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Table 4 Update rules for FIO\(_2\) based on current SpO\(_2\) value

From: SOLVe: a closed-loop system focused on protective mechanical ventilation

SpO\(_2\)

Description

Update rule

Update time

 > high target + 4

Greatly above target

Decrease FIO\(_2\) by 0.1

100 s

 > high target + 2

Above target

Decrease FIO\(_2\) by 0.05

100 s

 > high target

Slightly above target

Decrease FIO\(_2\) by 0.02

100 s

 > target middle

Upper target region

If stable: decr. 0.02, else: no change

20 min

 > low target

Lower target region

No change

 < low target

Slightly below target

Increase FIO\(_2\) by 0.02

40 s

 < low target -2

Below target

Increase FIO\(_2\) by 0.05

20 s

 \(\le\) 85

SpO\(_2\) low state

Set FIO\(_2\) to 1.0

Immediately