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Table 2 Effect of model changes reflecting different pathological mechanisms (columns) on phenotypic mechanical markers (rows). WT = wall thickness, FA = fractional anisotropy, and Comb. = combination

From: Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study

Metrics Time period WT \(\uparrow\) Passive force \(\uparrow\) Active force \(\downarrow\) FA \(\uparrow\) Comb.
Wall thickening Systolic (ES) \(\uparrow\) (\(\approx\)) \(\downarrow\) (\(\downarrow\)) \(\downarrow\) (\(\downarrow\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\downarrow\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\))
Strain (L) Systolic (ES) \(\uparrow\) (\(\uparrow\)) \(\uparrow\) (\(\uparrow\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\downarrow\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\))
Strain (C) Systolic (ES) \(\uparrow\) (\(\approx\)) \(\uparrow\) (\(\uparrow\)) \(\uparrow\) (\(\uparrow\)) \(\uparrow\) (\(\approx\)) \(\uparrow\) (\(\uparrow\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\))
Strain (R) Systolic (ES) \(\uparrow\) (\(\approx\)) \(\downarrow\) (\(\downarrow\)) \(\downarrow\) (\(\downarrow\)) \(\downarrow\) (\(\approx\)) \(\downarrow\) (\(\downarrow\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\))
Strain rate (L) Systolic (ES) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\approx\))
Strain rate (C) Systolic (ES) \(\downarrow\) (\(\approx\)) \(\uparrow\) (\(\approx\)) \(\uparrow\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\uparrow\) (\(\approx\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\uparrow\) (\(\uparrow\)) \(\downarrow\) (\(\uparrow\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\downarrow\))
Strain rate (R) Systolic (ES) \(\uparrow\) (\(\approx\)) \(\downarrow\) (\(\approx\)) \(\downarrow\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\approx\))
Diastolic (ED) \(\approx\) (\(\approx\)) \(\uparrow\) (\(\downarrow\)) \(\uparrow\) (\(\downarrow\)) \(\approx\) (\(\approx\)) \(\uparrow\) (\(\downarrow\))
Velocity (L,C,R) Systolic (ES) \(\uparrow\) (\(\approx\)) \(\downarrow\) (\(\approx\)) \(\downarrow\) (\(\downarrow\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\approx\))
Diastolic (ED) \(\approx\) (\(\uparrow\)) \(\uparrow\) (\(\downarrow\)) \(\downarrow\) (\(\approx\)) \(\approx\) (\(\approx\)) \(\downarrow\) (\(\downarrow\))
LA strain (L) ES \(\approx\) \(\downarrow\) \(\downarrow\) \(\approx\) \(\downarrow\)