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Table 4 Summary of drug-induced differences in model parameters compared to control.

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

  Before Ischemia After Ischemia
Parameter Dbt Dop Dig Lev Dbt Dop Dig Lev
α 1 (1/μM•s) NC NC NC
α a (1/μM•s) NC NC NC
β 1 (1/μM•s) NC NC NC NC NC
β a (1/μM•s) NC NC
K 2 (1/μM•s) NC NC NC NC NC NC
K 3 (1/s) NC NC NC NC
K 4 (1/s) NC NC NC NC
K d (1/s) NC NC
K d ' (1/s) NC NC NC NC NC NC
  1. Arrows indicate directional differences in drug effects on model parameters from pre- and post-ischemic controls. NC = no change. Data obtained 25 min before and 35 min after global ischemia in the presence of drugs.