Fig. 7

circRNAs were directly differentially expressed in VLS tissues and normal tissues. A Volcanic map of VLS differential gene expression level. The horizontal axis represented the normalized difference (VLS group/normal group), and the vertical axis represented the normalized P value. In the figure, red represented the up-regulated significantly differentially expressed genes, blue represented the down-regulated significantly differentially expressed genes, and the gray dots represented the non-significantly differentially expressed genes. B Statistical chart of down-regulated frequency of VLS genes with significantly different expression. The red column represented up-regulated gene frequency, and the blue column represented down-regulated gene frequency. C Cluster analysis diagram of VLS differential gene expression level. The horizontal axis was the sample (VLS group/normal group), and the vertical axis was the gene. Different colors represented different gene expression levels, and the color ranged from blue to white to red to indicate the expression amount (log10(FPKM + 1)) from low to high. High expression genes were in red and low expression genes were in dark blue