Skip to main content

Table 1 Model parameters and brief description.

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

Parameter Name

Description

K1 (1/μM•s)

Cooperative binding rate constant of Ca2+ to TnCA

Ka (1/μM•s)

Cooperative rate constant of formation of A•M

K2 (1/μM•s)

Association rate constant of Ca2+ to A•M

K3 (1/s)

Dissociation rate constant of Ca2+ from TnCA

K4 (1/s)

Dissociation rate constant of Ca2+ from A•M

Kd (1/s)

Dissociation rate constant of A•M in the presence of attached Ca2+

Kd' (1/s)

Dissociation rate constant of A•M in the absence of attached Ca2+

  1. K = rate constants characterizing the 4-state model are pictured in Figure 1 and described in detail in the Appendix. A = Actin, M = Myosin, TnCA = Troponin C on the A filament, A•M = actinomyosin cross-bridges.