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Table 1 Summary of the chronic implantations of the OPTO-EPIRET device in rabbits

From: New epiretinal implant with integrated sensor chips for optical capturing shows a good biocompatibility profile in vitro and in vivo

Animal no. Duration of surgery (h:min) Adverse events during surgery Follow-up adverse events OCT-imaging Open-sky imaging
1 2:20 Dislocation of sensor chip, mild vitreal hemorrhage, difficult fixation using retinal tack, corneal edema Corneal edema with neovascularization (see Fig. 6) Retina: good quality, parts of implant with distance to retina; cornea: good quality, corneal edema (see Fig. 6) Retinal detachment (superior hemisphere), mild gliosis on array
2 1:45 Retinal tear (inferior hemisphere), difficult fixation using retinal tack, corneal edema Slight corneal edema Retina: acceptable quality, gliosis, pricking with one wing into retina; cornea: good quality, corneal scar Slight retinal detachment
3 1:20 Retinal tear (temporal hemisphere), difficult fixation using retinal tack, corneal edema Fibrinous reaction (control at week 5 no fibrin), subluxation of the retinal tack, slight corneal edema Retina: good quality, gliosis, central good contact (see Fig. 7), at least one wing deviated; cornea: good quality, corneal edema Insufficient fixation of retinal tack, two wings deviated, retinal detachment
4 1:35 Retinal tear (central retina), difficult fixation using retinal tack, corneal edema Ectropion, vitreal hemorrhage, low IOP, severe vascularization of corneal edema, suspected dislocation of the array, premature finalization after 3 weeks (d23) Retina: not good quality; cornea: not performed Vitreal hemorrhage, gliosis
5 1:10 Corneal edema Very slight corneal edema Retina: good quality, partly no good contact between array and retina, gliosis, pricking with one wing into retina (see Fig. 7); cornea: good quality, central normal corneal thickness, just slight edema peripheral (see Fig. 6) Gliosis on array
6 1:45 Dislocation of one sensor chip, corneal edema Weight loss, slight corneal edema, week 2 breathing arrest under anesthesia (suspicion of heart problems) Retina: good quality, good contact (see Fig. 7), not good contact of one wing, gliosis; cornea: good quality, no corneal edema Gliosis on array, dislocation of one sensor chip, good contact, retinal detachment
  1. d day, IOP intraocular pressure