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Fig. 1 | BioMedical Engineering OnLine

Fig. 1

From: The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

Fig. 1

Schematic diagram of electromechanical simulation. The left side of the diagram is a ventricular model of electrophysiological simulation. The electrical components represent the currents, pumps, and ion exchangers from the Ten Tusscher ion model, which emulates the cell membrane for ion transport and the sarcoplasmic reticulum within cardiac cells. “I” represents the ion currents, and “E” is equilibrium potentials of each ion. (For more details, see the text.) The mechanical components on the right side are myofilament models proposed by Rice et al. [14]. N xb and P xb are nonpermissive and permissive confirmation of regulatory proteins, respectively. K np and K pn are transition rates, K np (TCa Tot )7.5 is the forward rate of the nonpermissive-to-permissive transition, and, working in the opposite direction, and K pn (TCa Tot )−7.5 is the backward rate of the permissive-to-nonpermissive transition. g xbT is the ATP-consuming detachment transition rate, h fT and h bT are the forward transition rate and the backward transition rate, respectively; f aapT is the crossbridge attachment rate of transition to the first strongly bound state XB PreR , and g aapT is the reverse rate. XB PreR represents prerotated states of the myosin head in relation to binding. XB PostR denotes a strongly bound myosin head

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