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Table 1 Overview of the cases of the sensitivity analysis and the corresponding variations of model components

From: Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study

Case Geom. (mean WT ± std) Passive force (C) Active force (\(T^{\text {V}}_{\text {max}}\)/\(T^{\text {A}}_{\text {max}}\)) FO
Case 1 Control (\(10\,\pm \,2.3\) mm) Control (309 Pa) Control (100/35 kPa) Control
Case 2 Control (\(10\,\pm \,2.3\) mm) Stiffened (1545 Pa) Control (100/35 kPa) Control
Case 3 Control (\(10\,\pm \,2.3\) mm) Control (309 Pa) Decreased (60/21 kPa) Control
Case 4 Control (\(10\,\pm \,2.3\) mm) Stiffened (1545 Pa) Decreased (60/21 kPa) Control
Case 5 HCM 1 (15 ± 3.3 mm) Control (309 Pa) Control (100/35 kPa) Control
Case 6 HCM 2 (17 ± 4.1 mm) Control (309 Pa) Control (100/35 kPa) Control
Case 7 HCM 2 (17 ± 4.1 mm) Stiffened (1545 Pa) Control (100/35 kPa) Control
Case 8 HCM 2 (17 ± 4.1 mm) Control (309 Pa) Decreased (60/21 kPa) Control
Case 9 HCM 2 (17 ± 4.1 mm) Stiffened (1545 Pa Decreased (60/21 kPa) Control
Case 10 HCM 2 (17 ± 4.1 mm) Control (309 Pa) Control (100/35 kPa) Disarray
Case 11 HCM 2 (17 ± 4.1 mm) Stiffened (1545 Pa) Control (100/35 kPa) Disarray
Case 12 HCM 2 (17 ± 4.1 mm) Control (309 Pa) Decreased (60/21 kPa) Disarray
Case 13 HCM 2 (17 ± 4.1 mm) Stiffened (1545 Pa) Decreased (60/21 kPa) Disarray
  1. Geom = geometry, C is the global stiffness in the myocardial tissue, \(T^{\text {V}}_{\text {max}}\) is maximal active force in both ventricles, \(T^{\text {A}}_{\text {max}}\) is maximal active force in both atria, and FO = fiber orientation