Table 4 Summary of drug-induced differences in model parameters compared to control.
| Â | Before Ischemia | After Ischemia | ||||||
|---|---|---|---|---|---|---|---|---|
Parameter | Dbt | Dop | Dig | Lev | Dbt | Dop | Dig | Lev |
α 1 (1/μM•s) | ↓ | ↓ | NC | NC | NC | ↑ | ↑ | ↑ |
α a (1/μM•s) | ↑ | ↑ | NC | NC | ↑ | ↑ | ↑ | NC |
β 1 (1/μM•s) | NC | ↑ | NC | NC | ↓ | NC | NC | ↓ |
β a (1/μM•s) | NC | ↓ | NC | ↓ | ↑ | ↑ | ↑ | ↑ |
K 2 (1/μM•s) | ↑ | NC | NC | NC | NC | NC | NC | ↑ |
K 3 (1/s) | NC | ↓ | NC | NC | NC | ↑ | ↑ | ↓ |
K 4 (1/s) | ↑ | ↑ | NC | ↑ | ↑ | NC | NC | NC |
K d (1/s) | ↑ | ↑ | NC | NC | ↑ | ↑ | ↑ | ↑ |
K d ' (1/s) | ↑ | ↑ | NC | NC | NC | NC | NC | NC |