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Fig. 4 | BioMedical Engineering OnLine

Fig. 4

From: Celastrol inhibits the proliferation and angiogenesis of high glucose-induced human retinal endothelial cells

Fig. 4

Celastrol inhibits the angiogenesis of HG-induced hRECs. A The branching points in hRECs induced with HG and treated with different concentrations of celastrol were observed by tube formation assay. B Inverted micrographs of branching points in hRECs induced with HG and treated with different concentrations of celastrol. C Representative western blots and D quantitative analysis for expression of HIF-1α and VEGF in hRECs induced with HG and treated with different concentrations of celastrol was detected by Western blot analysis. E The mRNA expression of HIF-1α and VEGF in hRECs induced with HG and treated with different concentrations of celastrol was detected by RT-qPCR analysis. F The expression of ICAM-1 in hRECs induced with HG and treated with different concentrations of celastrol was detected by immunofluorescence assay. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. NG group. #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. HG group. P < 0.05 vs. HG + 0.5 μM cela group. $P < 0.05 and $$$P < 0.001 vs. HG + 1.0 μM cela group. Cela: celastrol

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