Fig. 1

Inhibition of miR-153 ameliorated cardiac function in myocardial ischemia–reperfusion rat. Adult Sprague–Dawley rats were received the intramyocardial injection of saline (sham and I/R group), adenovirus-expressing miR-nonsense control (miR-NC), or anti-miR-153. Then, these rats were subjected to I/R treatment. LVEDD (a), LVESD (b), LVEF (c), LVFS (d), LVSP (e), and LVEDP (f) levels in the four groups were measured. g, h The influences of miR-153 on LV ± dp/dtmax were measured. n = 8 for each group. Experiments have repeated for three times independently. Data are presented as mean ± SD. *p < 0.05, **p < 0.01 compared to sham group. ^#p < 0.05 and ^##p < 0.01 compared to IR group. LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic diameter, LVEF left ventricular ejection fraction, LVFS left ventricular fraction shortening, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure