Table 4 Recommended parameter ranges based on literature

Respiratory rate, RR (breaths/min)

6–35

ARDSNet trial [10]

Tidal volume, V_T (mL/kg)

4–8

ARDSNet trial [10], State-of-the-Art review for Mechanical Ventilation in ARDS [72], Official Society of Critical Care Medicine Practice Guideline [7]

Positive end-expiratory pressure, PEEP (cmH₂O)

Specified by clinician

ALVEOLI trial [4], LOVS trial [11], EXPRESS trial [12], Hogson staircase recruitment trial [73], Individualised PEEP trial [28], EPVent trial [74]

Peak pressure, P_MAX (cmH₂O)

< 40

The basics of respiratory mechanics [75]

Plateau pressure, P_PLAT (cmH₂O)

< 30

State-of-the-Art review for Mechanical Ventilation in ARDS [72], Official Society of Critical Care Medicine Practice Guideline [7]

I:E ratio

1:1–1:3

ARDSNet trial [10], ALVEOLI trial [4], LOVS trial [11], EXPRESS trial [12]