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Table 1 The six nebulizer types used in the study, delivered doses and percentage delivered dosage for loading dose (DD/LD) and emitted dose (DD/ED) values obtained in Experiment 1 (mean ± SD) *\(p < 0.05\) versus the JN-PARIr; JN-PARIr: PARI BOY SX + LC SPRINT—red nozzle, JN-PARIb: PARI BOY SX + LC SPRINT—blue nozzle, SMN-U150: NE-U150, SMN-U22: NE-U22, VMN-SM1: NE-SM1 NEPLUS, VMN-SM3: NE-SM3

From: In vitro delivery efficiencies of nebulizers for different breathing patterns

Breathing Parameter Jet Static mesh Vibrating mesh
JN-PARIr JN-PARIb SMN-U22 SMN-U150 VMN-SM1 VMN-SM3
ISO 27427:2013 Delivered dose (mg) 0.403 ± 0.010 0.277 ± 0.014* 0.416 ± 0.005 0.420 ± 0.016 0.589 ± 0.012* 0.389 ± 0.011
DD/LD (%) 20.17 ± 0.51 13.83 ± 0.70* 20.78 ± 0.24 21.01 ± 0.80 29.48 ± 0.60* 19.45 ± 0.56
DD/ED (%) 27.61 ± 0.70 20.18 ± 1.02* 21.85 ± 0.25* 26.62 ± 1.02 29.61 ± 0.61* 19.60 ± 0.57*
Normal adult Delivered dose (mg) 0.251 ± 0.007 0.163 ± 0.010* 0.305 ± 0.024* 0.281 ± 0.012 0.419 ± 0.018* 0.244 ± 0.004
DD/LD (%) 12.59 ± 0.37 8.13 ± 0.50* 15.25 ± 1.20 14.06 ± 0.61 20.94 ± 0.88* 12.21 ± 0.71
DD/ED (%) 17.24 ± 0.51 11.86 ± 0.72* 16.02 ± 1.27 17.81 ± 0.77 21.03 ± 0.88* 12.30 ± 0.71*
Asthma Delivered dose (mg) 0.186 ± 0.022 0.106 ± 0.015* 0.106 ± 0.015* 0.199 ± 0.013 0.353 ± 0.011* 0.157 ± 0.015
DD/LD (%) 9.28 ± 1.17 5.34 ± 0.76* 5.34 ± 0.76* 9.97 ± 0.68 17.65 ± 0.54* 7.83 ± 0.74
DD/ED (%) 12.70 ± 1.51 7.79 ± 1.11* 7.79 ± 1.11* 12.62 ± 0.87 17.73 ± 0.54* 7.89 ± 0.75*
COPD Delivered dose (mg) 0.144 ± 0.010 0.097 ± 0.002* 0.097 ± 0.002* 0.170 ± 0.025 0.259 ± 0.002* 0.137 ± 0.011
DD/LD (%) 7.22 ± 0.49 4.85 ± 0.11* 4.85 ± 0.11* 8.51 ± 1.26 12.96 ± 0.11* 6.85 ± 0.56
DD/ED (%) 9.88 ± 0.66 7.07 ± 0.15* 7.07 ± 0.15* 10.79 ± 1.59 13.02 ± 0.11* 6.90 ± 0.56*