M _I,f (mU/min/mM)

0.0 (0.0,1.8)

0.0 (0.0,6.0)

0.59

M _0,b1 (mU/min/mM)

1.1 (0.9,1.7)

1.3 (0.3,1.5)

0.48

M _0,b2 (mU/min/mM)^*

1.9 (1.6,2.2)

1.7 (1.0,2.7)

0.72

M _0,l (mU/min/mM)^*

1.8 (1.1,2.8)

1.8 (1.3,2.7)

0.66

M _0,d (mU/min/mM)^*

1.6 (0.9,2.0)

1.6 (1.0,2.3)

0.59

M _0,f (mU/min/mM)^*

0.7 (0.4,1.1)

0.8 (0.6,1.5)

0.48

I _peak,b (mU/min)

7.8 (0.0,14.0)

17.8 (0.0,21.1)

0.27

I _peak,l (mU/min)

0.0 (0.0,13.9)

13.2 (0.0,30.5)

0.02

MCR _I (l/kg/min)^**

0.013 (0.005)

as Closed-loop

NA