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Fig. 1 | BioMedical Engineering OnLine

Fig. 1

From: The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study

Fig. 1

Schematic diagram of the electrical and mechanical finite-element ventricular model coupled with calcium transient, circulatory system, and continuous flow LVAD models. Electrical model: fast inward Na+ current (INa), background Na+ current (INa, b), L-type inward Ca2+ current (ICa, L), background Ca2+ current (ICa, b), rapid delayed rectifier K+ current (IKr), slow delayed rectifier K+ current (IKs), inward rectifier K1 current (IK1), Na+–Ca2+ exchange current (INa, Ca), sarcoplasmic Ca2+ pump current (Ip, Ca), Na+–K+ exchange current (INa, K), transient outward K+ current (Ito), K+ pump current (Ip, K), Ca2+ release current from the JSR (Irel), Ca2+ leak current from the JSR (Irel), and Ca2+ uptake current into the NSR (Iup). EAT electrical activation time. Mechanical element: PRV RV pressure, VRV RV volume, PLV LV pressure, VLV LV volume, RPA pulmonary artery resistance, CPA pulmonary artery compliance, RPV pulmonary vein resistance, CPV pulmonary vein compliance, RMI mitral valve resistance, CLA left atrium compliance, RAO aortic valve resistance, RSA systemic artery resistance, CSA systemic artery compliance, RSV systemic vein resistance, CSV systemic vein compliance, RTR tricuspid valve resistance, CRA right atrium compliance, RPU pulmonary valve resistance. The section under the mechanical model, which receives the calcium as input, reveals the calcium and cross-bridge activation status [8]. Nxb nonpermissive confirmations of the regulatory proteins, Pxb permissive confirmations of the regulatory proteins, XBpreR transition of pre-rotated, which is the binding of myosin head to the actin, XBpostR post-rotated state

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