Fig. 8
From: Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes
(+)-JQ1 promoted the apoptosis of HaCAT cells induced by TNF-α or IL-17A. A Apoptosis of HaCAT cells induced by TNF-α was determined by TUNEL assay. B Expression of apoptosis-related proteins in HaCAT cells induced by TNF-α was detected by Western blot analysis. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. Vehicle group. #P < 0.05 and ###P < 0.001 vs. TNF-α 50 ng/ml group. C Apoptosis of HaCAT cells induced by IL-17A was determined by TUNEL assay. D Expression of apoptosis-related proteins in HaCAT cells induced by IL-17A was detected by Western blot analysis. **P < 0.01 and ***P < 0.001 vs. Vehicle group. ##P < 0.01 and ###P < 0.001 vs. IL-17A 50 ng/ml group