Table 2 Effect of model changes reflecting different pathological mechanisms (columns) on phenotypic mechanical markers (rows). WT = wall thickness, FA = fractional anisotropy, and Comb. = combination
From: Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study
Metrics | Time period | WT \(\uparrow\) | Passive force \(\uparrow\) | Active force \(\downarrow\) | FA \(\uparrow\) | Comb. |
|---|---|---|---|---|---|---|
Wall thickening | Systolic (ES) | \(\uparrow\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) | \(\downarrow\) (\(\downarrow\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | |
Strain (L) | Systolic (ES) | \(\uparrow\) (\(\uparrow\)) | \(\uparrow\) (\(\uparrow\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | |
Strain (C) | Systolic (ES) | \(\uparrow\) (\(\approx\)) | \(\uparrow\) (\(\uparrow\)) | \(\uparrow\) (\(\uparrow\)) | \(\uparrow\) (\(\approx\)) | \(\uparrow\) (\(\uparrow\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | |
Strain (R) | Systolic (ES) | \(\uparrow\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) | \(\downarrow\) (\(\downarrow\)) | \(\downarrow\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | |
Strain rate (L) | Systolic (ES) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) | |
Strain rate (C) | Systolic (ES) | \(\downarrow\) (\(\approx\)) | \(\uparrow\) (\(\approx\)) | \(\uparrow\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\uparrow\) (\(\approx\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\uparrow\) (\(\uparrow\)) | \(\downarrow\) (\(\uparrow\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) | |
Strain rate (R) | Systolic (ES) | \(\uparrow\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) |
Diastolic (ED) | \(\approx\) (\(\approx\)) | \(\uparrow\) (\(\downarrow\)) | \(\uparrow\) (\(\downarrow\)) | \(\approx\) (\(\approx\)) | \(\uparrow\) (\(\downarrow\)) | |
Velocity (L,C,R) | Systolic (ES) | \(\uparrow\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\approx\)) |
Diastolic (ED) | \(\approx\) (\(\uparrow\)) | \(\uparrow\) (\(\downarrow\)) | \(\downarrow\) (\(\approx\)) | \(\approx\) (\(\approx\)) | \(\downarrow\) (\(\downarrow\)) | |
LA strain (L) | ES | \(\approx\) | \(\downarrow\) | \(\downarrow\) | \(\approx\) | \(\downarrow\) |