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Fig. 3 | BioMedical Engineering OnLine

Fig. 3

From: Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes

Fig. 3

(+)-JQ1 decreased the release of inflammatory factors in serum and increased the apoptosis of keratinocytes of imiquimod-induced mice. A Expression levels of IFN-γ, IL-8 and IL-6 in serum were analyzed by ELISA assay. B Expression of p65 and IkBα in skin tissues was detected by Western blot analysis. C Apoptosis of keratinocytes in skin tissues was determined by TUNEL assay. D Expression of apoptosis-related proteins in skin tissues was detected by Western blot analysis. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. Control group. #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. Model group. $P < 0.05, $$P < 0.01 and $$$P < 0.001 vs. (+)-JQ1 group

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