Figure 4
From: Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
Electrical coupling between human embryonic stem cell-derived cardiomyocyte and fibroblasts. (A, C) Effects on action potentials (APs), Early and Late stage respectively, of a variable number (Nf,) of fibroblasts. (B, D) Consequent changes of AP features, Early and Late stage respectively: both stages show an increment of the rate of spontaneous beating and an APA reduction. APD is slightly prolonged at the Early stage (especially APD70 and APD90) while at the Late stage the fibroblast effects are minor, showing only a slight reduction of APD30.