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Fig. 1 | BioMedical Engineering OnLine

Fig. 1

From: Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

Fig. 1

Ang II stimulation promoted proliferation, migration, oxidative stress and apoptosis of VSMCs as well as activated SHH signaling. A Cell viability was measured by a CCK-8 assay. B ROS content was evaluated using the commercial kit. C, D Detection of cell migration using Transwell migration assay. Magnification, × 100. E TUNEL staining was adopted for the determination of cell apoptosis. Magnification, × 200. F Analysis of protein expression related to SHH signaling by western blot analysis. G The correction between SHH expression and cell proliferation. H The correction between SHH expression and cell apoptosis. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control

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BioMedical Engineering OnLine

ISSN: 1475-925X

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