Fig. 10
Adapted with permission from Ref. [126]. Copyright 2018 Springer Nature Publishing
Schematic diagram of multispectral-LSS system. a The multispectral-LSS fiber probe performs rapid automated rotational/longitudinal scanning of the entire Barrett’s esophagus segment during the clinical procedure. b–d Pseudo-color maps produced from LSS data are overlaid with circles indicating biopsy sites and confirmed pathology. The vertical direction indicates the angle of rotation from the start of each rotary scan; the horizontal direction shows the distance from upper incisors. Green map areas of various shades represent epithelium unlikely for HGD, and red and pink map areas represent areas suspicious for HGD, as determined by LSS. Red and green circles indicate biopsy sites of HGD and non-dysplastic Barrett’s esophagus, respectively, as determined by pathology. Typical maps and biopsies for subjects with b no areas suspicious for HGD, c focal HGD suspicious areas, and d significant HGD suspicious regions, respectively.