Fig. 6

Neuronal responses to a time-varying stimulation paradigm. a A-HFS with a ramped-intensity and 400 Hz frequency suppressed the initial APS events, but large APS reappeared when the pulse frequency dropped directly from 400 to 100 Hz. Top: schematic diagrams of the changes of pulse frequency and intensity; middle: recording signal with stimulation artifacts removed; bottom: expanded plots of APS waveforms. b Scatter diagrams of the normalized amplitudes of APS evoked by each pulse during the 100-s stimulation