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Table 1 Summary of the chronic implantations of the OPTO-EPIRET device in rabbits

From: New epiretinal implant with integrated sensor chips for optical capturing shows a good biocompatibility profile in vitro and in vivo

Animal no.

Duration of surgery (h:min)

Adverse events during surgery

Follow-up adverse events

OCT-imaging

Open-sky imaging

1

2:20

Dislocation of sensor chip, mild vitreal hemorrhage, difficult fixation using retinal tack, corneal edema

Corneal edema with neovascularization (see Fig. 6)

Retina: good quality, parts of implant with distance to retina; cornea: good quality, corneal edema (see Fig. 6)

Retinal detachment (superior hemisphere), mild gliosis on array

2

1:45

Retinal tear (inferior hemisphere), difficult fixation using retinal tack, corneal edema

Slight corneal edema

Retina: acceptable quality, gliosis, pricking with one wing into retina; cornea: good quality, corneal scar

Slight retinal detachment

3

1:20

Retinal tear (temporal hemisphere), difficult fixation using retinal tack, corneal edema

Fibrinous reaction (control at week 5 no fibrin), subluxation of the retinal tack, slight corneal edema

Retina: good quality, gliosis, central good contact (see Fig. 7), at least one wing deviated; cornea: good quality, corneal edema

Insufficient fixation of retinal tack, two wings deviated, retinal detachment

4

1:35

Retinal tear (central retina), difficult fixation using retinal tack, corneal edema

Ectropion, vitreal hemorrhage, low IOP, severe vascularization of corneal edema, suspected dislocation of the array, premature finalization after 3 weeks (d23)

Retina: not good quality; cornea: not performed

Vitreal hemorrhage, gliosis

5

1:10

Corneal edema

Very slight corneal edema

Retina: good quality, partly no good contact between array and retina, gliosis, pricking with one wing into retina (see Fig. 7); cornea: good quality, central normal corneal thickness, just slight edema peripheral (see Fig. 6)

Gliosis on array

6

1:45

Dislocation of one sensor chip, corneal edema

Weight loss, slight corneal edema, week 2 breathing arrest under anesthesia (suspicion of heart problems)

Retina: good quality, good contact (see Fig. 7), not good contact of one wing, gliosis; cornea: good quality, no corneal edema

Gliosis on array, dislocation of one sensor chip, good contact, retinal detachment

  1. d day, IOP intraocular pressure