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Fig. 3 | BioMedical Engineering OnLine

Fig. 3

From: Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

Fig. 3

Upregulation of CUL3 expression combined with activation of SHH signaling protected against Ang II-induced VSMCs damage. A Detection of CUL3 mRNA expression with RT-qPCR. ***P < 0.001 vs. NC. B Cell viability was tested with a CCK-8 assay. C Measurement of cell migration using Transwell migration assay. Magnification, × 100. D Cell apoptosis was assessed by TUNEL staining. Magnification, × 200. E ROS level was determined with commercial available kit. ***P < 0.001 vs. control; #P < 0.05, ###P < 0.001 vs. Ang II; P < 0.05, P < 0.001 vs. Ang II + NC; $$$P < 0.001 vs. Ang II + NC + SAG

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