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Fig. 2 | BioMedical Engineering OnLine

Fig. 2

From: Organ-on-a-chip: recent breakthroughs and future prospects

Fig. 2

(reprinted with permission from [64] Copyright © 2010, American Association for the Advancement of Science)

Lung-on-a-chip system. a An alveolar–capillary barrier was produced on porous flexible PDMS membranes coated with ECM using spaced PDMS microchannels. The device reproduced respiratory motion through a vacuum leading to mechanical stretching and the formation of an alveolar–capillary barrier; b following inhalation, the diaphragm contracts, reducing pleura pressure. The alveolar–capillary interface became stretched due to alveoli tension; c device development: a porous membrane between the upper and lower channels bound irreversibly following plasma exposure; d PDMS moved through the side of the channels and then was removed following vacuum pressure. e Actual images of the device

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