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Table 1 Model parameters and brief description.

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

Parameter Name Description
K1 (1/μM•s) Cooperative binding rate constant of Ca2+ to TnCA
Ka (1/μM•s) Cooperative rate constant of formation of A•M
K2 (1/μM•s) Association rate constant of Ca2+ to A•M
K3 (1/s) Dissociation rate constant of Ca2+ from TnCA
K4 (1/s) Dissociation rate constant of Ca2+ from A•M
Kd (1/s) Dissociation rate constant of A•M in the presence of attached Ca2+
Kd' (1/s) Dissociation rate constant of A•M in the absence of attached Ca2+
  1. K = rate constants characterizing the 4-state model are pictured in Figure 1 and described in detail in the Appendix. A = Actin, M = Myosin, TnCA = Troponin C on the A filament, A•M = actinomyosin cross-bridges.