Table 3 Top 10 of the most discriminative ROI features and correlative features that were selected using the proposed classification framework

Grade 1 and Grade 2

1

Orbitofrontal cortex (superior)_R

25

Inferior frontal gyrus (opercular)_L-inferior frontal gyrus (opercular)_R

5

2

Superior temporal gyrus_R

25

Inferior frontal gyrus (opercular)_L-insula_R

5

3

Middle temporal gyrus_L

23

Inferior frontal gyrus (opercular)_L-anterior cingulate gyrus_R

5

4

Angular gyrus_L

22

Inferior frontal gyrus (opercular)_L-precuneus_R

5

5

Precuneus_R

22

Superior parietal gyrus_L-precuneus_R

5

6

Superior temporal gyrus_L

22

Inferior frontal gyrus (opercular)_L-caudate_L

5

7

Supramarginal gyrus_L

21

Posterior cingulate gyrus_L-pallidum_R

5

8

Angular gyrus_R

21

Orbitofrontal cortex (superior)_L-inferior frontal gyrus (opercular)_L

4

9

Temporal pole (superior)_R

21

Inferior frontal gyrus (opercular)_L-inferior frontal gyrus (triangular)_L

4

10

Inferior frontal gyrus (opercular)_R

20

Inferior frontal gyrus (opercular)_L-anterior cingulate gyrus_L

4

Grade 1 and Grade 3

1

Rolandic operculum_R

25

Superior frontal gyrus (medial) _R-posterior cingulate gyrus_L

5

2

Rectus gyrus_R

24

Olfactory_L-parahippocampal gyrus_R

5

3

Insula_R

24

Rolandic operculum_L-cuneus_L

5

4

Superior-temporal gyrus_L

24

Olfactory_L-superior occipital gyrus _L

5

5

Superior frontal gyrus (dorsal) _L

23

Superior frontal gyrus (medial) _L-superior occipital gyrus _L

5

6

Orbitofrontal cortex (superior) _L

23

Cuneus_L-fusiform gyrus_R

5

7

Superior temporal gyrus _R

23

ParaHippocampal gyrus_R-superior parietal gyrus _R

5

8

Inferior temporal gyrus _L

23

Posterior cingulate gyrus_L-supramarginal gyrus _L

5

9

Orbitofrontal cortex (medial) _R

22

Superior occipital gyrus_L-supramarginal gyrus _L

5

10

Middle temporal gyrus _R

21

Superior occipital gyrus_L-precuneus_R

5

Grade 1 and Grade 4

1

Superior temporal gyrus_L

25

Inferior frontal gyrus (opercular) _R-middle cingulate gyrus _R

5

2

Superior frontal gyrus (dorsal) _L

23

Orbitofrontal cortex (medial) _R-posterior cingulate gyrus_L

5

3

Orbitofrontal cortex (superior) _R

23

Middle cingulate gyrus_R-middle occipital gyrus _L

5

4

Inferior frontal gyrus (triangular) _L

22

Posterior cingulate gyrus_L-angular gyrus_L

5

5

Supplementary motor area_L

22

Middle cingulate gyrus_L-paracentral lobule _R

5

6

Supplementary motor area_R

22

Inferior frontal gyrus (opercular) _R-putamen_L

5

7

Rectus gyrus_R

22

Superior frontal gyrus (medial) _R-putamen_L

5

8

Superior temporal gyrus_R

22

Orbitofrontal cortex (medial) _L-putamen_L

5

9

Middle frontal gyrus_L

21

Hippocampus_L-putamen_L

5

10

Orbitofrontal cortex (inferior) _L

21

ParaHippocampal gyrus_L-putamen_L

5