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Table 3 Effects of positive inotropic drugs on model parameters when administered before and after global ischemia.

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

Before Ischemia After Ischemia
Con Dbt Dop Dig Lev Con Dbt Dop Dig Lev
Second order rate constants Second order rate constants
α 1 (1/μM•s) α 1 (1/μM•s)
4.5 ± 0.3 2.2 ± 0.2* 2.3 ± 0.3* 4.2 ± 0.3 4.4 ± 0.5 0.5 ± 0.1† 0.5 ± 0.2† 1.2 ± 0.2# 1.1 ± 0.2# 1.6 ± 0.4#
α a (1/μM•s) α a (1/μM•s)
5.0 ± 0.2 8.0 ± 0.8* 14 ± 3* 5.8 ± 0.5 5.2 ± 0.3 1.7 ± 0.4† 4 ± 1# 3.8 ± 0.6# 4.2 ± 0.7# 2.4 ± 0.4†
β 1 (1/μM•s) β 1 (1/μM•s)
0.12 ± 0.07 0.18 ± 0.15 2.2 ± 0.8* 0.2 ± 0.1 1.8 ± 0.9 10 ± 3† 4 ± 1# 9.0 ± 0.5† 10 ± 2† 5.7 ± 2.0#
β a (1/μM•s) β a (1/μM•s)
118 ± 12 83 ± 9 29 ± 13* 110 ± 10 56 ± 9* 5.2 ± 0.7† 10 ± 2# 11 ± 3# 13 ± 4# 15 ± 8#
K 2 (1/μM•s) K 2 (1/μM•s)
418 ± 14 775 ± 82* 355 ± 68 485 ± 59 351 ± 62 151 ± 63† 275 ± 41† 262 ± 76 249 ± 28† 250 ± 9#
First order rate constants First order rate constants
K 3 (1/s) K 3 (1/s)
429 ± 24 348 ± 46 174 ± 42* 434 ± 31 508 ± 63 271 ± 39† 270 ± 43 517 ± 26# 480 ± 24# 178 ± 19#
K 4 (1/s) K 4 (1/s)
18 ± 4 80 ± 17* 52 ± 9* 28 ± 9 37 ± 7* 60 ± 8† 90 ± 10# 65 ± 11 69 ± 6† 67 ± 13†
K d (1/s) K d (1/s)
484 ± 21 872 ± 29* 656 ± 54* 500 ± 20 593 ± 71 87 ± 13† 331 ± 27# 183 ± 30# 227 ± 77# 325 ± 47#
K d '(1/s) K d '(1/s)
765 ± 81 977 ± 32* 1218 ± 11* 728 ± 88 751 ± 64 377 ± 25† 375 ± 15† 378 ± 1† 450 ± 72† 398 ± 27†
  1. Values are expressed as mean ± SE. Con = Control, Dbt = Dobutamine, Dop = Dopamine, Dig = Digoxin, Lev = Levosimendan. Statistical significance was measured at *p < 0.05 vs. Control before ischemia, #p < 0.05 vs. Control after ischemia, †p < 0.05 after vs. before ischemia in the presence or absence of drugs.