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Fig. 7 | BioMedical Engineering OnLine

Fig. 7

From: Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes

Fig. 7

(+)-JQ1 suppressed the inflammation and proliferation, and promoted the apoptosis of HaCAT cells induced by TNF-α or IL-17A. A Expression levels of IFN-γ, IL-8 and IL-6 in culture supernatant of HaCAT cells induced by TNF-α were analyzed by ELISA assay. *P < 0.05 and ***P < 0.001 vs. Vehicle group. ###P < 0.001 vs. TNF-α 50 ng/ml group. B Expression levels of IFN-γ, IL-8 and IL-6 in culture supernatant of HaCAT cells induced by IL-17A were analyzed by ELISA assay. ***P < 0.001 vs. Vehicle group. ###P < 0.001 vs. IL-17A 50 ng/ml group. C Expression of KI67 and PCNA in HaCAT cells induced by TNF-α was detected by Western blot analysis. *P < 0.05 and ***P < 0.001 vs. Vehicle group. ##P < 0.01 vs. TNF-α 50 ng/ml group. D Expression of KI67 and PCNA in HaCAT cells induced by IL-17A was detected by Western blot analysis. **P < 0.01 and ***P < 0.001 vs. Vehicle group. #P < 0.05 vs. IL-17A 50 ng/ml group

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