TY - JOUR AU - Dong, H. AU - Zhang, X. AU - Qian, Y. PY - 2014 DA - 2014// TI - Mast cells and neuroinflammation JO - Med Sci Monit Basic Res. VL - 20 UR - https://doi.org/10.12659/MSMBR.893093 DO - 10.12659/MSMBR.893093 ID - Dong2014 ER - TY - JOUR AU - DiSabato, D. J. AU - Quan, N. AU - Godbout, J. P. PY - 2016 DA - 2016// TI - Neuroinflammation: the devil is in the details JO - J Neurochem VL - 139 UR - https://doi.org/10.1111/jnc.13607 DO - 10.1111/jnc.13607 ID - DiSabato2016 ER - TY - JOUR AU - Huh, Y. AU - Ji, R. R. AU - Chen, G. PY - 2017 DA - 2017// TI - Neuroinflammation, bone marrow stem cells, and chronic pain JO - Front Immunol. VL - 8 UR - https://doi.org/10.3389/fimmu.2017.01014 DO - 10.3389/fimmu.2017.01014 ID - Huh2017 ER - TY - JOUR AU - Ji, R. R. AU - Xu, Z. Z. AU - Gao, Y. J. PY - 2014 DA - 2014// TI - Emerging targets in neuroinflammation-driven chronic pain JO - Nat Rev Drug Discov. VL - 13 UR - https://doi.org/10.1038/nrd4334 DO - 10.1038/nrd4334 ID - Ji2014 ER - TY - JOUR AU - Hirsch, E. C. AU - Vyas, S. AU - Hunot, S. PY - 2012 DA - 2012// TI - Neuroinflammation in Parkinson’s disease JO - Parkinsonism Relat Disord. VL - 18 UR - https://doi.org/10.1016/S1353-8020(11)70065-7 DO - 10.1016/S1353-8020(11)70065-7 ID - Hirsch2012 ER - TY - JOUR AU - Rai, S. AU - Kamat, P. K. AU - Nath, C. AU - Shukla, R. PY - 2014 DA - 2014// TI - Glial activation and synaptic neurotoxicity in Alzheimer’s disease: a focus on neuroinflammation JO - Pharmacologia. VL - 5 UR - https://doi.org/10.5567/pharmacologia.2014.286.297 DO - 10.5567/pharmacologia.2014.286.297 ID - Rai2014 ER - TY - JOUR AU - Grigoriadis, N. AU - Grigoriadis, S. AU - Polyzoidou, E. AU - Milonas, I. AU - Karussis, D. PY - 2006 DA - 2006// TI - Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autoimmune reaction JO - Clin Neurol Neurosurg VL - 108 UR - https://doi.org/10.1016/j.clineuro.2005.11.006 DO - 10.1016/j.clineuro.2005.11.006 ID - Grigoriadis2006 ER - TY - JOUR AU - Ellis, A. AU - Bennett, D. L. H. PY - 2013 DA - 2013// TI - Neuroinflammation and the generation of neuropathic pain JO - Br J Anaesth VL - 111 UR - https://doi.org/10.1093/bja/aet128 DO - 10.1093/bja/aet128 ID - Ellis2013 ER - TY - JOUR AU - Foresti, M. L. AU - Arisi, G. M. AU - Shapiro, L. A. PY - 2011 DA - 2011// TI - Role of glia in epilepsy-associated neuropathology, neuroinflammation and neurogenesis JO - Brain Res Rev VL - 66 UR - https://doi.org/10.1016/j.brainresrev.2010.09.002 DO - 10.1016/j.brainresrev.2010.09.002 ID - Foresti2011 ER - TY - JOUR AU - Eggert, D. AU - Dash, P. K. AU - Gorantla, S. AU - Dou, H. AU - Schifitto, G. AU - Maggirwar, S. B. PY - 2010 DA - 2010// TI - Neuroprotective activities of CEP-1347 in models of neuroAIDS JO - J Immunol. VL - 184 UR - https://doi.org/10.4049/jimmunol.0902962 DO - 10.4049/jimmunol.0902962 ID - Eggert2010 ER - TY - JOUR AU - Moller, T. PY - 2010 DA - 2010// TI - Neuroinflammation in Huntington’s disease JO - J Neural Transm. VL - 117 UR - https://doi.org/10.1007/s00702-010-0430-7 DO - 10.1007/s00702-010-0430-7 ID - Moller2010 ER - TY - JOUR AU - Pedata, F. AU - Pugliese, A. M. AU - Coppi, E. AU - Dettori, I. AU - Maraula, G. AU - Cellai, L. PY - 2014 DA - 2014// TI - Adenosine A2A receptors modulate acute injury and neuroinflammation in brain ischemia JO - Mediators Inflamm VL - 2014 UR - https://doi.org/10.1155/2014/805198 DO - 10.1155/2014/805198 ID - Pedata2014 ER - TY - JOUR AU - Bharate, S. B. AU - Sawant, S. D. AU - Singh, P. P. AU - Vishwakarma, R. A. PY - 2013 DA - 2013// TI - Kinase inhibitors of marine origin JO - Chem Rev VL - 113 UR - https://doi.org/10.1021/cr300410v DO - 10.1021/cr300410v ID - Bharate2013 ER - TY - JOUR AU - Wang, G. AU - Pan, J. AU - Chen, S. D. PY - 2012 DA - 2012// TI - Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson’s disease JO - Prog Neurobiol VL - 98 UR - https://doi.org/10.1016/j.pneurobio.2012.06.003 DO - 10.1016/j.pneurobio.2012.06.003 ID - Wang2012 ER - TY - JOUR AU - Tell, V. AU - Hilgeroth, A. PY - 2013 DA - 2013// TI - Recent developments of protein kinase inhibitors as potential AD therapeutics JO - Front Cell Neurosci. VL - 7 UR - https://doi.org/10.3389/fncel.2013.00189 DO - 10.3389/fncel.2013.00189 ID - Tell2013 ER - TY - JOUR AU - Crown, E. D. PY - 2012 DA - 2012// TI - The role of mitogen activated protein kinase signaling in microglia and neurons in the initiation and maintenance of chronic pain JO - Exp Neurol VL - 234 UR - https://doi.org/10.1016/j.expneurol.2011.10.019 DO - 10.1016/j.expneurol.2011.10.019 ID - Crown2012 ER - TY - JOUR AU - Chen, N. F. AU - Chen, W. F. AU - Sung, C. S. AU - Lu, C. H. AU - Chen, C. L. AU - Hung, H. C. PY - 2016 DA - 2016// TI - Contributions of p38 and ERK to the antinociceptive effects of TGF-beta1 in chronic constriction injury-induced neuropathic rats JO - J Headache Pain. VL - 17 UR - https://doi.org/10.1186/s10194-016-0665-2 DO - 10.1186/s10194-016-0665-2 ID - Chen2016 ER - TY - JOUR AU - Liu, Y. AU - Holdbrooks, A. T. AU - Sarno, P. AU - Rowse, A. L. AU - Yanagisawa, L. L. AU - McFarland, B. C. PY - 2014 DA - 2014// TI - Therapeutic efficacy of suppressing the JAK/STAT pathway in multiple models of experimental autoimmune encephalomyelitis JO - J Immunol. VL - 192 UR - https://doi.org/10.4049/jimmunol.1301513 DO - 10.4049/jimmunol.1301513 ID - Liu2014 ER - TY - JOUR AU - Mirshafiey, A. AU - Ghalamfarsa, G. AU - Asghari, B. AU - Azizi, G. PY - 2014 DA - 2014// TI - Receptor tyrosine kinase and tyrosine kinase inhibitors: new hope for success in multiple sclerosis therapy JO - Innov Clin Neurosci. VL - 11 ID - Mirshafiey2014 ER - TY - JOUR AU - Kamei, J. AU - Mizoguchi, H. AU - Narita, M. AU - Tseng, L. F. PY - 2001 DA - 2001// TI - Therapeutic potential of PKC inhibitors in painful diabetic neuropathy JO - Expert Opin Investig Drugs VL - 10 UR - https://doi.org/10.1517/13543784.10.9.1653 DO - 10.1517/13543784.10.9.1653 ID - Kamei2001 ER - TY - JOUR AU - Liu, G. AU - Gu, B. AU - He, X. P. AU - Joshi, R. B. AU - Wackerle, H. D. AU - Rodriguiz, R. M. PY - 2013 DA - 2013// TI - Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy JO - Neuron VL - 79 UR - https://doi.org/10.1016/j.neuron.2013.04.027 DO - 10.1016/j.neuron.2013.04.027 ID - Liu2013 ER - TY - JOUR AU - Coultrap, S. J. AU - Vest, R. S. AU - Ashpole, N. M. AU - Hudmon, A. AU - Bayer, K. U. PY - 2011 DA - 2011// TI - CaMKII in cerebral ischemia JO - Acta Pharmacol Sin VL - 32 UR - https://doi.org/10.1038/aps.2011.68 DO - 10.1038/aps.2011.68 ID - Coultrap2011 ER - TY - JOUR AU - Chico, L. K. AU - Eldik, L. J. AU - Watterson, D. M. PY - 2009 DA - 2009// TI - Targeting protein kinases in central nervous system disorders JO - Nat Rev Drug Discov. VL - 8 UR - https://doi.org/10.1038/nrd2999 DO - 10.1038/nrd2999 ID - Chico2009 ER - TY - JOUR AU - Roskoski, R. PY - 2016 DA - 2016// TI - Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes JO - Pharmacol Res VL - 103 UR - https://doi.org/10.1016/j.phrs.2015.10.021 DO - 10.1016/j.phrs.2015.10.021 ID - Roskoski2016 ER - TY - JOUR AU - Roskoski, R. PY - 2015 DA - 2015// TI - A historical overview of protein kinases and their targeted small molecule inhibitors JO - Pharmacol Res VL - 100 UR - https://doi.org/10.1016/j.phrs.2015.07.010 DO - 10.1016/j.phrs.2015.07.010 ID - Roskoski2015 ER - TY - JOUR AU - Hopkins, A. L. AU - Groom, C. R. PY - 2002 DA - 2002// TI - The druggable genome JO - Nat Rev Drug Discov. VL - 1 UR - https://doi.org/10.1038/nrd892 DO - 10.1038/nrd892 ID - Hopkins2002 ER - TY - JOUR AU - Crusz, S. M. AU - Balkwill, F. R. PY - 2015 DA - 2015// TI - Inflammation and cancer: advances and new agents JO - Nat Rev Clin Oncol. VL - 12 UR - https://doi.org/10.1038/nrclinonc.2015.105 DO - 10.1038/nrclinonc.2015.105 ID - Crusz2015 ER - TY - JOUR AU - Rayburn, E. R. AU - Ezell, S. J. AU - Zhang, R. PY - 2009 DA - 2009// TI - Anti-inflammatory agents for cancer therapy JO - Mol Cell Pharmacol. VL - 1 UR - https://doi.org/10.4255/mcpharmacol.09.05 DO - 10.4255/mcpharmacol.09.05 ID - Rayburn2009 ER - TY - JOUR AU - Whartenby, K. A. AU - Calabresi, P. A. AU - McCadden, E. AU - Nguyen, B. AU - Kardian, D. AU - Wang, T. PY - 2005 DA - 2005// TI - Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease JO - Proc Natl Acad Sci USA VL - 102 UR - https://doi.org/10.1073/pnas.0506088102 DO - 10.1073/pnas.0506088102 ID - Whartenby2005 ER - TY - JOUR AU - Skarica, M. AU - Wang, T. AU - McCadden, E. AU - Kardian, D. AU - Calabresi, P. A. AU - Small, D. PY - 2009 DA - 2009// TI - Signal transduction inhibition of APCs diminishes Th17 and Th1 responses in experimental autoimmune encephalomyelitis JO - J Immunol. VL - 182 UR - https://doi.org/10.4049/jimmunol.0803631 DO - 10.4049/jimmunol.0803631 ID - Skarica2009 ER - TY - JOUR AU - Obeid, M. AU - Rosenberg, E. C. AU - Klein, P. M. AU - Jensen, F. E. PY - 2014 DA - 2014// TI - Lestaurtinib (CEP-701) attenuates “second hit” kainic acid-induced seizures following early life hypoxic seizures JO - Epilepsy Res VL - 108 UR - https://doi.org/10.1016/j.eplepsyres.2014.01.019 DO - 10.1016/j.eplepsyres.2014.01.019 ID - Obeid2014 ER - TY - JOUR AU - Lanz, T. V. AU - Becker, S. AU - Osswald, M. AU - Bittner, S. AU - Schuhmann, M. K. AU - Opitz, C. A. PY - 2013 DA - 2013// TI - Protein kinase Cbeta as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis JO - Proc Natl Acad Sci USA VL - 110 UR - https://doi.org/10.1073/pnas.1302569110 DO - 10.1073/pnas.1302569110 ID - Lanz2013 ER - TY - JOUR AU - Dudek, A. Z. AU - Zwolak, P. AU - Jasinski, P. AU - Terai, K. AU - Gallus, N. J. AU - Ericson, M. E. PY - 2008 DA - 2008// TI - Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis JO - Invest New Drugs VL - 26 UR - https://doi.org/10.1007/s10637-007-9079-y DO - 10.1007/s10637-007-9079-y ID - Dudek2008 ER - TY - JOUR PY - 2007 DA - 2007// TI - Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease JO - Neurology. VL - 69 UR - https://doi.org/10.1212/01.wnl.0000277648.63931.c0 DO - 10.1212/01.wnl.0000277648.63931.c0 ID - ref34 ER - TY - JOUR AU - Saporito, M. S. AU - Brown, E. M. AU - Miller, M. S. AU - Carswell, S. PY - 1999 DA - 1999// TI - CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo JO - J Pharmacol Exp Ther VL - 288 ID - Saporito1999 ER - TY - JOUR AU - Bozyczko-Coyne, D. AU - O’Kane, T. M. AU - Wu, Z. L. AU - Dobrzanski, P. AU - Murthy, S. AU - Vaught, J. L. PY - 2001 DA - 2001// TI - CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis JO - J Neurochem VL - 77 UR - https://doi.org/10.1046/j.1471-4159.2001.00294.x DO - 10.1046/j.1471-4159.2001.00294.x ID - Bozyczko-Coyne2001 ER - TY - JOUR AU - Troy, C. M. AU - Rabacchi, S. A. AU - Xu, Z. AU - Maroney, A. C. AU - Connors, T. J. AU - Shelanski, M. L. PY - 2001 DA - 2001// TI - beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation JO - J Neurochem VL - 77 UR - https://doi.org/10.1046/j.1471-4159.2001.t01-1-00218.x DO - 10.1046/j.1471-4159.2001.t01-1-00218.x ID - Troy2001 ER - TY - JOUR AU - Apostol, B. L. AU - Simmons, D. A. AU - Zuccato, C. AU - Illes, K. AU - Pallos, J. AU - Casale, M. PY - 2008 DA - 2008// TI - CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice JO - Mol Cell Neurosci VL - 39 UR - https://doi.org/10.1016/j.mcn.2008.04.007 DO - 10.1016/j.mcn.2008.04.007 ID - Apostol2008 ER - TY - JOUR AU - Conforti, P. AU - Ramos, C. AU - Apostol, B. L. AU - Simmons, D. A. AU - Nguyen, H. P. AU - Riess, O. PY - 2008 DA - 2008// TI - Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington’s disease: restoration by the neuroprotective compound CEP-1347 JO - Mol Cell Neurosci VL - 39 UR - https://doi.org/10.1016/j.mcn.2008.04.012 DO - 10.1016/j.mcn.2008.04.012 ID - Conforti2008 ER - TY - JOUR AU - Carlsson, Y. AU - Leverin, A. L. AU - Hedtjarn, M. AU - Wang, X. AU - Mallard, C. AU - Hagberg, H. PY - 2009 DA - 2009// TI - Role of mixed lineage kinase inhibition in neonatal hypoxia–ischemia JO - Dev Neurosci VL - 31 UR - https://doi.org/10.1159/000232560 DO - 10.1159/000232560 ID - Carlsson2009 ER - TY - JOUR AU - Wakita, S. AU - Izumi, Y. AU - Nakai, T. AU - Adachi, K. AU - Takada-Takatori, Y. AU - Kume, T. PY - 2014 DA - 2014// TI - Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of rapamycin signaling pathway JO - Neuropharmacology VL - 77 UR - https://doi.org/10.1016/j.neuropharm.2013.09.012 DO - 10.1016/j.neuropharm.2013.09.012 ID - Wakita2014 ER - TY - JOUR AU - Goodman, Y. AU - Mattson, M. P. PY - 1994 DA - 1994// TI - Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury JO - Brain Res VL - 650 UR - https://doi.org/10.1016/0006-8993(94)90223-2 DO - 10.1016/0006-8993(94)90223-2 ID - Goodman1994 ER - TY - JOUR AU - Ahlgren, S. C. AU - Levine, J. D. PY - 1994 DA - 1994// TI - Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat JO - J Neurophysiol VL - 72 UR - https://doi.org/10.1152/jn.1994.72.2.684 DO - 10.1152/jn.1994.72.2.684 ID - Ahlgren1994 ER - TY - JOUR AU - Smith-Swintosky, V. L. AU - Kraemer, P. J. AU - Bruce, A. J. AU - McCants, N. AU - Maki, A. AU - Brown, R. W. PY - 1996 DA - 1996// TI - Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits JO - Exp Neurol VL - 141 UR - https://doi.org/10.1006/exnr.1996.0163 DO - 10.1006/exnr.1996.0163 ID - Smith-Swintosky1996 ER - TY - JOUR AU - Hara, H. AU - Onodera, H. AU - Yoshidomi, M. AU - Matsuda, Y. AU - Kogure, K. PY - 1990 DA - 1990// TI - Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat JO - J Cereb Blood Flow Metab VL - 10 UR - https://doi.org/10.1038/jcbfm.1990.117 DO - 10.1038/jcbfm.1990.117 ID - Hara1990 ER - TY - JOUR AU - Ohno, M. AU - Yamamoto, T. AU - Watanabe, S. PY - 1991 DA - 1991// TI - Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia JO - Eur J Pharmacol VL - 204 UR - https://doi.org/10.1016/0014-2999(91)90844-G DO - 10.1016/0014-2999(91)90844-G ID - Ohno1991 ER - TY - JOUR AU - Sanphui, P. AU - Pramanik, S. K. AU - Chatterjee, N. AU - Moorthi, P. AU - Banerji, B. AU - Biswas, S. C. PY - 2013 DA - 2013// TI - Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer’s disease JO - PLoS ONE VL - 8 UR - https://doi.org/10.1371/journal.pone.0078842 DO - 10.1371/journal.pone.0078842 ID - Sanphui2013 ER - TY - JOUR AU - Shabbir, M. AU - Stuart, R. PY - 2010 DA - 2010// TI - Lestaurtinib, a multitargeted tyrosine kinase inhibitor: from bench to bedside JO - Expert Opin Investig Drugs VL - 19 UR - https://doi.org/10.1517/13543781003598862 DO - 10.1517/13543781003598862 ID - Shabbir2010 ER - TY - JOUR AU - Kase, H. AU - Iwahashi, K. AU - Matsuda, Y. PY - 1986 DA - 1986// TI - K-252a, a potent inhibitor of protein kinase C from microbial origin JO - J Antibiot (Tokyo). VL - 39 UR - https://doi.org/10.7164/antibiotics.39.1059 DO - 10.7164/antibiotics.39.1059 ID - Kase1986 ER - TY - JOUR AU - Kaneko, M. AU - Saito, Y. AU - Saito, H. AU - Matsumoto, T. AU - Matsuda, Y. AU - Vaught, J. L. PY - 1997 DA - 1997// TI - Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives JO - J Med Chem VL - 40 UR - https://doi.org/10.1021/jm970031d DO - 10.1021/jm970031d ID - Kaneko1997 ER - TY - JOUR AU - Levis, M. AU - Ravandi, F. AU - Wang, E. S. AU - Baer, M. R. AU - Perl, A. AU - Coutre, S. PY - 2011 DA - 2011// TI - Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse JO - Blood VL - 117 UR - https://doi.org/10.1182/blood-2010-08-301796 DO - 10.1182/blood-2010-08-301796 ID - Levis2011 ER - TY - JOUR AU - Knapper, S. AU - Hills, R. K. AU - Cavenagh, J. D. AU - Kjeldsen, L. AU - Hunter, A. E. AU - Clark, R. E. PY - 2014 DA - 2014// TI - A randomised comparison of the sequential addition of the FLT3 Inhibitor lestaurtinib (CEP701) to standard first line chemotherapy for FLT3-mutated acute myeloid leukemia: the UK experience JO - Blood. VL - 124 ID - Knapper2014 ER - TY - JOUR AU - Knapper, S. AU - Russell, N. AU - Gilkes, A. AU - Hills, R. K. AU - Gale, R. E. AU - Cavenagh, J. D. PY - 2017 DA - 2017// TI - A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML JO - Blood VL - 129 UR - https://doi.org/10.1182/blood-2016-07-730648 DO - 10.1182/blood-2016-07-730648 ID - Knapper2017 ER - TY - JOUR AU - Vergote, I. PY - 2014 DA - 2014// TI - Novel therapies, including enzastaurin, in the treatment of ovarian cancer JO - Expert Opin Investig Drugs VL - 23 UR - https://doi.org/10.1517/13543784.2014.900542 DO - 10.1517/13543784.2014.900542 ID - Vergote2014 ER - TY - JOUR AU - Sweeney, Z. K. AU - Lewcock, J. W. PY - 2011 DA - 2011// TI - ACS chemical neuroscience spotlight on CEP-1347 JO - ACS Chem Neurosci. VL - 2 UR - https://doi.org/10.1021/cn1000793 DO - 10.1021/cn1000793 ID - Sweeney2011 ER - TY - JOUR AU - Maroney, A. C. AU - Finn, J. P. AU - Connors, T. J. AU - Durkin, J. T. AU - Angeles, T. AU - Gessner, G. PY - 2001 DA - 2001// TI - Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M011601200 DO - 10.1074/jbc.M011601200 ID - Maroney2001 ER - TY - JOUR AU - Falsig, J. AU - Porzgen, P. AU - Lotharius, J. AU - Leist, M. PY - 2004 DA - 2004// TI - Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347 JO - J Immunol. VL - 173 UR - https://doi.org/10.4049/jimmunol.173.4.2762 DO - 10.4049/jimmunol.173.4.2762 ID - Falsig2004 ER - TY - JOUR AU - Park, B. S. AU - Abdel-Azeem, A. Z. AU - Al-Sanea, M. M. AU - Yoo, K. H. AU - Tae, J. S. AU - Lee, S. H. PY - 2013 DA - 2013// TI - Staurosporine analogues from microbial and synthetic sources and their biological activities JO - Curr Med Chem VL - 20 UR - https://doi.org/10.2174/09298673113209990176 DO - 10.2174/09298673113209990176 ID - Park2013 ER - TY - JOUR AU - Schupp, P. AU - Steube, K. AU - Meyer, C. AU - Proksch, P. PY - 2001 DA - 2001// TI - Anti-proliferative effects of new staurosporine derivatives isolated from a marine ascidian and its predatory flatworm JO - Cancer Lett VL - 174 UR - https://doi.org/10.1016/S0304-3835(01)00694-2 DO - 10.1016/S0304-3835(01)00694-2 ID - Schupp2001 ER - TY - JOUR AU - Bharate, S. B. AU - Manda, S. AU - Mupparapu, N. AU - Battini, N. AU - Vishwakarma, R. A. PY - 2012 DA - 2012// TI - Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor JO - Mini Rev Med Chem VL - 12 UR - https://doi.org/10.2174/138955712800626719 DO - 10.2174/138955712800626719 ID - Bharate2012 ER - TY - JOUR AU - Shafiq, M. I. AU - Steinbrecher, T. AU - Schmid, R. PY - 2012 DA - 2012// TI - Fascaplysin as a specific inhibitor for CDK4: insights from molecular modelling JO - PLoS ONE VL - 7 UR - https://doi.org/10.1371/journal.pone.0042612 DO - 10.1371/journal.pone.0042612 ID - Shafiq2012 ER - TY - JOUR AU - Leitch, A. E. AU - Haslett, C. AU - Rossi, A. G. PY - 2009 DA - 2009// TI - Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents JO - Br J Pharmacol VL - 158 UR - https://doi.org/10.1111/j.1476-5381.2009.00402.x DO - 10.1111/j.1476-5381.2009.00402.x ID - Leitch2009 ER - TY - STD TI - Zack DJ, Yang Z, Berlinicke C, Quigley H. Compositions and methods for treatment of neurodegenerative disease. US8993615B2. 2015. ID - ref63 ER - TY - STD TI - Valmier J. FLT3 receptor antagonists for the treatment or the prevention of pain disorders. US9109227B2. 2015. ID - ref64 ER - TY - STD TI - Haggarty SJ, Fass D, Pan J, Ketterman J, Holson E, Petryshen TL, et al. Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders. US9265764B2. 2016. ID - ref65 ER - TY - STD TI - Lewis ME, Kauer JC, Neff N, Roberts-Lewis J, Murakata C, Saito H, et al. Selected protein kinase inhibitors for the treatment of neurological disorders. US5461146A. 1995. ID - ref66 ER - TY - STD TI - Lewis ME, Kauer JC, Neff N, Roberts-Lewis J, Murakata C, Saito H, et al. K-252a derivatives for treatment of neurological disorders. US5621100A. 1997. ID - ref67 ER - TY - JOUR AU - Munoz, L. PY - 2017 DA - 2017// TI - Non-kinase targets of protein kinase inhibitors JO - Nat Rev Drug Discov. VL - 16 UR - https://doi.org/10.1038/nrd.2016.266 DO - 10.1038/nrd.2016.266 ID - Munoz2017 ER - TY - JOUR AU - Liu, Y. PY - 2012 DA - 2012// TI - Renaissance of marine natural product drug discovery and development JO - J Mar Sci Res Dev. VL - 02 UR - https://doi.org/10.4172/2155-9910.1000e106 DO - 10.4172/2155-9910.1000e106 ID - Liu2012 ER - TY - JOUR AU - Montaser, R. AU - Luesch, H. PY - 2011 DA - 2011// TI - Marine natural products: a new wave of drugs? JO - Future Med Chem. VL - 3 UR - https://doi.org/10.4155/fmc.11.118 DO - 10.4155/fmc.11.118 ID - Montaser2011 ER - TY - JOUR AU - Grosso, C. AU - Valentao, P. AU - Ferreres, F. AU - Andrade, P. B. PY - 2014 DA - 2014// TI - Bioactive marine drugs and marine biomaterials for brain diseases JO - Mar Drugs. VL - 12 UR - https://doi.org/10.3390/md12052539 DO - 10.3390/md12052539 ID - Grosso2014 ER - TY - JOUR AU - Burgess, J. G. PY - 2012 DA - 2012// TI - New and emerging analytical techniques for marine biotechnology JO - Curr Opin Biotechnol VL - 23 UR - https://doi.org/10.1016/j.copbio.2011.12.007 DO - 10.1016/j.copbio.2011.12.007 ID - Burgess2012 ER - TY - JOUR AU - Zheng, W. AU - Thorne, N. AU - McKew, J. C. PY - 2013 DA - 2013// TI - Phenotypic screens as a renewed approach for drug discovery JO - Drug Discov Today. VL - 18 UR - https://doi.org/10.1016/j.drudis.2013.07.001 DO - 10.1016/j.drudis.2013.07.001 ID - Zheng2013 ER - TY - JOUR AU - Barbosa, M. AU - Valentao, P. AU - Andrade, P. B. PY - 2014 DA - 2014// TI - Bioactive compounds from macroalgae in the new millennium: implications for neurodegenerative diseases JO - Mar Drugs. VL - 12 UR - https://doi.org/10.3390/md12094934 DO - 10.3390/md12094934 ID - Barbosa2014 ER - TY - JOUR AU - Rask-Andersen, M. AU - Almen, M. S. AU - Schioth, H. B. PY - 2011 DA - 2011// TI - Trends in the exploitation of novel drug targets JO - Nat Rev Drug Discov. VL - 10 UR - https://doi.org/10.1038/nrd3478 DO - 10.1038/nrd3478 ID - Rask-Andersen2011 ER - TY - JOUR AU - Stamm, S. PY - 2002 DA - 2002// TI - Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome JO - Hum Mol Genet VL - 11 UR - https://doi.org/10.1093/hmg/11.20.2409 DO - 10.1093/hmg/11.20.2409 ID - Stamm2002 ER - TY - JOUR AU - Jin, D. Q. AU - Lim, C. S. AU - Sung, J. Y. AU - Choi, H. G. AU - Ha, I. AU - Han, J. S. PY - 2006 DA - 2006// TI - Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells JO - Neurosci Lett VL - 402 UR - https://doi.org/10.1016/j.neulet.2006.03.068 DO - 10.1016/j.neulet.2006.03.068 ID - Jin2006 ER - TY - JOUR AU - Zhou, R. AU - Shi, X. Y. AU - Bi, D. C. AU - Fang, W. S. AU - Wei, G. B. AU - Xu, X. PY - 2015 DA - 2015// TI - Alginate-derived oligosaccharide inhibits neuroinflammation and promotes microglial phagocytosis of beta-amyloid JO - Mar Drugs. VL - 13 UR - https://doi.org/10.3390/md13095828 DO - 10.3390/md13095828 ID - Zhou2015 ER - TY - JOUR AU - Cui, Y. AU - Park, J. Y. AU - Wu, J. AU - Lee, J. H. AU - Yang, Y. S. AU - Kang, M. S. PY - 2015 DA - 2015// TI - Dieckol attenuates microglia-mediated neuronal cell death via ERK, Akt and NADPH oxidase-mediated pathways JO - Korean J Physiol Pharmacol. VL - 19 UR - https://doi.org/10.4196/kjpp.2015.19.3.219 DO - 10.4196/kjpp.2015.19.3.219 ID - Cui2015 ER - TY - JOUR AU - Kim, M. AU - Li, Y. X. AU - Dewapriya, P. AU - Ryu, B. AU - Kim, S. K. PY - 2013 DA - 2013// TI - Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia JO - BMB Rep. VL - 46 UR - https://doi.org/10.5483/BMBRep.2013.46.8.237 DO - 10.5483/BMBRep.2013.46.8.237 ID - Kim2013 ER - TY - JOUR AU - Yu, D. K. AU - Lee, B. AU - Kwon, M. AU - Yoon, N. AU - Shin, T. AU - Kim, N. G. PY - 2015 DA - 2015// TI - Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor kappaB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells JO - Int Immunopharmacol VL - 28 UR - https://doi.org/10.1016/j.intimp.2015.08.028 DO - 10.1016/j.intimp.2015.08.028 ID - Yu2015 ER - TY - JOUR AU - Yoon, C. S. AU - Kim, D. C. AU - Lee, D. S. AU - Kim, K. S. AU - Ko, W. AU - Sohn, J. H. PY - 2014 DA - 2014// TI - Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-kappaB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells JO - Int Immunopharmacol VL - 23 UR - https://doi.org/10.1016/j.intimp.2014.10.006 DO - 10.1016/j.intimp.2014.10.006 ID - Yoon2014 ER - TY - JOUR AU - Cho, K. H. AU - Kim, D. C. AU - Yoon, C. S. AU - Ko, W. M. AU - Lee, S. J. AU - Sohn, J. H. PY - 2016 DA - 2016// TI - Anti-neuroinflammatory effects of citreohybridonol involving TLR4-MyD88-mediated inhibition of NF-small ka, CyrillicB and MAPK signaling pathways in lipopolysaccharide-stimulated BV2 cells JO - Neurochem Int VL - 95 UR - https://doi.org/10.1016/j.neuint.2015.12.010 DO - 10.1016/j.neuint.2015.12.010 ID - Cho2016 ER - TY - JOUR AU - Lillsunde, K. E. AU - Festa, C. AU - Adel, H. AU - Marino, S. AU - Lombardi, V. AU - Tilvi, S. PY - 2014 DA - 2014// TI - Bioactive cembrane derivatives from the Indian Ocean soft coral JO - Sinularia kavarattiensis. Mar Drugs. VL - 12 UR - https://doi.org/10.3390/md12074045 DO - 10.3390/md12074045 ID - Lillsunde2014 ER - TY - JOUR AU - Choi, J. Y. AU - Hwang, C. J. AU - Lee, H. P. AU - Kim, H. S. AU - Han, S. B. AU - Hong, J. T. PY - 2017 DA - 2017// TI - Inhibitory effect of ethanol extract of Nannochloropsis oceanica on lipopolysaccharide-induced neuroinflammation, oxidative stress, amyloidogenesis and memory impairment JO - Oncotarget. VL - 8 ID - Choi2017 ER - TY - JOUR AU - Ebrahimi-Kalan, A. AU - Soleimani Rad, J. AU - Kafami, L. AU - Mohammadnejad, D. AU - Habibi Roudkenar, M. AU - Khaki, A. A. PY - 2014 DA - 2014// TI - MS14 down-regulates Lipocalin2 expression in spinal cord tissue in an animal model of multiple sclerosis in female C57BL/6 JO - Iran Biomed J VL - 18 ID - Ebrahimi-Kalan2014 ER - TY - JOUR AU - Ahmadi, A. AU - Habibi, G. AU - Farrokhnia, M. PY - 2010 DA - 2010// TI - MS14, an Iranian herbal-marine compound for the treatment of multiple sclerosis JO - Chin J Integr Med. VL - 16 UR - https://doi.org/10.1007/s11655-010-0270-1 DO - 10.1007/s11655-010-0270-1 ID - Ahmadi2010 ER - TY - JOUR AU - Chen, W. F. AU - Chakraborty, C. AU - Sung, C. S. AU - Feng, C. W. AU - Jean, Y. H. AU - Lin, Y. Y. PY - 2012 DA - 2012// TI - Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease JO - Naunyn Schmiedebergs Arch Pharmacol. VL - 385 UR - https://doi.org/10.1007/s00210-011-0710-2 DO - 10.1007/s00210-011-0710-2 ID - Chen2012 ER - TY - JOUR AU - Feng, C. W. AU - Hung, H. C. AU - Huang, S. Y. AU - Chen, C. H. AU - Chen, Y. R. AU - Chen, C. Y. PY - 2016 DA - 2016// TI - Neuroprotective effect of the marine-derived compound 11-dehydrosinulariolide through DJ-1-related pathway in in vitro and in vivo models of Parkinson’s disease JO - Mar Drugs. VL - 14 UR - https://doi.org/10.3390/md14100187 DO - 10.3390/md14100187 ID - Feng2016 ER - TY - JOUR AU - Wen, Z. H. AU - Chao, C. H. AU - Wu, M. H. AU - Sheu, J. H. PY - 2010 DA - 2010// TI - A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue JO - Eur J Med Chem VL - 45 UR - https://doi.org/10.1016/j.ejmech.2010.09.067 DO - 10.1016/j.ejmech.2010.09.067 ID - Wen2010 ER - TY - JOUR AU - Jean, Y. H. AU - Chen, W. F. AU - Sung, C. S. AU - Duh, C. Y. AU - Huang, S. Y. AU - Lin, C. S. PY - 2009 DA - 2009// TI - Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats JO - Br J Pharmacol VL - 158 UR - https://doi.org/10.1111/j.1476-5381.2009.00323.x DO - 10.1111/j.1476-5381.2009.00323.x ID - Jean2009 ER - TY - JOUR AU - Lin, Y. C. AU - Huang, S. Y. AU - Jean, Y. H. AU - Chen, W. F. AU - Sung, C. S. AU - Kao, E. S. PY - 2011 DA - 2011// TI - Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats JO - Behav Pharmacol VL - 22 UR - https://doi.org/10.1097/FBP.0b013e32834d0ecb DO - 10.1097/FBP.0b013e32834d0ecb ID - Lin2011 ER - TY - JOUR AU - Chen, N. F. AU - Huang, S. Y. AU - Lu, C. H. AU - Chen, C. L. AU - Feng, C. W. AU - Chen, C. H. PY - 2014 DA - 2014// TI - Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-beta1 in neuropathic rats JO - Mar Drugs. VL - 12 UR - https://doi.org/10.3390/md12073792 DO - 10.3390/md12073792 ID - Chen2014 ER - TY - JOUR AU - Lu, Y. AU - Zhao, L. X. AU - Cao, D. L. AU - Gao, Y. J. PY - 2013 DA - 2013// TI - Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord JO - Neuroscience VL - 241 UR - https://doi.org/10.1016/j.neuroscience.2013.03.003 DO - 10.1016/j.neuroscience.2013.03.003 ID - Lu2013 ER - TY - JOUR AU - Xiao, A. J. AU - Chen, W. AU - Xu, B. AU - Liu, R. AU - Turlova, E. AU - Barszczyk, A. PY - 2015 DA - 2015// TI - Marine compound xyloketal B reduces neonatal hypoxic–ischemic brain injury JO - Mar Drugs. VL - 13 UR - https://doi.org/10.3390/md13010029 DO - 10.3390/md13010029 ID - Xiao2015 ER - TY - JOUR AU - Kim, J. H. AU - Lee, N. S. AU - Jeong, Y. G. AU - Lee, J. H. AU - Kim, E. J. AU - Han, S. Y. PY - 2012 DA - 2012// TI - Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain JO - Anat Cell Biol. VL - 45 UR - https://doi.org/10.5115/acb.2012.45.2.103 DO - 10.5115/acb.2012.45.2.103 ID - Kim2012 ER -