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Fig. 1 | BioMedical Engineering OnLine

Fig. 1

From: Evaluating effect of metallic ions on aggregation behavior of β-amyloid peptides by atomic force microscope and surface-enhanced Raman Scattering

Fig. 1

Experimental setup of AFM. a A schematic diagram of mercaptan self-assembly method, which shows covalent attachment of Aβ42 on the carboxyl terminal of thiol-modified gold substrate. b A typical force–distance curve with recorded rupture force (Fa − Fb). Aβ42 is immobilized on the Au-modified mica surface via MHA linker. The counterpart Aβ42 is immobilized on the MHA functionalized Au-coated tip

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