Numerical study of gene electrotransfer efficiency based on electroporation volume and electrophoretic movement of plasmid DNA

Table 1 Definition of numerical model: geometry of the skin together with electrical and thermal properties of the skin tissue, plasmid volume and electrodes

	Thickness (μm)	Electrical conductivity (S/m)	Density (kg/m³)	Thermal conductivity (W/m K)	Heat capacity (J/kg K)
Local transport region (LTR)	5	0.1	1400	0.2	3600
Stratum corneum	5	0.0001	1400	0.2	3600
Epidermis	15	0.2–0.8^a	1200	0.24	3600
Dermis	200	0.2–0.8^a	1200	0.45	3300
Adipose tissue	150	0.05–0.2^a	900	0.19	2400
Muscle tissue	90	0.5	1040	0.5	3350
Subcutaneous tissue	2000	0.05	900	0.19	2400
Plasmid volume	–	1.4	1000	0.6	3600
Electrodes	–	1.35 × 106	7810	16.9	477

ISSN: 1475-925X