Table 3 Effects of positive inotropic drugs on model parameters when administered before and after global ischemia.

Con

Dbt

Dop

Dig

Lev

Con

Dbt

Dop

Dig

Lev

Second order rate constants

Second order rate constants

α ₁ (1/μM•s)

α ₁ (1/μM•s)

4.5 ± 0.3

2.2 ± 0.2*

2.3 ± 0.3*

4.2 ± 0.3

4.4 ± 0.5

0.5 ± 0.1†

0.5 ± 0.2†

1.2 ± 0.2^#

1.1 ± 0.2^#†

1.6 ± 0.4^#†

α _a (1/μM•s)

α _a (1/μM•s)

5.0 ± 0.2

8.0 ± 0.8*

14 ± 3*

5.8 ± 0.5

5.2 ± 0.3

1.7 ± 0.4†

4 ± 1^#†

3.8 ± 0.6^#†

4.2 ± 0.7^#

2.4 ± 0.4†

β ₁ (1/μM•s)

β ₁ (1/μM•s)

0.12 ± 0.07

0.18 ± 0.15

2.2 ± 0.8*

0.2 ± 0.1

1.8 ± 0.9

10 ± 3†

4 ± 1^#†

9.0 ± 0.5†

10 ± 2†

5.7 ± 2.0^#†

β _a (1/μM•s)

β _a (1/μM•s)

118 ± 12

83 ± 9

29 ± 13*

110 ± 10

56 ± 9*

5.2 ± 0.7†

10 ± 2^#†

11 ± 3^#†

13 ± 4^#†

15 ± 8^#†

K ₂ (1/μM•s)

K ₂ (1/μM•s)

418 ± 14

775 ± 82*

355 ± 68

485 ± 59

351 ± 62

151 ± 63†

275 ± 41†

262 ± 76

249 ± 28†

250 ± 9^#†

First order rate constants

First order rate constants

K ₃ (1/s)

K ₃ (1/s)

429 ± 24

348 ± 46

174 ± 42*

434 ± 31

508 ± 63

271 ± 39†

270 ± 43

517 ± 26^#†

480 ± 24^#

178 ± 19^#†

K ₄ (1/s)

K ₄ (1/s)

18 ± 4

80 ± 17*

52 ± 9*

28 ± 9

37 ± 7*

60 ± 8†

90 ± 10^#

65 ± 11

69 ± 6†

67 ± 13†

K _d (1/s)

K _d (1/s)

484 ± 21

872 ± 29*

656 ± 54*

500 ± 20

593 ± 71

87 ± 13†

331 ± 27^#†

183 ± 30^#†

227 ± 77^#†

325 ± 47^#†

K _d '(1/s)

K _d '(1/s)

765 ± 81

977 ± 32*

1218 ± 11*

728 ± 88

751 ± 64

377 ± 25†

375 ± 15†

378 ± 1†

450 ± 72†

398 ± 27†