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  1. Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role of hy...

    Authors: Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Meng Yan and Jun Xiao
    Citation: BioMedical Engineering OnLine 2021 20:88
  2. Ovarian cancer is one of the most common gynecological malignancies with the high morbidity and mortality. This study was aimed to explore the role of non-structure maintenance of chromosomes condensin I compl...

    Authors: Yingying Qi, Kexin Mo and Ting Zhang
    Citation: BioMedical Engineering OnLine 2021 20:83
  3. The effect of the COVID-19 pandemic on higher education has been felt worldwide. There are many lessons to be learned about teaching and learning in the digital age. While we evaluate the full impact and prepa...

    Authors: Seema Biswas, Oren Dahan, Evgeny Solomonov, Igor Waksman and Orit Braun Benyamin
    Citation: BioMedical Engineering OnLine 2021 20:82
  4. Knee osteoarthritis (KOA) is a common cause of disability among the elderly. We aimed to explore the effects of aldehyde dehydrogenase (ALDH) 2 on the progression of KOA and identifying the potential mechanisms.

    Authors: Lingxiao Pan, Wei Ding, Jie Li, Kaifeng Gan, Yandong Shen, Junxiang Xu and Minzhe Zheng
    Citation: BioMedical Engineering OnLine 2021 20:80
  5. Anterior resection syndrome (ARS) is characterized by the diverse and interchangeable evacuatory symptoms that may occur following distal colorectal resection. We aimed to investigate the effect and potential ...

    Authors: Wei Zhang, Meng Wu, Peng Chen, Jiamin Zhang, Jiaze Ma, Yile Cheng, Xiaoliu Li, Junjie Hu, Wanli Li, Yuxin Du, Kang Ding and Zhimin Fan
    Citation: BioMedical Engineering OnLine 2021 20:79
  6. Fractional flow reserve (FFR) is a widely used gold standard to evaluate ischemia-causing lesions. A new method of non-invasive approach, termed as AccuFFRct, for calculating FFR based on coronary computed tomogr...

    Authors: Wenbing Jiang, Yibin Pan, Yumeng Hu, Xiaochang Leng, Jun Jiang, Li Feng, Yongqing Xia, Yong Sun, Jian’an Wang, Jianping Xiang and Changling Li
    Citation: BioMedical Engineering OnLine 2021 20:77
  7. Phytochemical agents such as thymoquinone (TQ) have osteogenic property. This study aimed to investigate the synergic impact of TQ and hydroxyapatite on mesenchymal stem cell differentiation. Alginate was also...

    Authors: Ebrahim Rahmani-Moghadam, Tahereh Talaei-Khozani, Vahideh Zarrin and Zahra Vojdani
    Citation: BioMedical Engineering OnLine 2021 20:76
  8. Schizophrenia is a chronic and severe mental disease, which largely influences the daily life and work of patients. Clinically, schizophrenia with negative symptoms is usually misdiagnosed. The diagnosis is al...

    Authors: Jia Fu, Sen Yang, Fei He, Ling He, Yuanyuan Li, Jing Zhang and Xi Xiong
    Citation: BioMedical Engineering OnLine 2021 20:75
  9. Cerebral edema is a common condition secondary to any type of neurological injury. The early diagnosis and monitoring of cerebral edema is of great importance to improve the prognosis. In this article, a flexi...

    Authors: Jingbo Chen, Gen Li, Huayou Liang, Shuanglin Zhao, Jian Sun and Mingxin Qin
    Citation: BioMedical Engineering OnLine 2021 20:74
  10. Using Ambient Assisted Living sensors to detect acute stress could help people mitigate the harmful effects of everyday stressful situations. This would help both the healthy and those affected more by sudden ...

    Authors: Benedek Szakonyi, István Vassányi, Edit Schumacher and István Kósa
    Citation: BioMedical Engineering OnLine 2021 20:73
  11. The visualization and analysis of brain data such as white matter diffusion tractography and magnetic resonance imaging (MRI) volumes is commonly used by neuro-specialist and researchers to help the understand...

    Authors: Ignacio Osorio, Miguel Guevara, Danilo Bonometti, Diego Carrasco, Maxime Descoteaux, Cyril Poupon, Jean-François Mangin, Cecilia Hernández and Pamela Guevara
    Citation: BioMedical Engineering OnLine 2021 20:72
  12. The classification of benign and malignant microcalcification clusters (MCs) is an important task for computer-aided diagnosis (CAD) of digital breast tomosynthesis (DBT) images. Influenced by imaging method, ...

    Authors: Bingbing Xiao, Haotian Sun, You Meng, Yunsong Peng, Xiaodong Yang, Shuangqing Chen, Zhuangzhi Yan and Jian Zheng
    Citation: BioMedical Engineering OnLine 2021 20:71
  13. The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus impr...

    Authors: Jungang Li, Chaoqian Zhao, Chun Liu, Zhenyu Wang, Zeming Ling, Bin Lin, Bizhi Tan, Linquan Zhou, Yan Chen, Delong Liu, Xuenong Zou and Wenge Liu
    Citation: BioMedical Engineering OnLine 2021 20:70
  14. Hypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement fibrosis, impaired contractility, and elevated filling pressures. These var...

    Authors: Ekaterina Kovacheva, Tobias Gerach, Steffen Schuler, Marco Ochs, Olaf Dössel and Axel Loewe
    Citation: BioMedical Engineering OnLine 2021 20:69
  15. Continuous long-term electrocardiography monitoring has been increasingly recognized for early diagnosis and management of different types of cardiovascular diseases. To find an alternative to Ag/AgCl gel elec...

    Authors: Milad Alizadeh-Meghrazi, Binbin Ying, Alessandra Schlums, Emily Lam, Ladan Eskandarian, Farhana Abbas, Gurjant Sidhu, Amin Mahnam, Bastien Moineau and Milos R. Popovic
    Citation: BioMedical Engineering OnLine 2021 20:68
  16. Hepatocellular carcinoma (HCC) is currently the sixth most common malignancy and the second major cause of tumor-related deaths in the world. This study aimed to investigate the role of cleavage and polyadenyl...

    Authors: Yang Liu, Hongbo Zou, Qichao Xie, Lan Zou, Rui Kong and Bijing Mao
    Citation: BioMedical Engineering OnLine 2021 20:67
  17. To provide surgical support for corrective osteotomy, we developed an image fusion system for three-dimensional (3D) preoperative planning and fluoroscopy. To assess the utility of this image fusion system, we...

    Authors: Yuichi Yoshii, Takeshi Ogawa, Yuki Hara, Yasukazu Totoki and Tomoo Ishii
    Citation: BioMedical Engineering OnLine 2021 20:66
  18. This study used machine learning classification of texture features from MRI of breast tumor and peri-tumor at multiple treatment time points in conjunction with molecular subtypes to predict eventual patholog...

    Authors: Lal Hussain, Pauline Huang, Tony Nguyen, Kashif J. Lone, Amjad Ali, Muhammad Salman Khan, Haifang Li, Doug Young Suh and Tim Q. Duong
    Citation: BioMedical Engineering OnLine 2021 20:63
  19. Pathological gaits of children may lead to terrible diseases, such as osteoarthritis or scoliosis. By monitoring the gait pattern of a child, proper therapeutic measures can be recommended to avoid the terribl...

    Authors: Linghui Xu, Jiansong Chen, Fei Wang, Yuting Chen, Wei Yang and Canjun Yang
    Citation: BioMedical Engineering OnLine 2021 20:62
  20. The use of machine learning (ML) techniques in healthcare encompasses an emerging concept that envisages vast contributions to the tackling of rare diseases. In this scenario, amyotrophic lateral sclerosis (AL...

    Authors: Felipe Fernandes, Ingridy Barbalho, Daniele Barros, Ricardo Valentim, César Teixeira, Jorge Henriques, Paulo Gil and Mário Dourado Júnior
    Citation: BioMedical Engineering OnLine 2021 20:61
  21. Peripheral nerve injury can cause significant impairment, and the current methods for facilitating repair, particularly over distances greater than approximately 1 mm, are not entirely effective. Allografts, a...

    Authors: Julia Towne, Nicklaus Carter and David J. Neivandt
    Citation: BioMedical Engineering OnLine 2021 20:60
  22. Nebulizers are medical devices that deliver aerosolized medication directly to lungs to treat a variety of respiratory diseases. However, breathing patterns, respiration rates, airway diameters, and amounts of...

    Authors: Hyun Mok Park, Kyung Hwa Chang, Sang-Hyub Moon, Bong Joo Park, Sun Kook Yoo and Ki Chang Nam
    Citation: BioMedical Engineering OnLine 2021 20:59
  23. To explore the analgesic efficacy of extracorporeal shock wave (ESW) combined with percutaneous vertebroplasty (PVP) after reduction in overextension position in the treatment of osteoporotic thoracolumbar com...

    Authors: Xiaowei Liu, Hui Wang, Yang Zhang, Mingling Wang, Yujin Qiu, Xiaodong Sun and Sheng Wang
    Citation: BioMedical Engineering OnLine 2021 20:58
  24. Breast cancer is one of the most serious diseases threatening women’s health. Early screening based on ultrasound can help to detect and treat tumours in the early stage. However, due to the lack of radiologis...

    Authors: Xiaoyan Shen, He Ma, Ruibo Liu, Hong Li, Jiachuan He and Xinran Wu
    Citation: BioMedical Engineering OnLine 2021 20:57
  25. The spinal nerve ligation (SNL) rat is well known as the most common rodent model of neuropathic pain without motor deficit. Researchers have performed analyses using only the von Frey and thermal withdrawal t...

    Authors: Takayuki Seto, Hidenori Suzuki, Tomoya Okazaki, Yasuaki Imajo, Norihiro Nishida, Masahiro Funaba, Tsukasa Kanchiku, Toshihiko Taguchi and Takashi Sakai
    Citation: BioMedical Engineering OnLine 2021 20:55
  26. To develop a novel subjective–objective-combined (SOC) grading standard for auto-segmentation for each organ at risk (OAR) in the thorax.

    Authors: Yanchen Ying, Hao Wang, Hua Chen, Jianfan Cheng, Hengle Gu, Yan Shao, Yanhua Duan, Aihui Feng, Wen Feng, Xiaolong Fu, Hong Quan and Zhiyong Xu
    Citation: BioMedical Engineering OnLine 2021 20:54
  27. Active human body models (AHBM) consider musculoskeletal movement and joint stiffness via active muscle truss elements in the finite element (FE) codes in dynamic application. In the latest models, such as THU...

    Authors: Niclas Trube, Werner Riedel and Matthias Boljen
    Citation: BioMedical Engineering OnLine 2021 20:53
  28. Establishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an indep...

    Authors: Jingshu Ni, Haiou Hong, Yang Zhang, Shiqi Tang, Yongsheng Han, Zhaohui Fang, Yuanzhi Zhang, Nan Zhou, Quanfu Wang, Yong Liu, Zhongsheng Li, YiKun Wang and Meili Dong
    Citation: BioMedical Engineering OnLine 2021 20:52
  29. Early detection of laryngeal masses without periodic visits to hospitals is essential for improving the possibility of full recovery and the long-term survival ratio after prompt treatment, as well as reducing...

    Authors: Gun Ho Kim, Eui-Suk Sung and Kyoung Won Nam
    Citation: BioMedical Engineering OnLine 2021 20:51
  30. Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances. The correct diagn...

    Authors: Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade and Adriano Alves Pereira
    Citation: BioMedical Engineering OnLine 2021 20:50
  31. Effective maintenance management of medical equipment is one of the major issues for quality of care, for providing cost-effective health services and for saving scarce resources. This study aimed to develop a...

    Authors: Morteza Arab-Zozani, Ali Imani, Leila Doshmangir, Koustuv Dalal and Rona Bahreini
    Citation: BioMedical Engineering OnLine 2021 20:49
  32. Research on the degradation of silk fibroin (SF) scaffolds in vivo lacks uniform and effective standards and experimental evaluation methods. This study aims to evaluate the application of ultrasound in assess...

    Authors: Lihui Cai, Nan Gao, TingYu Sun, Ke Bi, Xin Chen and Xia Zhao
    Citation: BioMedical Engineering OnLine 2021 20:48
  33. Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in th...

    Authors: Michael Neidlin, Sam Liao, Zhiyong Li, Benjamin Simpson, David M. Kaye, Ulrich Steinseifer and Shaun Gregory
    Citation: BioMedical Engineering OnLine 2021 20:47
  34. Coronary stents are routinely placed in the treatment and prophylaxis of coronary artery disease (CAD). Current coronary stent designs are prone to developing blockages: in-stent thrombosis (IST) and in-stent ...

    Authors: Joseph Robert Stevens, Ava Zamani, James Ian Atkins Osborne, Reza Zamani and Mohammad Akrami
    Citation: BioMedical Engineering OnLine 2021 20:46
  35. Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by ...

    Authors: Zhaoke Pi, Mengke Wang, Haoming Lin, Yanrong Guo, Siping Chen, Xianfen Diao, Hui Xia, Guoqiang Liu, Jie Zeng, Xinyu Zhang and Xin Chen
    Citation: BioMedical Engineering OnLine 2021 20:45
  36. Cerebrovascular disease, in particular stroke, is a major public health challenge. An important biomarker is cerebral hemodynamics. To measure and quantify cerebral hemodynamics, however, only invasive, potent...

    Authors: Dietmar Frey, Michelle Livne, Heiko Leppin, Ela M. Akay, Orhun U. Aydin, Jonas Behland, Jan Sobesky, Peter Vajkoczy and Vince I. Madai
    Citation: BioMedical Engineering OnLine 2021 20:44
  37. Recognition of facial expressions (FEs) plays a crucial role in social interactions. Most studies on FE recognition use static (image) stimuli, even though real-life FEs are dynamic. FE processing is complex a...

    Authors: Tuba Aktürk, Tom A. de Graaf, Yasemin Abra, Sevilay Şahoğlu-Göktaş, Dilek Özkan, Aysun Kula and Bahar Güntekin
    Citation: BioMedical Engineering OnLine 2021 20:41
  38. Small-incision lenticule extraction (SMILE) is a surgical procedure for the refractive correction of myopia and astigmatism, which has been reported as safe and effective. However, over- and under-correction s...

    Authors: Seungbin Park, Hannah Kim, Laehyun Kim, Jin-kuk Kim, In Sik Lee, Ik Hee Ryu and Youngjun Kim
    Citation: BioMedical Engineering OnLine 2021 20:38